Showing 26–50 of 200 documents
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John W Wilson, Zelalem Temesgen, James T Gaensbauer
…of management updates recently have been published for both drug-susceptible and drug-resistant tuberculosis (TB), TB in children, and contacts of patients with drug-resistant TB. The operationalization and application of these recommendations, which reflect favorable clinical tr…
Swargam S, Kumari I, Kumar A, Pradhan D, Alam A, et al.
… gene variations, INDEL/synonymous/PE-PPE (IDP family), and drug resistance from sample data, or are limited to specific objectives, such as drug resistance. It is understood that drug resistance and lineage-specific issues require an elaborate prioritization of identified varian…
Njoku Oluomachi Leticia, Iyanda Ayobola Abolape
…opper (Cu), iron (Fe), and selenium (Se)—in newly diagnosed drug-sensitive tuberculosis (DSTB) and drug-resistant tuberculosis (DRTB) patients compared to a control group without tuberculosis admitted in selected health facilities in Oyo State, Nigeria. Methodology: Over the cour…
Akheruz Zaman Ahmed, Nandini Bhat, Sneha Guruprasad Kalthur
…tiple organ toxicities induced by different anti-tubercular drug resistant groups like isoniazid resistance, rifampicin resistance, multidrug resistance including drug susceptible anti-tubercular drugs and their time of recovery from the toxicities induced by these drugs. Wistar …
Oriekot Anthony, Senai Goitom Sereke, Felix Bongomin, Samuel Bugeza, Zeridah Muyinda
…e. Radiology has an important role in the diagnosis of both drug-sensitive (DS) and drug-resistant (DR) pulmonary TB (PTB). This study aimed at comparing the chest x-ray (CXR) patterns of microbiologically confirmed cases of DS and DR PTB in Uganda. Methods: We conducted a hospit…
Sohag University
…is of all TB patients and prompt treatment with any form of drug-susceptible or drug resistant TB is fundamental. Identifying the pattern of drug resistance will ensure that the most effective therapy can be selected. The aim of this study is to assess the prevalence and patterns…
Vaidehi Mehta, Ramsha Ansari, Ira Shah
…year-old girl with steroid-resistant nephrotic syndrome and drug-sensitive pulmonary tuberculosis (Xpert MTB/Rif) and preextensively drug-resistant tuberculosis neuro-tuberculosis (Line Probe Assay). Mixed tuberculosis involving drug-susceptible and drug-resistant strains can hin…
Soraya Riefani, Juhairina Juhairina, Mohamad Isa, Erna Kusumawardhani, Haryati Haryati, et al.
… mortality. Based on its classification, TB is divided into drug-sensitive (DS) and drug-resistant (DR). Several risk factors susceptible to TB are malnutrition with low body mass index (BMI), vitamin D deficiency (VDD), and low total lymphocyte count (TLC) related to low immune …
Feng Yang, Hang Yu, Karthik Kantipudi, Alex Rosenthal, Darrell E. Hurt, et al.
… years, great progress has been made in care and control of drug-sensitive TB, whereas drug-resistant TB continues to be a worldwide public health problem that takes a heavy toll on both patients and the health care system. Early detection of drug resistance during a patient's fi…
M Dávid, Idah Orowe, Anthony Karanja, Hillary Kipruto
Background: Drug-resistant tuberculosis (DR-TB) is a form of antimicrobial resistance that is difficult and costly to treat. It is caused by TB bacteria that are resistant to at least one of the first-line existing TB medications, resulting in fewer treatment options and increasi…
Oriekot A, Sereke SG, Bongomin F, Bugeza S, Muyinda Z
…e. Radiology has an important role in the diagnosis of both drug-sensitive (DS) and rifampicin-resistant (RR) pulmonary TB (PTB). This study aimed to compare the chest x-ray (CXR) patterns of microbiologically confirmed DS and RR PTB cases stratified by HIV serostatus in Uganda. …
Tigabu Kasie Ayele, Emile Franc Doungmo Goufo, Stella Mugisha
…In this paper, we developed a mathematical model of TB with drug resistance TB (DR-TB) in the presence of optimal control. We considered the two diseases — drug sensitive TB (DS-TB) and drug resistance TB. They affect the country Ethiopia. The DS-TB can be cured by first-line ant…
Tran Duong Thai, Nut Nithimongkolchai, Benjawan Kaewseekhao, Janejira Samarnjit, Chutipapa Sukkasem, et al.
…infection is a significant public-health concern due to its resistance to multiple antibiotics and associated treatment challenges. There is a pressing need for a rapid and effective method capable of reliably identifying M. abscessus drug resistance. Our study aimed to investiga…
Atefeh Sadeghi Shermeh, Majid Khoshmirsafa, Ali‐Akbar Delbandi, Payam Tabarsi, Esmaeil Mortaz, et al.
…s) were studied. TB patients divided into two groups: 1) 67 drug-sensitive (DS-TB) and 2) 20 drug-resistant (DR-TB) according to drug sensitivity test using polymerase chain reaction (PCR). For the genotyping of two SNPs, the PCR-based method was used and IFN-γ and IL-10 levels w…
Novi Maulina, Zinatul Hayati, Zulkarnain Zulkarnain, Kartini Hasballah, Ika Waraztuty
Background: Tuberculosis (TB) remains one of the top ten causes of mortality worldwide. It is caused by a single infectious agent, Mycobacterium tuberculosis. Indonesia has the second highest cases globally and has a high burden of rifampicin-resistant (RR-TB). Xpert MTB/RIF has …
Lindsay McKenna, Jennifer Furin
…g all cadres engaged in the fight against tuberculosis. New drugs are needed urgently, and for the past 20 years the investigational compound known as PA-824—later named pretomanid—has been a promising therapeutic candidate against tuberculosis.3Stover CK Warrener P VanDevanter D…
Nhat Linh Nguyen, Fuad Mirzayev, Kerri Viney, Medea Gegia, Matteo Zignol
<b>Background:</b> Recent developments in TB treatment have prompted the need for revision of the TB treatment outcome definitions. <b>Aims and objectives:</b> The objectives of the WHO consultation were to determine recent changes in TB treatment affecting treatment outcome defi…
Alexandra V. Solovyeva, Grigory Volchenkov, O. Ponomarenko, Tatiana A. Kuznezova, Tatiana R. Somova, et al.
ABSTRACT Introduction Rates of drug-resistant tuberculosis (TB) are increasing worldwide. TB preventive treatment (TPT) for contacts of active TB patients is essential to halt infection progression and transmission. While newer TPT regimens for drug-sensitive strains are expandin…
Yun YJ, Lee JS, Yoo JC, Cho E, Park D, et al.
…kground Rifampicin (RFP) is one of the principal first-line drugs used in combination chemotherapies against Mycobacterium tuberculosis, and its use has greatly shortened the duration of chemotherapy for the successful treatment of drug-susceptible tuberculosis. Compensatory muta…
Charles Omollo, Vinayak Singh, Elizabeth Kigondu, Antonina Wasuna, Pooja Agarwal, et al.
…ous agent, accounting for almost one-third of antimicrobial resistance (AMR) deaths annually. We aimed to identify synergistic anti-TB drug combinations with the capacity to restore therapeutic efficacy against drug-resistant mutants of the causative agent, Mycobacterium tubercul…
Karki M, Kantipudi K, Yang F, Yu H, Wang YXJ, et al.
Classification of drug-resistant tuberculosis (DR-TB) and drug-sensitive tuberculosis (DS-TB) from chest radiographs remains an open problem. Our previous cross validation performance on publicly available chest X-ray (CXR) data combined with image augmentation, the addition of s…
Carlynn G. Winters, Ram M. Basnet, Paige E Faasuamalie, Shamira J. Shallom, Adrian M. Zelazny, et al.
…asis. Here, we demonstrated the activity of an FDA-approved drug, disulfiram, against drug-susceptible and drug-resistant M. abscessus strains utilizing in vitro and intracellular macrophage assays and a zebrafish embryo infection model.
Omollo C, Singh V, Kigondu E, Wasuna A, Agarwal P, et al.
…ous agent, accounting for almost one-third of antimicrobial resistance (AMR) deaths annually. We aimed to identify synergistic anti-TB drug combinations with the capacity to restore therapeutic efficacy against drug-resistant mutants of the causative agent, Mycobacterium tubercul…
Morounfolu Olugbosi, MD MSc
…t of the following treatment regimens in participants with: Drug Sensitive TB (DS-TB) patients given BPaMZ for 17 Weeks ( or 4 months) vs. Standard HRZE/HR treatment given for 26 weeks (or 6 months) and Drug Resistant TB (DR-TB) patients given BPaMZ for 26 Weeks (or 6 months) Ph…
Xiaoyun Du, Keqing Shi, Hao Zhang, Yingzhi Chong
…B) remains a leading global health threat, with the rise of drug-resistant (DR-TB) strains posing a significant impediment to disease control. An increasingly recognized and complex challenge is heteroresistance, the coexistence of drug-susceptible and drug-resistantsubpopulation…