Disulfiram Is Effective against Drug-Resistant Mycobacterium abscessus in a Zebrafish Embryo Infection Model
Carlynn G. Winters, Ram M. Basnet, Paige E Faasuamalie, Shamira J. Shallom, Adrian M. Zelazny, Shashank Gupta, Kenneth N. Olivier
Antimicrobial Agents and Chemotherapy · 2022-10
Abstract
Mycobacterium abscessus is an emerging nontuberculous mycobacterium (NTM) pathogen infecting susceptible people with cystic fibrosis (CF) and non-CF bronchiectasis. Here, we demonstrated the activity of an FDA-approved drug, disulfiram, against drug-susceptible and drug-resistant M. abscessus strains utilizing in vitro and intracellular macrophage assays and a zebrafish embryo infection model.
MeSH terms
- Mycobacterium abscessus
- Nontuberculous mycobacteria
- Microbiology
- Disulfiram
- Cystic fibrosis
- Drug resistance
- Drug
- Biology
- Pathogen
- Mycobacterium
- Zebrafish
- Virology
- Medicine