Showing 126–150 of 200 documents
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Hamada Y, Getahun H, Tadesse BT, Ford N
…g cause of morbidity and mortality among people living with HIV. HIV-associated TB disproportionally affects African countries, particularly vulnerable groups at risk for both TB and HIV. Currently available TB diagnostics perform poorly in people living with HIV; however, new di…
Kaplan R, Hermans S, Caldwell J, Jennings K, Bekker LG, et al.
…d over the last decade with an estimated coverage of 63% of HIV- positive patients in 2013. The influence of ART on the characteristics of the population of HIV-positive patients presenting to the primary care TB programme is unknown. In this study, we examined trends in CD4 coun…
Kushwaha S, Yadav R, Kumar R, Kumar S, Chauhan DS, et al.
…erum exosomal microRNAs in Indian patients with and without HIV-TB coinfection. Methods The pool samples of serum exosomes of study participants (HIV-TB coinfection, extra-pulmonary TB, HIV mono-infection, pulmonary TB) and healthy humans were processed for the isolation of total…
Kagujje M, Somwe P, Hatwiinda S, Bwalya J, Zgambo T, et al.
…ective To determine the prevalence of tuberculosis (TB) and HIV in 13 Zambian correctional facilities. Methods Cross-sectional study. Setting 13 correctional facilities in seven of the 10 provinces in Zambia. Participants All incarcerated individuals were eligible for TB and HIV …
Gannepalli A, Krishna AB, Baghirath PV, Vinay BH, Khaled S, et al.
Aims and objectives Human immunodeficiency virus (HIV)-related oral lesions are often an early finding, and they reflect the underlying immunosuppression, and tuberculosis (TB) coinfection can have further deteriorating effect. Hence, a cross-sectional study was conducted to eval…
Nisreen Khambati, Kattya Lopez Tamara, Elizabeth Nakabugo, Arthur Van Valkenburg, Jessica K Anderson, et al.
…gnosis of pulmonary tuberculosis (TB) in people living with HIV remains difficult. Since the first pathogen-host interaction in TB occurs in the upper airway, we hypothesized that host transcriptomic analysis on nasal specimens may identify novel diagnostic biomarkers. We aimed t…
Weber SF, Saravu K, Heller T, Kadavigere R, Vishwanath S, et al.
…f-care ultrasound (POCUS) for human immunodeficiency virus (HIV)-associated EPTB is applied in sub-Saharan Africa. This study aimed at evaluating the applicability of POCUS for diagnosing EPTB in HIV-positive and HIV-negative presumptive tuberculosis (TB) patients in India, a cou…
Moodley P, Martinson NA, Joyimbana W, Otwombe KN, Abraham P, et al.
Background HIV and tuberculosis (TB) independently cause an increased risk for venous thromboembolic disease (VTE): deep vein thrombosis (DVT) and/or pulmonary embolism (PE). Data from high HIV and TB burden settings describing VTE are scarce. The Wells' DVT and PE scores are wid…
Duffy FJ, Thompson EG, Scriba TJ, Zak DE
…d by co-infection with Mycobacterium tuberculosis (Mtb) and HIV, the leading cause of death for HIV-infected individuals. Improved characterization of Mtb/HIV coinfection as a distinct disease state may lead to better identification and treatment of affected individuals. Methods …
Broset E, Saubi N, Guitart N, Aguilo N, Uranga S, et al.
…in). With the aim of using MTBVAC as a vector for a dual TB-HIV vaccine, we constructed the recombinant MTBVAC.HIVA 2auxo strain. First, we generated a lysine auxotroph of MTBVAC (MTBVACΔ lys ) by deleting the lysA gene. Then the auxotrophic MTBVACΔ lys was transformed with the E…
Abdulkarim S, John S, Garba T, Basason H, Balogun P, et al.
…icating (dormant) state and the increasing global burden of HIV coinfection. Consequently, understanding the knowledge and perception of the population at risk of tuberculosis-HIV infection is essential to designing a strategy of intervention embraced by the target population. A …
Kegne TW, Anteneh ZA, Bayeh TL, Shiferaw BM, Tamiru DH
…dictors of mortality were not sufficiently studied among TB-HIV co-infected patients in Ethiopia. Objective This study aimed to investigate the survival rate and predictors of mortality among TB-HIV co-infected patients during TB treatment at public health facilities in Bahir Dar…
Umubyeyi Nyaruhirira A, Scholten JN, Gidado M, Suarez PG
… other infectious diseases, including tuberculosis (TB) and HIV. The authors reflect on experiences with GeneXpert technology for TB detection and opportunities for integration with other diseases. They also reflect on benefits and risks of integration. Placement of diagnostics i…
Armstrong-Hough M, Shelby T, Ggita J, Nangendo J, Gupta AJ, et al.
BACKGROUND Measuring stigma for TB and HIV in households undergoing contact investigation for TB is critical for understanding its impacts on health behaviours and identifying opportunities for intervention. However, standardised measurements for TB-HIV stigma in household contac…
Vecchione MB, Eiras J, Suarez GV, Angerami MT, Marquez C, et al.
…th among infectious diseases. Human immunodeficiency virus (HIV) infection is a main predisposing factor to TB reactivation. Individuals HIV-TB co-infected develop a chronic state of inflammation associated with hypothalamic-pituitary-adrenal (HPA) axis dysregulation. This result…
Kyi MS, Aung ST, Oo HN, Chongsuvivatwong V
…ces for tuberculosis (TB) and human immunodeficiency virus (HIV) are operated either fully (as one single unit) or partially (each vertical programme provides both services). OBJECTIVE To review the fully and partially integrated services for TB-HIV and to assess their TB treatme…
Bhering M, Duarte R, Kritski A
…orldwide in the number of TB cases and 19 th in terms of TB-HIV co-infected cases. This study aims at identifying clinical and demographic factors associated with unsuccessful treatment outcomes (loss to follow-up, treatment failure and death) of HIV-positive patients with multid…
Mabuza MP, Shumba C
…ssing the high burden of tuberculosis-human immune virus (TBHIV) co-infection, and this challenge is more pronounced in the province of KwaZulu-Natal which has one of the highest burdens of TB-HIV co-infection in the world. The study explored the experiences of doctors and nurses…
Benzekri NA, Sambou JF, Tamba IT, Diatta JP, Sall I, et al.
…ribute to poor adherence to both tuberculosis treatment and HIV antiretroviral therapy (ART). Interventions that target food insecurity have the potential to increase treatment adherence, improve clinical outcomes, and decrease mortality. The goals of this study were to compare t…
Alene KA, Viney K, Moore HC, Wagaw M, Clements ACA
…kground Tuberculosis (TB) and human immunodeficiency virus (HIV) are the leading causes of infectious-disease-related deaths in Ethiopia, but little is known about their spatial distribution across the country. The aim of this study was to investigate the spatial patterns of TB a…
Monreal-Robles R, González-González JA, Sordia-Ramírez J, Ruiz-Holguin E, Negreros-Osuna AA, et al.
…799 inpatients with TB infection. Seven patients (25%) were HIV-positive. Overall mortality was 35.7%, with the combined variable of haemoglobin P = 0.029). No difference in the need for surgery (28.6% vs. 47.6%, P = 0.662), occurrence of septic shock (14.3 vs. 23.8%, P = 1.00) o…
Eric Katagirya, Busisiwe Mlotshwa, Samuel Kyobe, Savannah Mwesigwa, Gaone Retshabile, et al.
**BACKGROUND:** HIV-tuberculosis (HIV-TB) coinfection poses a significant public health challenge among children in high-burden African regions. Most previous transcriptomic studies have concentrated on adults and non-African populations, primarily analyzing gene-level differenti…
Bakht Pari, Sumbal Khan, Ruby Khan
**BACKGROUND:** The syndemic of HIV and tuberculosis (TB) co-infection remains a critical global health challenge, particularly in resource-limited settings where conventional epidemiological models fail to capture the complex evolutionary dynamics between pathogens, hosts, and i…
Tornheim JA, Dooley KE
…view In the past few years, tuberculosis (TB) has overtaken HIV as the infectious disease with the highest global mortality. Successful management of this syndemic will require improved diagnostic tests, shorter preventive therapies, and more effective treatments, particularly in…
Zeru MA
Background TB/HIV co-infection is a major public health problem in many parts of the world. But the prevalence of co-infection was varies among countries.This study was designed to assess prevalence of TB/HIV co-infection and to determine its factors. Methods A retrospective stud…