Showing 1–25 of 46 documents
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Mokhele I, Jinga N, Berhanu R, Dlamini T, Long L, et al.
…cribed the safety of second-line anti-TB medications during pregnancy. We aim to describe TB treatment and pregnancy outcomes among pregnant women receiving second-line anti-tuberculosis treatment for MDR/RR-TB in Johannesburg, South Africa. Methods We conducted a retrospective r…
Jennifer A Hughes, Flynn McMorrow, Kristina M Brooks, Mauricio Pinilla, Lee Fairlie, et al.
…re no published data on clofazimine pharmacokinetics during pregnancy, and safety data are limited. We present data from pregnant and postpartum women receiving clofazimine for treatment of rifampicin-resistant tuberculosis (RR-TB). **METHODS:** IMPAACT P1026s was an observation…
Jones AJ, Mathad JS, Dooley KE, Eke AC
…rcular (anti-TB) agents and antiretroviral therapy (ART) in pregnancy. Recent findings This review discusses the currently available evidence on the use of anti-TB agents in pregnant PLWH on ART. Pharmacokinetic and safety studies of anti-TB agents during pregnancy and postpartum…
Marian Loveday, Jennifer Hughes, Nobuhle Mchunu, Nonhlanhla Yende-Zuma, Kerry Holloway, et al.
…prospective, observational study. Maternal TB treatment and pregnancy outcomes were documented through ongoing record reviews and clinical assessments conducted to describe infant outcomes. Using Poisson regression with robust standard errors, we evaluated factors associated with…
Khoza LB, Mulondo SA, Lebese RT
Background Tuberculosis (TB) during pregnancy could confer a high risk for maternal and infant morbidity. Literature indicates that the global burden of active TB disease among pregnant women is not well researched. Statistics for South Africa from WHO give an estimated incidence…
Hui SYA, Lao TT
…m optimal and services for TB needs to be quickly restored. Pregnancy is a unique opportunity to screen and manage TB, and it is an essential step in TB eradication. Early diagnosis and treatment for active disease can reduce maternal and neonatal morbidities and mortality. The m…
Liu Y, Jing A, Yu H
…ease among women of childbearing age, with the incidence of pregnancy with tuberculosis (PWT) is approximately 5-7%. PWT has a serious impact on pregnant women, fetuses and infants, and is also one of the main causes of maternal and infant mortality. Early detection, early diagno…
Orazulike N, Sharma JB, Sharma S, Umeora OUJ
…gy especially in low-income countries, which may complicate pregnancy. Although pulmonary TB is more common in pregnancy than extra pulmonary TB (EPTB), EPTB is becoming more common especially in those living with human deficiency virus (HIV) co infection or have other comorbidit…
Laniado-Laborín R, Carrera-López K, Hernández-Pérez A
…tation is disputable. Some experts favor the termination of pregnancy, whereas others suggest reducing the dose of teratogenic drugs or even suspending the regimen during pregnancy. There have been no clinical trials on the subject, but case reports and case series show excellent…
Hughes JA, Pinilla M, Brooks KM, Eke AC, Stek A, et al.
…quinolones, but data on long-term exposure during and after pregnancy are limited. We examined the pharmacokinetics and safety of levofloxacin in an observational cohort of pregnant and postpartum women receiving treatment for RR-TB. Methods Participants were enrolled in their se…
Sharon Sawe, Lufina Tsirizani, Richard Court, Kamunkhwala Gausi, Asanda Poswa, et al.
…is (RR-TB). There are limited data describing the effect of pregnancy on the pharmacokinetics of levofloxacin. We aimed to characterize the pharmacokinetics of levofloxacin in adults with RR-TB, including the effect of pregnancy. We pooled data from two studies conducted in adult…
Alene KA, Jegnie A, Adane AA
… to examine the impact of MDR-TB and its medications during pregnancy on maternal and perinatal outcomes. Search strategy PubMed, Scopus and Web of Science databases were searched from earliest to February 2020. Selection criteria Records were screened based on pre-defined select…
Shiu JR, Min A, Kiang TKL
…able data on the use of anti-tuberculosis (TB) drugs during pregnancy, with a focus on treatment outcomes, safety, and pharmacokinetics. This qualitative, narrative review was based on literature searches in Medline, Pubmed, Embase, and Google Scholar (from their inception to 13 …
Stroeken Y, Broekhuijsen K, Leyten E, Hermes W
… tube and endometrial pathology leading to subfertility and pregnancy loss. This case report describes a 34-year-old woman from Ivory Coast who was diagnosed with intrauterine tuberculosis after hysteroscopic evacuation of suspected retained placental tissue following an immature…
Lotia Farrukh I, Lachenal N, Adenov MM, Ahmed S, Algozhin Y, et al.
… normal birth weights. Effective MDR/RR-TB treatment during pregnancy can improve maternal outcomes without harming neonates.
Court R, Gausi K, Mkhize B, Wiesner L, Waitt C, et al.
Aims We aimed to explore the effect of pregnancy on bedaquiline pharmacokinetics (PK) and describe bedaquiline exposure in the breast milk of mothers treated for rifampicin-resistant tuberculosis (TB), where there are no human data available. Methods We performed a longitudinal P…
Sharma TS, Amin S, Sapre S, Golani P, Zala S
…inical, psychosocial, and financial burden on the diseased. Pregnancy in a woman with compromised pulmonary function is a challenge for the treating obstetrician. A multidisciplinary approach involving a respiratory physician, pre-conceptional counseling, and delivery at a tertia…
Esmail A, Sabur NF, Okpechi I, Dheda K
…istant TB in special situations including HIV co-infection, pregnancy, renal disease, liver disease, diabetes, and in the critically ill.
van de Water BJ, Brooks MB, Huang CC, Trevisi L, Lecca L, et al.
Background There is limited research to guide TB treatment specifically in pregnant women and few studies have described the presentation of TB in pregnant women. We aimed to understand TB presentation and treatment outcomes in pregnant women in a low HIV burden setting. We descr…
Alene KA, Murray MB, van de Water BJ, Becerra MC, Atalell KA, et al.
…agement of multidrug-resistant tuberculosis (MDR-TB) during pregnancy is challenging, yet no systematic synthesis of evidence has accurately measured treatment outcomes. Objective To systematically synthesize treatment outcomes and adverse events among pregnant patients with MDR-…
Walt MV, Masuku S, Botha S, Nkwenika T, Keddy KH
…nical practice is limited. The study reviewed treatment and pregnancy outcomes and birth outcomes of their new-born in a cohort of pregnant women with DR-TB from three MDR-TB hospitals during 2010 and 2018. Design/methods Data were extracted from: TB register and patient clinic n…
Marian Loveday, Emma Clarence, Sindisiwe Hlangu, Nalini Singh, Sunitha Chotoo, et al.
…ant tuberculosis (MDR/RR-TB). We report maternal treatment, pregnancy, and infant outcomes to 12 months of age in a cohort of pregnant women treated with these regimens. **METHODS:** We included pregnant women treated for MDR/RR-TB from September 2023 to January 2025 in KwaZulu-…
Alene KA, Adane AA, Jegnie A
… women. However, the impact of MDR-TB and its medication on pregnancy and perinatal outcomes has been poorly understood and inconsistently reported. Therefore, using the available literature, we aim to determine whether MDR-TB and its medications during pregnancy impact maternal …
Cornish EF, Hudson J, Sayers R, Loveday M
…ible for bedaquiline therapy. Methods Contraceptive use and pregnancy rates were audited in all female patients aged 13-50 years initiated on our MDR-TB treatment programme in 2016. We then implemented an intervention consisting of procurement of depot-medroxyprogesterone acetate…
Loveday M, Hlangu S, Furin J
…plicated and potentially deadly disease. In terms of their "pregnancy identity" and "RR-TB patient identity" that emerged as part of their care experiences, four key themes were identified that appeared to have elements that were contradictory to one another (contradictory areas)…