Showing 1–25 of 89 documents
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Teljeur C, Moran PS, Harrington P, Butler K, Corcoran B, et al.
Background In Western Europe, currently only Ireland and Portugal continue to provide universal neonatal bacillus Calmette-Guérin (BCG) vaccination programs, despite not being considered as high tuberculosis (TB) incidence countries. Other European countries only vaccinate infant…
Martinez L, Cords O, Liu Q, Acuna-Villaorduna C, Bonnet M, et al.
Background BCG vaccines are given to more than 100 million children every year, but there is considerable debate regarding the effectiveness of BCG vaccination in preventing tuberculosis and death, particularly among older children and adults. We therefore aimed to investigate th…
Nieuwenhuizen NE, Zyla J, Zedler U, Bandermann S, Abu Abed U, et al.
BCG - the only available vaccine against tuberculosis (TB) - was first given to babies 100 years ago in 1921. While it is effective against TB meningitis and disseminated TB, its efficacy against pulmonary TB is variable, notably in adults and adolescents. TB remains one of the w…
Anna Starshinova, Igor Kudryavtsev, Artem Rubinstein, Irina Dovgalyuk, Anastasia Kulpina, et al.
Tuberculosis (TB) remains a fatal disease primarily transmitted through airborne droplets, with children who are the most susceptible, particularly in the areas with poor tuberculosis control. The BCG vaccine, developed by Albert Calmette and Camille Guérin, has a history sp…
Liao Q, Zheng Y, Wang Y, Ye L, Liu X, et al.
Background Evidence varies regarding the efficacy of Bacillus Calmette-Guérin (BCG) vaccine. Data on protection by BCG vaccination against severe tuberculosis (TB) among children in China remain unclear. Methods We conducted a case-based, multicenter retrospective study at three …
O'Hara JM, Wakabayashi S, Siddiqi N, Cheung E, Babunovic GH, et al.
…ainst lung disease. Thus, there is an urgent need for novel vaccines. Here, we show that a multicomponent acellular vaccine (TB-MAPS) induces robust antibody responses and long-lived systemic and tissue-resident memory Th1, Th17, and cytotoxic CD4 + and CD8 + T cells, and promote…
Yang Y, Chen YZ, Xia T
…. Consequently, the exploration and development of novel TB vaccines, capable of providing broad protection to populations, have consistently constituted a prominent area of interest in medical research. This article presents a concise overview of the novel TB vaccines currently …
Tsujimura Y, Shiogama Y, Soma S, Okamura T, Takano J, et al.
…ogy that are used routinely to determine the efficacy of TB vaccines in nonhuman primate models might not correlate with the bacterial burden and histopathological score in the lung as measured in this study.
Koster KJ, Webb HL, Cirillo JD
Bacille Calmette-Guérin (BCG) vaccination, widely used throughout the world to protect against infant tuberculous meningitis and miliary tuberculosis (TB), can provide broad non-specific protection against infectious respiratory diseases in certain groups. Interest in BCG has see…
Aceves-Sánchez MJ, Flores-Valdez MA, Pedroza-Roldán C, Creissen E, Izzo L, et al.
A single intradermal vaccination with an antibiotic-less version of BCGΔBCG1419c given to guinea pigs conferred a significant improvement in outcome following a low dose aerosol exposure to M. tuberculosis compared to that provided by a single dose of BCG Pasteur. BCGΔBCG1419c wa…
Joosten SA, Ottenhoff THM, Lewinsohn DM, Hoft DF, Moody DB, et al.
…Mtb), but the optimal T-cell antigens to be included in new vaccines are not established. T-cells are often thought of as responding mainly to peptide antigens presented by polymorphic major histocompatibility complex (MHC) I and II molecules. Over the past two decades, the numbe…
White AD, Sibley L, Sarfas C, Morrison A, Gullick J, et al.
A single intradermal vaccination with MTBVAC given to adult rhesus macaques was well tolerated and conferred a significant improvement in outcome following aerosol exposure to M. tuberculosis compared to that provided by a single BCG vaccination. Vaccination with MTBVAC resulted …
Hansen SG, Zak DE, Xu G, Ford JC, Marshall EE, et al.
Despite widespread use of the bacille Calmette-Guérin (BCG) vaccine, tuberculosis (TB) remains a leading cause of global mortality from a single infectious agent (Mycobacterium tuberculosis or Mtb). Here, over two independent Mtb challenge studies, we demonstrate that subcutaneou…
Nieuwenhuizen NE, Kaufmann SHE
… involves the development of recombinant live mycobacterial vaccines with improved efficacy and safety. The second strategy is to boost BCG with subunit vaccines containing Mtb antigens. This article reviews recombinant BCG strains that have been tested against TB in animal model…
Xin Ge, Haoran Wang, Dingpu Liu, Yuhui Dong, Lin Li, et al.
Type II toxin-antitoxin (TA) systems are significantly expanded in thecomplex; however, the functional role of the VapBC40 system in() pathogenesis remains poorly characterized. This study aimed to investigate the role of VapBC40 in mycobacterial virulence and evaluate its potent…
Haoyan Yang, Xinkui Lei, Siyu Chai, Sigen Zhang, Guimin Su, et al.
… highlight the potential of adhesin-inclusive multi-epitope vaccines to elicit both humoral and cellular immunity and demonstrate how computational vaccinology can accelerate the development of targeted interventions against tuberculosis.
Sharifi G, Mousavinejad SA, Moradian K, Ebrahimzadeh K, Samadian M, et al.
Background Brain tuberculoma is a rare manifestation of tuberculosis especially in immunosuppressed patients. The definitive diagnosis may be difficult owing to mimicking brain tumors and the absence of the common presentation. Bacille Calmette-Guérin (BCG) vaccine is used for pr…
Brzezińska S, Zabost A, Borkowska-Tatar D, Klatt M, Goździk J, et al.
According to the World Health Organization (WHO), around 1 million children worldwide are diagnosed with tuberculosis each year. The Bacillus Calmette-Guérin (BCG) vaccine has been used around the world for over 100 years. The complications of the BCG vaccination can occur in abo…
Procianoy GS, Cotrim MW, Cia LO, Behar PRP
Pandemic-related disruptions led to lower Bacille Calmette-Guérin (BCG) vaccine coverage in Brazil. This study highlights a link between reduced vaccinations and increased tuberculosis pulmonary and extrapulmonary cases in infants. Addressing vaccine hesitancy and ensuring health…
D'Auria G, Hodzhev Y, Aceves-Sánchez MJ, Moya A, Panaiotov S, et al.
Background Bacillus Calmette-Guérin (BCG) remains the only vaccine to prevent tuberculosis (TB) during childhood, with relatively low to no efficacy against pulmonary TB in adolescents and adults. BCG consists of close to 15 different substrains, where genetic variations among th…
Liao TA, Lau A, Sunil J, Hytönen V, Hmama Z
Tuberculosis (TB) is a serious infectious disease and the only available vaccine M. bovis bacillus Calmette-Guérin (BCG) is safe and effective for protection against children's severe TB meningitis and some forms of disseminated TB, but fails to protect against pulmonary TB, whic…
Layton ED, Barman S, Wilburn DB, Yu KKQ, Smith MT, et al.
… of T cells known to be induced by whole cell mycobacterial vaccines, such as BCG, and show that lipid Ag-specific T cells are resident in the lungs, where they may contribute to protective immunity.
Qianfei Liu, Songnian Que, Yixuan Qiu, Mingxing Tang, Shaohua Liu, et al.
…toinfection is a key aspect of the development of effective vaccines and immunotherapies to eradicate tuberculosis. In this review, we delve into the overview of animal models of TB infection and the host's innate and adaptive immune responses toinfection. We discuss howis recogn…
Cha HG, Kim DG, Choi JH
Lymphadenopathy after coronavirus disease 2019 (COVID-19) vaccination is a common side effect that usually resolves within several days to weeks, and only observation is recommended. However, for prolonged lymphadenopathy, other possibilities, including malignancy or other lympho…
Zhang X, Pan L, Zhang P, Wang L, Shen Y, et al.
Background Our previous study revealed the transcriptome atlas of specific cell types in tuberculous meningitis (TBM) model mice injected with the BCG vaccine via scRNA sequencing. However, the activities of miRNAs in TBM at single-cell resolution remain to be explored. Method Ce…