Showing 176–200 of 200 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Tack I, Dumicho A, Ohler L, Shigayeva A, Bulti AB, et al.
…the program setting. Support is needed when introducing new regimens to train staff in the monitoring, management, and reporting of AEs.
Kumar G, Kumar M, Muni S, Kumar R, Shankar M, et al.
…tidrug resistance pulmonary tuberculosis on all-oral longer regimens took one spot and one morning sample of sputum as per standard protocol after completing two months of all-oral longer regimens and culturing it in liquid broth using Mycobacterium Growth Indicator Tube (MGIT) 9…
Sinha P, Jacobson KR, Horsburgh CR Jr, Acuña-Villaorduña C
…culosis (MDR-TB) has historically required longer treatment regimens that were associated with higher unfavorable outcomes and side effects rates compared with drug susceptible TB (DS-TB). During the last decade, several studies conducted mostly in high-incidence settings have sh…
Solomonia N, Vacharadze K
…the all anti-TB drugs and to build an appropriate treatment regimens based on complete individual DST profile in timely manner. Initial TB treatment regimen prescribed based on gDST results not in all cases may be compliant with complete DST profile, which may be detected based o…
Kokebu DM, Ahmed S, Moodliar R, Chiang CY, Torrea G, et al.
BACKGROUND: STREAM (Standardised Treatment Regimens of Anti-tuberculosis drugs for Multidrug-Resistant Tuberculosis) Stage 1 demonstrated non-inferior efficacy of a short regimen for rifampicin-resistant TB (RR-TB) compared to a long regimen as recommended by the WHO. The present…
Sodeifian F, Zangiabadian M, Arabpour E, Kian N, Yazarlou F, et al.
…ing the clinical and microbiological efficacy and safety of regimens containing TG in patients with drug susceptibility testing (DST)-confirmed MDR A. baumannii , published until December 30, 2022. Observational studies were included if they reported clinical and microbiological …
Olayanju O, Esmail A, Limberis J, Dheda K
…anid and bedaquiline in drug-resistant tuberculosis (DR-TB) regimens. Prospective long-term outcome data, including in HIV-infected persons, are unavailable.We prospectively followed up 122 South African patients (52.5% HIV-infected) with DR-TB and poor prognostic features betwee…
Cheraghi M, Amiri M, Andarzgoo S, Zarei F, Seghatoleslami ZS, et al.
…proaches. The persistence of MDR-TB has led to a demand for regimens that are more effective in improving treatment outcomes and controlling transmission. This systematic review and meta-analysis sought to examine the efficacy of linezolid (LZD) and bedaquiline (BDQ) in MDR-TB tr…
Wasmann RE, Masini T, Viney K, Verkuijl S, Brands A, et al.
Following infection with Mycobacterium tuberculosis , young children are at high risk of developing severe forms of tuberculosis (TB) disease, including TB meningitis (TBM), which is associated with significant morbidity and mortality. In 2022, the World Health Organization (WHO)…
Zhen Feng, Hailan Wu, Qian Li, Xiaoqiang Zhang, Qingfeng He, et al.
**OBJECTIVES:** High-dose rifamycin (HDR) regimens have demonstrated significant potential in tuberculosis (TB) treatment. This study aims to evaluate the efficacy and safety profile of different HDR regimens. **DESIGN:** Using a systematic review and Bayesian network meta-analy…
Ngoc NB, Vu Dinh H, Thuy NT, Quang DV, Huyen CTT, et al.
…ety of patients on longer injectable-based MDR-TB treatment regimens using active pharmacovigilance data. Method We conducted an observational, prospective study based on active pharmacovigilance within the national TB program. A total of 659 MDR-TB patients were enrolled and fol…
Jason E Cummings, Lisa K Woolhiser, Vincent Guglielmi, Ashely Romano, Samantha Pauly, et al.
…acy of bedaquiline, delamanid, and linezolid (BDL) and BPaL regimens in a high-burden preclinicalmouse model. Treatment with pretomanid and delamanid monotherapies and dual therapy with bedaquiline-linezolid was also conducted for comparison. Mice were treated for 2, 4, or 8 week…
Walsh KF, Souroutzidis A, Vilbrun SC, Peeples M, Joissaint G, et al.
Multidrug-resistant tuberculosis (MDR-TB) outcomes are poor partly because of the long treatment duration; the World Health Organization conditionally recommends a shorter course regimen to potentially improve treatment outcomes. Here, we describe the drug susceptibility patterns…
Klauss Villalva-Serra, Beatriz Barreto-Duarte, Moreno M Rodrigues, Artur T L Queiroz, Julio Croda, et al.
…iers towards the expansion of shorter patient-friendly drug regimens. In 2019, a Unitaid-led deal reduced rifapentine costs by over 70%, facilitating Brazil's implementation of 3 months of rifapentine+isoniazid (3HP), a short-course TPT regimen, in its public health system. We ev…
Marina Calamelli, Caterina Davoli, Roberta Gerami, Maurizio Gulletta, Sofia Lovatti, et al.
… efficacy. Further evidence is urgently required on shorter regimens such as BPaLM for the treatment of extrapulmonary tuberculosis involving the brain and bones.
Wamaka Kaminyoge, Reuben Simfukwe, Mwiza Singini, Norman Sitali, Felix P Chilunga
…B) face major treatment challenges. Although newer all-oral regimens have transformed adult TB care, their use in younger populations has largely been extrapolated from adult studies, despite important biologic and clinical differences. Systematic and up-to-date evidence on the e…
Nisa Maria, Annisa Lazuardi Larasati, Indri Yuliani Hamdani, Jin-Gun Cho, Jan-Willem C Alffenaar
…dies that reported AE data for bedaquiline-pretomanid-based regimens. In total, 14 studies from various countries were included in the analysis, comprising seven clinical trials, six implementation studies and one pharmacovigilance study. AE detection methods differed between cli…
He Y, Li X
Background Tuberculosis (TB) is one of the serious epidemics that highly threaten the global public health. To explore the treatment effect of Levofloxacin, Moxifloxacin, and Gatifloxacin contained in the conventional therapy regimen for pulmonary tuberculosis. Methods Medline, P…
Jouego CG, Gils T, Piubello A, Mbassa V, Kuate A, et al.
…of patients treated with STR, FQr-mTR and SLIr-mTR as final regimens, respectively. Three (0.6%) patients acquired FQr during treatment. Early mortality occurred in 4.1% (29/709) and was associated with being HIV positive, male sex and being underweight. Overall mortality was ass…
Mega TA, Usamo FB, Negera GZ
Background Abacavir (ABC) and Zidovudine (AZT) based regimens are the preferred first line nucleoside reverse transcriptase (NRTIs) backbones being widely utilized for managing HIV infection in children. However, there is a dearth of data regarding the clinical outcomes and assoc…
Khan U, Huerga H, Khan AJ, Mitnick CD, Hewison C, et al.
…At a time when programs were struggling to design effective regimens for the treatment of multidrug-resistant tuberculosis (MDR-TB), the marketing authorization of bedaquiline and delamanid was a critical development in the MDR-TB treatment landscape. However, despite their avail…
Hoogar V, Anil Kumar M, Hugara S
Background Tuberculosis case management has undergone various changes in recent years. Most of the decisions have been taken based on provider intelligence or perspective. It is essential to know the beneficiary perspective about the changes in RNTCP. DOTS providers are active wi…
E Birmingham, B Remmerie, I Leipoldt, I Eshun-Wilsonova, K Callewaert, et al.
**BACKGROUND:** Multidrug-resistant TB regimens are associated with higher risk of QT prolongation; understanding bedaquiline's (BDQ) role is crucial for safety and management. **METHODS:** We report a pre-specified secondary analysis of data from STREAM Stage 2 (ISRCTN18148631)…
Padmasawitri TIA, Saragih SM, Frederix GW, Klungel O, Hövels AM
…ew of economic evaluations on implementing new short-course regimens (SCR) for drug-sensitive and drug-resistant tuberculosis (TB), to explore how uncertainties due to the limited evidence in the studies were dealt with and to identify useful information for decision making from …
Putra ON, Yulistiani Y, Soedarsono S
Background A regimen containing bedaquiline-delamanid is recommended in management of drug-resistant tuberculosis (DR TB) to increase a success rate. However, this regimen was rare in a clinical setting due to a potential risk of QT prolongation. Several studies have reported the…