Showing 1–25 of 200 documents
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Jieying Wang, Jinhui Dong, Zhuolin Chen, Yuni Xu, Wenhua Qiu, et al.
**OBJECTIVE:** Multidrug-resistant tuberculosis (MDR-TB) remains a major public health challenge in China. Hainan, China's largest tropical island, possesses distinct socio-geographical features. However, the drug resistance patterns and molecular epidemiology of MDR-TB in this r…
Ghajavand H, Kargarpour Kamakoli M, Khanipour S, Pourazar Dizaji S, Masoumi M, et al.
…eness, it is essential to gain an in-depth insight into the drug resistance mechanisms of Mycobacterium tuberculosis ( M. tuberculosis ). Methods In this study, we evaluated the contribution of 26 drug efflux pumps plus target gene mutations to the drug resistance levels in multi…
Mujuni D, Kasemire DL, Ibanda I, Kabugo J, Nsawotebba A, et al.
Background Second-line drug resistance (SLD) among tuberculosis (TB) patients is a serious emerging challenge towards global control of the disease. We characterized SLD-resistance conferring-mutations among TB patients with rifampicin and/or isoniazid (RIF and/or INH) drug-resis…
Javed H, Bakuła Z, Pleń M, Hashmi HJ, Tahir Z, et al.
…longside the 6th among countries with the highest burden of drug-resistant TB, including multi-drug resistant (MDR)-TB. Methods for rapid and reliable drug susceptibility testing (DST) are prerequisite for the prompt institution of effective anti-TB treatment. The aim of this stu…
Lan Y, Li Y, Chen L, Zhang J, Zhang H
… TB in 2017. The objectives of this study were to determine drug resistance profiles of Mycobacterium tuberculosis clinical isolates and to analyze the trends in drug-resistant and multidrug-resistant tuberculosis (MDR-TB) from 2008 to 2015 at a major hospital in Guizhou, a high-…
Zhao JL, Liu W, Xie WY, Cao XD, Yuan L
…control of TB are greatly difficult, due to the increase in drug-resistant TB, particularly multidrug-resistant TB. We speculated that there were some differences between drug-sensitive and drug-resistant MTB strains and that mazEF 3,6,9 toxin-antitoxin systems (TASs) were involv…
Chiang SS, Brooks MB, Jenkins HE, Rubenstein D, Seddon JA, et al.
Background Household contacts of patients with drug-resistant tuberculosis (TB) are at high risk for being infected with Mycobacterium tuberculosis and for developing TB disease. To guide regimen composition for the empirical treatment of TB infection and disease in these househo…
Li Z, Liu F, Chen H, Han Y, You Y, et al.
…alence and significant clinical outcomes of pre-extensively drug-resistant plus additional drug-resistant tuberculosis (pre-XDR-plus) in Henan Provincial Chest Hospital between 2017 and 2021. Methods We analysed and summarized the drug sensitivity test (DST) results of clinical M…
Yadav R, Saini A, Mankotia J, Khaneja R, Agarwal P, et al.
Rapid detection of drug resistance in Mycobacterium tuberculosis is important for the successful treatment of tuberculosis. Fluoroquinolone and aminoglycoside resistance detection by molecular methods becomes more complex due to cross resistance among them. Thus, we aimed to dete…
Mphande-Nyasulu FA, Puengpipattrakul P, Praipruksaphan M, Keeree A, Ruanngean K
…erall, 70.4% of cases were male and 29.6% were female. Mono-drug-resistant TB, multi-drug-resistant TB and extensively-drug-resistant TB were observed in 2.72%, 4.1% and 0.68% of cases, respectively. Although not statistically significant, individuals with comorbidities had a 2.1…
Mogashoa T, Melamu P, Derendinger B, Ley SD, Streicher EM, et al.
The emergence and transmission of multidrug resistant (MDR) and extensively drug resistant (XDR) Mycobacterium tuberculosis (M.tb) strains is a threat to global tuberculosis (TB) control. The early detection of drug resistance is critical for patient management. The aim of this s…
Cai X, Xu X, He G, Jiang X, Wu L
… a global public health concern. This study aims to compare drug resistance in drug-resistant tuberculosis (DR-TB) patients with and without DM and analyse the risk factors of multidrug-resistant tuberculosis (MDR-TB). Methods A total of 893 DR-TB patients were admitted to Wenzho…
LaFreniere M, Dam D, Strudwick L, McDermott S
Background Drug-resistant tuberculosis (TB) is a public health issue of global importance that poses a threat to TB control efforts. Canada conducts nationwide surveillance to monitor emerging drug resistance trends and document progress towards reaching the goal of TB eliminatio…
Monir BB, Sultana SS, Tarafder S
…um tuberculosis (MTB) contribute to regional differences in drug resistance. The emergence of pre-extensively drug resistant tuberculosis (Pre-XDR-TB) becomes obstacles to achieve End TB strategy in Bangladesh. This cross-sectional study was conducted to identify the strains of d…
Mehrian P, Farnia P, Jalalvand D, Chamani MR, Bakhtiyari M
Purpose Multi-drug-resistant tuberculosis (MDR-TB) is simultaneously resistant to isoniazid and rifampin. Of course, this germ may also be resistant to other anti-tuberculosis drugs. Patients with extensively drug-resistant tuberculosis (XDR-TB) are also resistant to all types of…
Shah I, Poojari V, Meshram H
…high burden countries for tuberculosis (TB) including multi-drug resistant TB (MDR-TB) and extensively-drug resistant (XDR) TB. Drug-resistant (DR) TB has threatened the TB care and is a major health problem in many countries; treatment of DR TB has been difficult requiring use o…
Pan Y, Yu Y, Yi Y, Dou X, Lu J, et al.
Background Diabetes mellitus (DM) and drug-resistant tuberculosis (DR-TB) are serious global public health problems. This study aimed to explore the differences in drug resistance between DR-TB patients with and without DM. Risk factors for developing multidrug-resistant tubercul…
Bainomugisa A, Lavu E, Hiashiri S, Majumdar S, Honjepari A, et al.
An outbreak of multi-drug resistant (MDR) tuberculosis (TB) has been reported on Daru Island, Papua New Guinea. Mycobacterium tuberculosis strains driving this outbreak and the temporal accrual of drug resistance mutations have not been described. Whole genome sequencing of 100 o…
Alarcon-Braga EA, Salazar-Valdivia FE, Estrada-Grossmann JM, Mendez-Guerra C, Pacheco-Barrios N, et al.
Background The growing threat from pre-extensively drug-resistant tuberculosis (pre-XDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) poses a major public health concern in Latin America and the Caribbean (LAC). Therefore, this study aimed to summarize the available ev…
Li Q, Gao H, Zhang Z, Tian Y, Liu T, et al.
The emergence of drug-resistant tuberculosis (TB) is involved in ineffective treatment of TB, especially multidrug resistant/extensively resistant TB (MDR/XDR-TB), leading to acquired resistance and transmission of drug-resistant strains. Second-line drugs (SLD), including both f…
Ketema DB, Alene M, Assemie MA, Yismaw L, Merid MW
Background The emergency of drug resistant tuberculosis is a major public health concern worldwide including Ethiopia. However, little is known about risk factors of mortality among drug resistant tuberculosis patients in the study site. Thus, this study was aimed to estimate the…
Ogwang MO, Imbuga M, Ngugi C, Mutharia L, Magoma G, et al.
Introduction Globally anti-tuberculosis drug resistance is one of the major challenges affecting control and prevention of tuberculosis. Kenya is ranked among 30 high burden TB countries globally. However, there is scanty information on second line antituberculosis drug resistanc…
Bhosale S, Prabhakar A, Srivastava S, Raj A, Purohit S, et al.
…of cases among extra pulmonary osteoarticular tuberculosis. Resistance to drugs in spinal tuberculosis patients is on a rise and there is inadequate literature concentrating on the precise pattern of resistance in Indian subcontinent which harbors 24% of global prevalence. The ai…
Anderson K, Pietersen E, Shepherd BE, Bian A, Dheda K, et al.
…een HIV-positive and HIV-negative South African adults with drug-resistant tuberculosis (DR-TB) and high incidence of acquired second-line drug resistance. Methods We performed a retrospective review of DR-TB patients with serial second-line TB drug susceptibility tests (2008-201…
Rajeev Ranjan, Venkata Siva Reddy Devireddy
Drug resistant tuberculosis is a major public health concern, since the causative agent Mycobacterium tuberculosis is resistant to the most effective drugs against tuberculosis treatment ie., rifampicin and isoniazid. Globally, it accounts 4.6 percent of the patients with tubercu…