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Huiling Wang, Shiqi Xie, Shaoqiong Huang, Xuejiao Huang, Ying Zhang, et al.
: The development of effective tuberculosis (TB) vaccines beyond BCG remains an urgent global health priority, especially for prevention of pulmonary TB in adults. While most current strategies focus on enhancing T-cell immunity, the potential of trained immunity to broadly augme…
Hatherill M, White RG, Hawn TR
…worldwide than any single infectious pathogen, yet the only vaccine licensed against tuberculosis, Bacille Calmette Guerin (BCG) is approaching its centenary. Two recent advances in clinical tuberculosis vaccine development have invigorated the field. BCG revaccination of interfe…
Qiangsen Zhong, Xiaochun Wang, Yun Xu, Runlin Wang, Mingming Zhou, et al.
…, Rv3334, and Rv3406) in LTBI and evaluated the immunologic efficacy of a novel subunit vaccine, PB2-DIMQ (antigen PB2:Rv0470c-Rv1846c; adjuvant DIMQ: liposome dimethyl dioctadecylammonium bromide [DDA] + imiquimod [IMQ]). It was found that all five antigens were genera…
Nemes E, Scriba TJ, Hatherill M
…e of review To outline the need for a new tuberculosis (TB) vaccine; challenges for induction of vaccine-mediated protection in HIV-infected persons; and recent advances in clinical development. Recent findings HIV has a detrimental effect on T-cell function, polarization and dif…
Marimani M, AlOmar SY, Aldahmash B, Ahmad A, Stacey S, et al.
…nates into other host organs. The Bacillus Calmette-Guérin (BCG) vaccine is employed to provide immune protection against TB; however, its efficacy is dependent on the age, immune status and geographic location of vaccinated individuals. Advanced diagnostic approaches such as Gen…
Strong EJ, West NP
The current vaccine for tuberculosis (TB) is a live attenuated strain of Mycobacterium bovis (BCG) and while effective at reducing the potential for disseminated TB in young children its disease protection rates in adults is highly variable while it confers little protection agai…
Wongchana T, Songthap A
… (4) perceived severity of tuberculosis, (5) perceived self-efficacy of tuberculosis prevention, (6) perceived outcome of tuberculosis prevention, (7) social support of tuberculosis prevention, and (8) tuberculosis prevention behaviors. Frequencies, percentages, means, standard d…
Zhou CY, Yang YL, Han ZY, Chen YX, Liu HL, et al.
…geted control of them may be an effective method to improve vaccine efficacy and TB treatment. However, the biology and signal regulation mechanisms of MAIT cells in TB patients are still poorly understood. Previous studies have been limited by the lack of reagents to specificall…
Lin CH, Kuo SC, Hsieh MC, Ho SY, Su IJ, et al.
…ory of TB (aOR=2.08; 95% CI 1.19 to 3.63)). The presence of BCG scar was protective (aOR=0.66; 95% CI 0.51 to 0.85). Duration of diabetes and poor glycaemic control were unrelated to the risk of LTBI. Conclusion There was a moderately increased risk of LTBI in patients with diabe…
Zelner J, Murray M, Becerra M, Galea J, Lecca L, et al.
…r reducing TB incidence. In this manuscript, we compare the efficacy of targeting screening and IPT on high-risk household contacts of diagnosed TB cases, with less-targeted active screening approaches in Lima, Peru. Methods We conducted a population-based prospective cohort stud…