Showing 26–50 of 200 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Taylor JW, Curtis N, Denholm J
Background The Bacille Calmette-Guérin (BCG) vaccine is primarily used to prevent tuberculosis (TB) infection and disease in settings with high TB incidence. Objective The aim of this review article is to describe the current uses of BCG vaccination in Australia, including the in…
Ahmad S, Bhattacharya D, Gupta N, Rawat V, Tousif S, et al.
…demic regions are vaccinated with Bacillus Calmette Guerin (BCG), which is the only usable vaccine available. BCG is efficacious against meningeal and disseminated TB in children, but protective responses are relatively short-lived and fail to protect against adult pulmonary TB. …
Helen McShane
…nd highly immunogenic in mycobacterially naïve individuals, BCG vaccinated individuals and M.tb latently infected individuals. We will use the same vaccination regime in this study. Participants will be defined as being infected with M.tb.if they have a positive Elispot response …
Rakshit S, Adiga V, Ahmed A, Parthiban C, Chetan Kumar N, et al.
This proof-of-concept study tested if prior BCG revaccination can qualitatively and quantitively enhance antibody and T-cell responses induced by Oxford/AstraZeneca ChAdOx1nCoV-19 or COVISHIELD™, an efficacious and the most widely distributed vaccine in India. We compared COVISHI…
Zhang Y, Xu D, Nie Q, Wang J, Fang D, et al.
…s of fatal infectious diseases worldwide. The only licensed vaccine, Mycobacterium bovis Bacillus Calmette-Guérin (BCG), has variable efficacy against TB in adults. Insufficiency of immune cell function diminishes the protective effects of the BCG vaccine. It is critical to clari…
Fang D, Wang R, Fan X, Li M, Qian C, et al.
…n lives per year in the world, whereas the only licensed TB vaccine BCG exhibits unsatisfactory efficacy in adults. Taking BCG as a vehicle to express Mtb antigens is a promising way to enhance its efficacy against Mtb infection. In this study, the immune efficacy of recombinatio…
Eskild Petersen, Martin Rao, Giuseppe Ippolito, Gina Gualano, Jeremiah Chakaya, et al.
…uch-needed resources to find, diagnose and treat 40 million adults and children who will be affected by TB by 2022, and to conduct research on new diagnostics, treatments and vaccines required to achieve global TB control (Tiberi et al., 2018Tiberi S. Petersen E. Maeurer M. Ntoum…
Prabowo SA, Zelmer A, Stockdale L, Ojha U, Smith SG, et al.
…d vaccination, in particular with Bacillus Calmette-Guérin (BCG), remain the main strategies to control TB. With the emergence of drug resistance, it has been proposed that a combination of TB vaccination with pharmacological treatment may provide a greater therapeutic value. We …
Helen McShane, Dr
…erially naïve individuals, those previously vaccinated with BCG and latently infected individuals. Additionally, 5 x 10\^7 pfu MVA containing HIV antigens administered twice, 4 weeks apart, in HIV positive individuals, is safe. We will use 5 x 107 pfu MVA85A intradermally in this…
Sweeney E, Dahly D, Seddiq N, Corcoran G, Horgan M, et al.
…e from a single infectious agent. Bacillus Calmette-Guerin (BCG) is the only licensed vaccine for TB, yet its efficacy remains debated with variations in vaccine sub-strains, policies, and practices observed across the world. Three BCG vaccination policies were implemented across…
Ramos L, Obregon-Henao A, Henao-Tamayo M, Bowen R, Izzo A, et al.
Many vaccines against childhood diseases are administered early after birth, but vaccine development studies frequently test efficacy in adult rather than in neonatal animal models. In countries with endemic tuberculosis (TB), Bacillus Calmette-Guerin (BCG) is administered as par…
Hafsa Farooq, Hamna Khan, Nimra Akhtar
…ost TB cases (95%) are found in low-income nations. Neonate BCG immunization is recommended by the WHO in countries with a "high prevalence" of tuberculosis.Objective: To determine the frequency of BCG vaccination in children diagnosed with pulmonary Tuberculosis at a tertiary ca…
Festjens N, Vandewalle K, Houthuys E, Plets E, Vanderschaeghe D, et al.
The Mycobacterium bovis Bacille Calmette Guérin (BCG) vaccine shows variable efficacy in protection against adult tuberculosis (TB). Earlier, we have described a BCG mutant vaccine with a transposon insertion in the gene coding for the secreted acid phosphatase SapM, which led to…
Yun Xu, Xiaochun Wang, Qiangsen Zhong
Bacillus Calmette-Guérin (BCG) is the only vaccine currently used in clinical practice to prevent tuberculosis (TB), however, it remains limited in preventing latent infection, TB reactivation, and providing comprehensive protection. In this study, the pcaA gene, an antigen …
Ari MM, Beig M, Sholeh M, Khoshmirsafa M
…usative agent for this infection. Different antibiotics and vaccines have been discussed as potential treatments and prevention. Currently, there is only one licensed vaccine against TB, Bacillus Calmette-Guérin (BCG). Despite its protective efficacy against TB in children, BCG h…
Socorro Miranda-Hernandez, Harindra D Sathkumara, Guangzu Zhao, Louis Schofield, Andreas Kupz
…er 1 million lives annually. Bacillus Calmette-Guérin (BCG), the only licensed vaccine against TB, provides limited efficacy against pulmonary TB in adults and only partial protection against serious disease in children. Hence, the development of safer and more effective new…
Helen McShane
…ally naïve individuals and those previously vaccinated with BCG. We will use the same vaccination regime in this study. Subjects will be defined as being latently infected if they have a positive elispot response to ESAT6 or CFP10. Subjects will be identified from TB contact clin…
Padmini Salgame, Vaishnavi Kaipilyawar
…or the largely variable protective effect against TB of the vaccine Bacille Calmette-Guerin (BCG) is not understood.In this study, we investigated whether epigenetic mechanisms are involved in the response of immune cells to the BCG vaccine.We isolated peripheral blood mononuclea…
Dockrell HM, Butkeviciute E
The BCG vaccine will, in 2021, have been in use for 100 years. Much remains to be understood, including the reasons for its variable efficacy against pulmonary tuberculosis in adults. This review will discuss what has been learnt about the BCG vaccine in the last two decades, and…
Lidia Del Pozo-Ramos, Andreas Kupz
…ausing over a million deaths annually. The only licensed TB vaccine for human use, Bacille Calmette-Guérin (BCG), a mycobacteria-based live-attenuated vaccine, confers immunity to children but fails to efficiently protect adults from pulmonary TB. Several TB vaccine candidat…
Prabowo SA, Smith SG, Seifert K, Fletcher HA
Understanding factors associated with varying efficacy of Bacillus Calmette-Guérin (BCG) would aid the development of improved vaccines against tuberculosis (TB). In addition, investigation of individual-level factors affecting mycobacterial-specific immune responses could provid…
Clark RA, Weerasuriya CK, Portnoy A, Mukandavire C, Quaife M, et al.
…n tuberculosis cases and 506 thousand deaths in 2021. Novel vaccines effective in adolescents and adults could reduce this burden. M72/AS01 E and BCG-revaccination have recently completed phase IIb trials and estimates of their population-level impact are needed. We estimated the…
Walk J, de Bree LCJ, Graumans W, Stoter R, van Gemert GJ, et al.
Recent evidence suggests that certain vaccines, including Bacillus-Calmette Guérin (BCG), can induce changes in the innate immune system with non-specific memory characteristics, termed 'trained immunity'. Here we present the results of a randomised, controlled phase 1 clinical t…
Lei Q, Fu H, Yao Z, Zhou Z, Wang Y, et al.
Background The Bacillus Calmette-Guérin (BCG) vaccine, currently the sole authorized vaccine against tuberculosis (TB), demonstrates limited effectiveness in safeguarding adolescents and adults from active TB, even when administered as a booster with either BCG itself or heterolo…
Serum Institute of India Pvt. Ltd.
This is a Phase II/III trial with two groups of adults successfully cured of category 1 pulmonary TB receiving either VPM1002 or placebo. Single dose of VPM1002 / placebo will be administered to calculate efficacy of the vaccine against TB recurrence. The study is designed as a …