Showing 126–150 of 185 documents
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Khoshnood S, Heidary M, Haeili M, Drancourt M, Darban-Sarokhalil D, et al.
…among people with HIV in 2016. The Bacille Calmette-Guerin (BCG) is the only available TB vaccine which fails to provide consistent protection against pulmonary TB in adults and adolescents despite being efficacious at protecting infants and young children from the most severe, o…
Eunkyung Shin, Jin-Seung Yun, Young-Ran Lee, Hye-Ran Cha, Soo-Min Kim, et al.
…on deaths worldwide in 2022. Bacillus Calmette-Guérin (BCG) is the only licensed vaccine against tuberculosis (TB); however, it has limited protective efficacy in adults. In this study, we constructed a recombinant vaccinia virus expressing Ag85B from M. tuberculosis using a…
Kirk NM, Huang Q, Vrba S, Rahman M, Block AM, et al.
…b) remains a major global health threat. The only available vaccine Bacille Calmette-Guérin (BCG) does not prevent adult pulmonary TB. New effective TB vaccines should aim to stimulate robust T cell responses in the lung mucosa to achieve high protective efficacy. We have previou…
Mukherjee N, Julián E, Torrelles JB, Svatek RS
The Mycobacterium bovis Bacillus Calmette et Guérin (BCG) vaccine was generated in 1921 with the efforts of a team of investigators, Albert Calmette and Camille Guérin, dedicated to the determination to develop a vaccine against active tuberculosis (TB) disease. Since then, BCG v…
Ning H, Kang J, Lu Y, Liang X, Zhou J, et al.
Bacillus Calmette-Guérin (BCG) is a licensed prophylactic vaccine against tuberculosis (TB). Current TB vaccine efforts focus on improving BCG effects through recombination or genetic attenuation and/or boost with different vaccines. Recent years, it was revealed that BCG could e…
Naqvi N, Ahuja Y, Zarin S, Alam A, Ali W, et al.
The BCG vaccine represents a significant milestone in the prevention of tuberculosis (TB), particularly in children. Researchers have been developing recombinant BCG (rBCG) variants that can trigger lasting memory responses, thereby enhancing protection against TB in adults. The …
Fan X, Zhao X, Wang R, Li M, Luan X, et al.
…-19 among infectious diseases. The Bacillus Calmette-Guérin vaccine (BCG), the only licensed TB vaccine, is ineffective against adult TB. Therefore, there is an urgent need to develop new effective vaccines. Methods In this study, we developed a novel multistage subunit vaccine (…
Gyu Choi H, Woong Kwon K, Jae Shin S
…exemplified by SARS-CoV-2, has emphasized the importance of vaccines in thwarting infection and curtailing the progression of severe disease. The scourge of tuberculosis (TB), emanating from the Mycobacterium tuberculosis (Mtb) complex, has inflicted a more profound toll in terms…
Pelzer PT, Seeley J, Sun FY, Tameris M, Tao L, et al.
Recently, two Phase 2B tuberculosis vaccine trials reported positive efficacy results in adolescents and adults. However, experience in vaccinating these age groups is limited. We identified potential implementation strategies for the M72/AS01E vaccination and BCG-revaccination-l…
Sable SB, Posey JE, Scriba TJ
…ive use of the Mycobacterium bovis bacille Calmette-Guérin (BCG) vaccine. A safer and more effective vaccine than BCG is urgently required. More than a dozen TB vaccine candidates are under active evaluation in clinical trials aimed to prevent infection, disease, and recurrence. …
Xinfeng Li, Xinyu Tao, Mingyue Zhong, Yiyao Wang, Heng Xue, et al.
…n is a cornerstone of disease control, the only licensed TB vaccine, Bacille Calmette-Guérin (BCG), shows limited efficacy in adults. There is thus a critical need for more effective vaccines. Multi-epitope vaccines, which incorporate key epitopes from multiple antigens, off…
Alexa Giovanatti, Adrienne E Shapiro
…e leading infectious cause of death worldwide, yet the only vaccine currently available is the pediatric BCG, which has poor effectiveness in preventing TB in adolescents and adults. A TB vaccine for this older age group is projected to prevent 4.6-8.5 million deaths by 2050 and …
Wang X, Du J, Zhang Y, Zhu T, Mao L, et al.
… infectious disease worldwide, and Bacille Calmette-Guerin (BCG) remains the only TB vaccine licensed for clinical use. As there is little evidence that BCG is effective in adults, there is an urgent need for a safe and effective vaccine to control TB in adults. In this study, we…
Ji N, Mukherjee N, Reyes RM, Gelfond J, Javors M, et al.
Background Although intravesical BCG is the standard treatment of high-grade non-muscle invasive bladder cancer (NMIBC), response rates remain unsatisfactory. In preclinical models, rapamycin enhances BCG vaccine efficacy against tuberculosis and the killing capacity of γδ T cell…
Rodo MJ, Rozot V, Nemes E, Dintwe O, Hatherill M, et al.
…due to infectious disease, requires a highly efficacious TB vaccine. Many TB vaccine candidates are in pre-clinical and clinical development but only a few can be advanced to large-scale efficacy trials due to limited global resources. We aimed to perform a statistically rigorous…
Jackson S, McShane H
…ientific advancements, contributing to the licensure of new vaccines for many pathogens. Despite being one of the world's oldest known pathogens, there are still significant gaps in our knowledge surrounding the immunobiology of Mycobacterium tuberculosis (M. tb). Furthermore, th…
Cao X, Fu YX, Peng H
…portion of the world's population. The current tuberculosis vaccine, bacille Calmette-Guérin (BCG), offers limited protection against pulmonary tuberculosis in adults, underscoring the critical need for innovative vaccination strategies. Cytokines are pivotal in modulating immune…
Bianco C, Lesellier S, Barrat J, Richomme C, Boschiroli ML, et al.
…linical systemic dissemination of Bacillus Calmette-Guérin (BCG) is described in a captive badger (Meles meles) with lymphoma. An adult female European badger was vaccinated per os with BCG and after 8 weeks post-mortem examination identified marked lymphadenomegaly and multinodu…
Arinaminpathy N, Rade K, Kumar R, Joshi RP, Rao R
…e in meeting the end tuberculosis (TB) goals. While certain vaccine candidates in advanced stages of clinical trials raise hope for the future availability of new tools, in the immediate term, there is also increasing interest in Bacille Calmette-Guérin revaccination among adults…
Walker EM, Merino KM, Slisarenko N, Grasperge BF, Mehra S, et al.
Background Although BCG vaccine protects infants from tuberculosis (TB), it has limited efficacy in adults against pulmonary TB. Further, HIV coinfection significantly increases the risk of developing active TB. In the lack of defined correlates of protection in TB disease, it is…
Christine M Qabar, Allison W Roberts, Lucas M Waldburger, Edward E K Baidoo, Emine Akyuz Turumtay, et al.
…urgent need to develop a more efficacious anti-tuberculosis vaccine as the current live-attenuated vaccine strain BCG fails to prevent pulmonary infection in adults. In this study, we leverage a synthetic biology approach to engineer BCG to produce more (E)-4-hydroxy-3-methyl-but…
Shaista Arif, Farheen Aslam
…um tuberculosis (Mtb) has afflicted humanity for centuries. BCG is the only vaccine available for TB, but it shows limited protective efficacy in adults. Therefore, there is an urgent need to develop universal vaccines for controlling TB worldwide. In this study, four conserved m…
Ding X, Du W, Liu Q, Tao L, Shao Y, et al.
…PPD, and EC tests. In the second stage, to evaluate whether BCG vaccination affected the efficacy of skin tests, the participants with three negative results in the first stage were randomly assigned to the BCG and placebo groups at a ratio of 2:1 and underwent three tests. The p…
Joan Joseph-Munné, Milena Maya-Hoyos, Narcís Saubi, Santiago Perez, Miguel Angel Martinez Lopez, et al.
…Thus, the development of an effective, safe, and accessible vaccine for neonates and/or adults is an urgent need to prevent or control HIV infection or progression to AIDS. An effective HIV vaccine should induce long-lasting mucosal immunity, broadly neutralizing antibodies, inna…
Hernandez-Pando R, Shin SJ, Clark S, Casonato S, Becerril-Zambrano M, et al.
…he major threats to global human health. The only available vaccine ( Mycobacterium bovis BCG) protects children from disseminated forms of TB but does not effectively protect adults from the respiratory form of the disease, making the development of new and more-efficacious vacc…