Showing 1–25 of 112 documents
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He Y, Lyon CJ, Nguyen DT, Liu C, Sha W, et al.
Diagnosis of pediatric tuberculosis (TB) is often complicated by its nonspecific symptoms, paucibacillary nature, and the need for invasive specimen collection techniques. However, a recently reported assay that detects Mycobacterium tuberculosis virulence factors in serum can di…
Mohammed Suleiman, Andrés Pérez-López, Ruwa Mohamed, Faheem Mirza, Amina Souli, et al.
Diagnosing tuberculosis (TB) in children is challenging due to the paucibacillary nature of the disease and difficulty in obtaining sputum samples. This 6-year retrospective study compared the diagnostic performance of the GeneXpert MTB/RIF Ultra PCR (GX-MTB/R-U) assay, an improv…
Li L, Mao L, van der Zalm MM, Olivo J, Liu S, et al.
Objectives Pediatric tuberculosis (TB) diagnosis is complicated by challenges in obtaining invasive respiratory specimens that frequently contain few Mycobacterium tuberculosis (Mtb) bacilli. We report the diagnostic performance of an Mtb antigen-derived peptide (MAP-TB) assay an…
Grønningen E, Nanyaro M, Sviland L, Ngadaya E, Muller W, et al.
Pediatric extrapulmonary tuberculosis (EPTB) is a diagnostic challenge. A new immunochemistry based MPT64 antigen detection test has shown improved sensitivity compared to current laboratory tests. The aim of this study was to implement and validate the test performance in a reso…
Mijović H, Al-Nasser Y, Al-Rawahi GN, Roberts AD
Microbiologic confirmation of pediatric extrapulmonary tuberculosis remains challenging, leading to diagnostic delays. In our retrospective case series, real-time molecular testing (Xpert MTB/RIF) on respiratory and extrapulmonary specimens resulted in a more rapid diagnosis of e…
Mete Yesil A, Yalcin E, Ademhan Turhal D, Emiralioglu N, Dogru D, et al.
…c profile, and treatment outcomes, and to draw attention to tuberculosis (TB) in Turkey. Methods . A retrospective, descriptive study was undertaken of 93 children aged 0 to 18 years who were admitted to Hacettepe University Pediatric Pulmonology Department for treatment from Jan…
Pace D, Pellegrino R, Dalpiaz I, Renni M, Galli L, et al.
Introduction The diagnosis of pediatric tuberculosis (TB) is challenging, due to the lower sensitivity of microbiological tests, such as culture and microscopy, compared to their performance in adult cases. Guidelines have introduced molecular tests, including GeneXpert MTB/ RIF …
Gupta N, Kashyap B, Dewan P, Hyanki P, Singh NP
Aim and objectives The paucibacillary nature of pediatric tuberculosis (TB) makes diagnosis difficult. The aim of the study was to correlate the clinical spectrum of pediatric TB with microbiological diagnosis. Materials and methods Specimens from clinically suspected pediatric T…
M K, S S, S M
Tuberculosis (TB) is a preventable and curable disease, but increased mortality and morbidity associated with TB is one of the leading causes of deaths worldwide. MicroRNAs (miRNAs) are small, non-coding RNAs known to regulate the host immune response against TB. We investigated …
Kaba Ö, Kara M, Odacılar CA, Kamer İ, Sütçü M, et al.
Aim Extrapulmonary tuberculosis is observed more frequently and leads to complications with a higher rate in children compared with adults because the risk of lymphohematogen spread is higher. In this study, the clinical, laboratory, and radiologic findings and treatment outcomes…
Kaur H, Guglani V, Singhal L, Randev S, Kumar P, et al.
Background Microbiological diagnosis of pediatric tuberculosis (TB) using conventional microbiological techniques has been challenging due to paucibacillary nature of the disease. Molecular methods using cartridge-based tests like Xpert, have immensely improved diagnosis. A novel…
Dilia Fontalvo-Rivera, Maria Daniels-García, Jesly Doria-Atencia, Karen Tous-Barrios, Liliana Molinares-Núñez, et al.
**UNLABELLED:** The diagnosis of extrapulmonary tuberculosis (EPTB) in children is challenging due to the variable and nonspecific manifestations and the low rate of M. tuberculosis isolations which delayed diagnosis, leading to an increase in cases with unfavorable outcomes. **…
Lo Vecchio A, Scarano SM, Amato C, Spagnuolo MI, Bruzzese E, et al.
The outbreak of COVID-19 resulted in a decrease in tuberculosis notification rates globally. We compared tuberculosis incidence rates and disease severity in children seen in our centre prior and during COVID-19 pandemic.We performed a cohort study enrolling children aged under 1…
James V, Samuel J, Ong GY
Background Tuberculosis of the abdomen is one of the most common extrapulmonary manifestations of tuberculosis. Even in areas where tuberculosis is endemic, intra-abdominal tuberculous can pose a diagnostic and management challenge because of the lack of presence of overt clinica…
Moretó-Planas L, Mahajan R, Fidelle Nyikayo L, Ajack YBP, Tut Chol B, et al.
Background More than half of childhood tuberculosis cases remain undiagnosed yearly. The World Health Organization recommends the Xpert-Ultra assay as a first pediatric diagnosis test, but microbiological confirmation remains low. We aimed to determine the diagnostic performance …
Alshrouf MA, Elifranji ZO, Halayqeh S, Al-Saber M, Karam AM
Introduction Tuberculosis (TB) is one of the most prevalent infectious diseases globally, often presenting with nonspecific symptoms that can obscure diagnosis, especially when it manifests in uncommon sites such as osteoarticular tuberculosis (OA-TB). Case presentation We report…
Meredith B Brooks, Giordano Sosa Soto, Jeffrey I Campbell, Farhana Amanullah, Tapash Roy, et al.
Pediatric extrapulmonary tuberculosis (EPTB) remains under-recognized due to biological, diagnostic, and systemic barriers. This Perspective outlines pragmatic, multilevel strategies-spanning frontline clinics to national systems-to strengthen diagnosis, reporting, and visibility…
Movahedi Z, Mahmoudi S, Banar M, Pourakbari B, Aziz-Ahari A, et al.
Introduction Reductions in global tuberculosis incidence are considered as one of the End TB Strategy goal. The diagnosis of tuberculosis (TB) in children is challenging due to insufficient specimen material and the scarcity of bacilli in specimens. The purpose of this study was …
Diwan Israr Khan, Sana Jameel
**BACKGROUND:** Tuberculosis is a common systemic bacterial infectious disease usually caused by Mycobacterium tuberculosis. In India, there are an estimated 2.1 million cases of tuberculosis, with 16% of them being new extrapulmonary tuberculosis cases. Extrapulmonary tuberculos…
Li G, Cannon K, Sisniega C, Fergie J
Pediatric tuberculous meningitis (TBM) is a severe form of tuberculosis that may present in children. The current diagnostic methods may have a limited impact on initial clinical decision-making. We present three children with tuberculous meningitis who had Mycobacterium tubercul…
Jian Zeng, Haitao Su, Jin Wang, Jiaohong Zhang, Shuihua Lu, et al.
…nvestigate the clinical features and prognostic outcomes of pediatric tuberculosis (TB) in Shenzhen. **METHODS:** This retrospective study collected demographic, clinical, laboratory, and prognostic data from pediatric patients diagnosed with TB between January 2013 and January …
González Saldaña N, Macías Parra M, Xochihua Díaz L, Palavicini Rueda M, Carmona Vargas AJ, et al.
…tic, radiological and therapeutic aspects of osteoarticular tuberculosis (OATB) in patients in a tertiary pediatric hospital, to know if the diagnosis of OATB in pediatrics is a challenge due to its insidious clinical presentation. Methods A retrospective, descriptive study of th…
Hamdar H, Nahle AA, Ataya J, Jawad A, Salame H, et al.
Tuberculosis (TB) is a global public health challenge, contributing significantly to morbidity and mortality worldwide. This research aims to investigate the epidemiology, clinical characteristics, diagnostic methods, and early mortality rate among pediatric patients with pulmona…
Hamdar H, Nahle AA, Ataya J, Jawad A, Salame H, et al.
Background Tuberculosis (TB) is a global public health challenge, contributing significantly to morbidity and mortality worldwide. This research aims to investigate the epidemiology, clinical characteristics, diagnostic methods, and early mortality rate among pediatric patients w…
Consonni F, Chiti N, Ricci S, Venturini E, Canessa C, et al.
Immune response to tuberculosis (TB) has been extensively studied in the past decades and classically involves cellular immunity. However, evidence suggests that humoral immunity may play a relevant role. Past studies regarding serum immunoglobulin (Ig) levels in TB are dated and…