Showing 1–25 of 200 documents
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Wang T, Zhou C, Shang L, Zhou X
… positivity. However, there have been few reports of TB and drug resistance in this area. Methods We collected the demographic and clinical data of inpatients with sputum smear positive TB between 2015 and 2021 in an infectious disease hospital in the Liangshan Yi Autonomous Pref…
Diriba G, Kebede A, Tola HH, Alemu A, Yenew B, et al.
…sts allow rapid detection of Mycobacterium tuberculosis and drug resistance in a few days. Identifying the mutations in genes associated with drug resistance may contribute to the development of appropriate interventions to improve tuberculosis control. So far, there is little in…
Karol F Boschung, Patrick H P Wong, Denise Werry, Inna Sekirov, Shannon L Turvey, et al.
We report on 2 patients with drug-resistant tuberculous meningitis diagnosed and treated in a high-resource, low-incidence setting. Both patients were treated with multidrug regimens including bedaquiline, a nitroimidazole, cycloserine, and linezolid. Drug selection was informed …
Chernyaeva E, Rotkevich M, Krasheninnikova K, Lapidus A, Polev DE, et al.
…public health importance. Despite this, problems like early drug resistance, diagnostics and treatment success prediction are still not fully resolved. Here, we analyze the incidence of point mutations widely used for drug resistance detection in laboratory practice and conduct c…
Zhanqiu Mao, Huilie Zheng, Zhenqiong Liu, Zanhua Li, Qilong Zhang
Drug-resistant tuberculosis (DR-TB) poses a critical public health challenge in Jiangxi Province, China, where regional resistance patterns remain understudied. This retrospective study analyzed 9,041 suspected TB patients (2022-2023), identifying 3,104() casesPCR-reverse blot hy…
Paolo Miotto, Francesca Saluzzo, Andrea M Cabibbe, Daniela M Cirillo
…te and timely diagnosis of active tuberculosis (TB) and its drug-resistant forms are essential for effective patient care and global TB disease control. This paper summarizes the latest advances in TB disease diagnostics. We describe mechanisms of drug resistance in, including bo…
Sibandze DB, Magazi BT, Malinga LA, Maningi NE, Shey BA, et al.
…TB). Here, we investigated Mycobacterium tuberculosis (Mtb) drug resistance and transmission patterns in EPTB patients treated in the Tshwane metropolitan area, in South Africa. Methods Consecutive Mtb culture-positive non-pulmonary samples from unique EPTB patients underwent myc…
Ma L, Gao M
…To analyze the clinical characteristics and risk factors of drug resistance of newly-treated chronic obstructive pulmonary disease (COPD) complicated pulmonary tuberculosis (PTB). Methods A total of 489 newly-treated PTB patients admitted to Beijing Geriatric hospital were retros…
Yuejiao Liu, Runrui Wu, Junjun Liu, Jinlong Dai, Dongxu Liu, et al.
…understanding the distinct pathological characteristics and drug resistance patterns of CTB, a subject that has not been extensively explored previously. In this study, we conducted a comparative analysis of 59 CTB samples and 59 pulmonary tuberculosis samples, focusing on their …
Nuwagira E, Yekosani M, Abraham B, Atwine R, Caleb T, et al.
Background Extrapulmonary drug-resistant tuberculosis is extremely rare and is almost always associated with poor treatment outcomes. This is partly due to the difficulty in confirming the diagnosis. Case presentation A 40-year-old HIV-negative male presented with a painless scro…
Kusum Sharma, Megha Sharma, Ritu Shree, Himanshu Joshi, Neeraj Singla, et al.
**PURPOSE:** - The emerging drug resistance in Tuberculous meningitis (TBM) worsens the prognosis and hamper elimination efforts. The need of the hour is a relatively simple, rapid, near point-of-care test that could allow universal drug susceptibility testing, beyond rifampicin …
Pace D, Corvaglia F, Lisi C, Galli L, Chiappini E
…s (EPTB), severe forms of the disease, and the spreading of drug-resistant strains. Describing the characteristics of children with EPTB and those with drug-resistant tuberculosis (DR-TB) and analysing the role of second-line drugs could facilitate the management of these cases. …
Kalawadia D, Gandhi D, Dirkhipa TY, Jaiswal A, Shah D, et al.
… months of Delamanid (DLM) based treatment in children with drug-resistant tuberculosis (DR-TB) and determine factors associated with bacteriological conversion. Methods This is a descriptive retrospective study done in children between the age of 6-17 years with DR-TB who receiv…
Animaw Lingerew, Samuel Addis, Adugnaw Atnafu, Zeru Siyoum, Solomie Jebessa Deribessa
Diagnosing extrapulmonary and drug-resistant tuberculosis in children is challenging. Early recognition and treatment improve outcomes and reduce transmission. In this 9-year-old boy, diagnosis of drug-resistant subphrenic TB required a high index of suspicion, appropriate diagno…
Addo SO, Mensah GI, Mosi L, Abrahams AOD, Addo KK
…es This study sought to determine the genetic diversity and drug resistance profiles of Mycobacterium tuberculosis complex (MTBC) isolates from extrapulmonary tuberculosis (EPTB) patients in Ghana, and their associated immune responses. Methods Spoligotyping was performed on 102 …
Sharma K, Sharma M, Gupta N, Modi T, Joshi H, et al.
…(TruRif) was evaluated for detection of TBLA and rifampicin resistance and compared with GeneXpert Ultra (Xpert Ultra). Design 100 fine-needle aspirated specimens [50 confirmed by culture/smear/cytology, 20 clinically suspected, and 30 controls], processed in the mycobacteriology…
Lohiya S, Tripathy JP, Sagili K, Khanna V, Kumar R, et al.
Extrapulmonary drug-resistant tuberculosis (DR-EPTB) poses a formidable diagnostic and therapeutic challenge.Besides associated with high morbidity, it is a major financial burden for the patient and the health system. In spite of this, it has often been neglected as it does not …
Qiang Liu, Fen Wang, Haoran Wang, Guanglu Jiang, Adong Shen, et al.
…/MeltPro TB for detecting(MTB) and rifampicin and isoniazid resistance in osteoarticular TB. Pus/tissue samples from suspected osteoarticular TB patients were tested by smear, culture, Xpert, and InnowaveDX; drug-susceptibility testing was conducted on MTB isolates. A comprehensi…
Ngwira A, Manda S, Karimuribo ED, Kimera SI
…osis (BTB) and human extrapulmonary tuberculosis (EPTB) and drug-resistant tuberculosis (DRTB) can support integrated disease control and monitoring programmes. We employed the recently developed multivariate disease mapping methods to examine whether the diseases exhibited any s…
Hatolkar SM, Misra RN, Mahato R, Jadhav S
…solates and identify the genomic signatures associated with drug resistance, pathogenesis, and disease transmission. Isolate LJ319 of the Mycobacterium tuberculosis complex (MTC)-Beijing genotype circulating in Maharashtra, India, which was obtained from the cerebrospinal fluid (…
Karami-Zarandi M, Bahador A, Gizaw Feysia S, Kardan-Yamchi J, Hasan-Nejad M, et al.
The potentially pathogenic Non-Tuberculosis Mycobacteria (NTM) are emerging nowadays which result in pulmonary and non-pulmonary infections in human. This group of bacteria consists of at least 200 different species. While the pulmonary disease is the most common form of NTM infe…
Mahendra Kumar, Ramraju Ambati, Prachi J Urade, Anil H Lotke, Musti Venkata Krishnasastry
**BACKGROUND:** Extrapulmonary tuberculosis (EPTB) constitutes 15%-20% of the entire tuberculosis (TB) cases worldwide. However, the lack of proper diagnostic methods, the absence of a reliable model system, and limited knowledge of its pathogenesis impair therapeutic efficacy an…
Manal Arshad Malik, Aleena Kamran, Dua Ahsan, Aafia Amjad, Sara Moatter, et al.
…outcomes, especially in children, due to delayed diagnosis, drug resistance, and limited diagnostic techniques. **METHODS:** This review provides a comprehensive overview of recent advancements in TBM management and treatment. A systematic search was performed across major datab…
Roof I, Jajou R, Kamst M, Mulder A, de Neeling A, et al.
…clusters are thought to be homogeneous regarding antibiotic resistance. In practice, however, heterogeneous clusters are also identified. This study investigates the prevalence and characteristics of heterogeneous VNTR clusters and assesses whether isolates in these clusters rema…
Venus Marie R Rojas, Michaela Zwyer, Selim Bouaouina, Daniela Brites, Sonia Borrell, et al.
…ly widespread and have been repeatedly associated with multidrug resistance. By comparison, MTBC L1 has received little attention, partially because of its restricted geographical range that mainly includes low- to middle-income countries in South and Southeast Asia, and East Afr…