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Sharma RK, Kumari U, Kumari N, Kumar R
Introduction Multi-drug-resistant tuberculosis (MDR-TB) has become a major public health concern globally. Mutations in first- and second-line drug targets such as katG, inhA, rpoB, rrs, eis, gyrA, and gyrB have been associated with drug resistance. Monitoring predominant mutatio…
Cornelius Gweba, Adegboyega Omoniyi Oyefabi, Abimbola Awopeju, Regina Doro Jabaka, Leonard Ighodalo Uzairue
**INTRODUCTION:** The emergence of multidrug-resistant tuberculosis has eroded the gains made in the fight against tuberculosis. This review aims to provide current perspectives on the lineages of thecomplex (MTBC) associated with drug-resistant tuberculosis (DR-TB) in Africa. *…
Arockiaraj J, Karthik R, Michael JS, Amritanand R, David KS, et al.
…s the role of Xpert MTB/RIF assay in early detection of MDR tuberculosis. Overview of literature MDR tuberculosis is increasing globally. The World Health Organization (WHO) has strongly recommended Xpert MTB/RIF assay for early detection of tuberculosis. Methods From 2006 to 201…
Ibrahim MB, Shaikh RH, Jahangir A, Khan AH, Noor H
Tuberculosis is more frequently found among high-risk populations in the United States. It has a challenging diagnosis since it can present with diverse organ involvement that may delay the diagnosis. This is especially true regarding hepatic tuberculosis, with prevalence varying…
Mokrousov I, Vyazovaya A, Akhmedova G, Solovieva N, Turkin E, et al.
…carbazone approved for the treatment of multidrug-resistant tuberculosis (MDR-TB) in Russia and some other countries. The ethA and hadABC mutations may confer PCZ resistance. At the same time, ethA mutations are known to mediate resistance to ethionamide (ETH) and prothionamide (…
Mok J, Kang BH, Kim HJ, Lee SJ, Lee T, et al.
…valence of and trends in drug resistance in extra-pulmonary tuberculosis (EPTB) and pulmonary tuberculosis (PTB). Methods We retrospectively analysed the results of phenotypic drug susceptibility testing (DST) in culture-confirmed TB patients from January 2010 to December 2014 at…
Chekesa B, Singh H, Gonzalez-Juarbe N, Vashee S, Wiscovitch-Russo R, et al.
Background Extrapulmonary tuberculosis (EPTB) refers to a form of Tuberculosis (TB) where the infection occurs outside the lungs. Despite EPTB being a devastating disease of public health concern, it is frequently overlooked as a public health problem. This study aimed to investi…
Adejumo OA, Olusola-Faleye B, Adepoju V, Bowale A, Adesola S, et al.
…a is one of the 30 high burden countries for drug resistant tuberculosis (DR-TB). This study assessed the prevalence and factors associated with rifampicin resistant tuberculosis (RR-TB) in a secondary referral hospital in Lagos State Nigeria. Methods A retrospective review of pr…
Niharika Sharma, Beenu Joshi, Bhawna Sharma, Santosh Kumar, Keshar Kunja Mohanty, et al.
Tuberculosis (TB) remains a global health challenge as annual mortality rate due to drug resistant TB is increasing exponentially. This is mostly associated with the delayed diagnosis of Multidrug-resistant (MDR) or latent TB. Effective management of TB demands development of nov…
Mokrousov I, Pasechnik O, Vyazovaya A, Yarusova I, Gerasimova A, et al.
Background Mycobacterium tuberculosis population in Russia is dominated by the notorious Beijing genotype whose major variants are characterized by contrasting resistance and virulence properties. Here we studied how these strain features could impact the progression of pulmonary…
Mohammed KAS, Khudhair GS, Al-Rabeai DB
Drug-resistant Mycobacterium tuberculosis (DR-MTB) is a major health threat to human beings. This study aimed to evaluate the prevalence and drug resistance profile of MTB. Data were collected from 2,296 newly diagnosed, and 246 retreated tuberculosis (TB) patients who attended t…
Brandao AP, Pinhata JMW, Simonsen V, Oliveira RS, Ghisi KT, et al.
… Xpert MTB/RIF in Sao Paulo, Brazil, numerous Mycobacterium tuberculosis isolates presenting "rifampicin-resistant genotype with rifampicin-susceptible phenotype" were observed. Objective To evaluate the prevalence, rpoB mutations and transmission of M. tuberculosis resistant to …
Weerasuriya CK, Harris RC, McQuaid CF, Bozzani F, Ruan Y, et al.
…recent advances through the development pipeline, how novel tuberculosis (TB) vaccines might affect rifampicin-resistant and multidrug-resistant tuberculosis (RR/MDR-TB) is unknown. We investigated the epidemiologic impact, cost-effectiveness, and budget impact of hypothetical no…
Maulina N, Hayati Z, Hasballah K, Zulkarnain Z, Waraztuty I, et al.
Background Indonesia has the second highest tuberculosis (TB) cases globally. This study aimed to determine the sociodemographic factors associated with TB and rifampicin-resistant tuberculosis (RR-TB) cases among presumptive pulmonary TB patients in Aceh Referral Hospital. Study…
Wang Y, Liu Y, Long M, Dong Y, Li L, et al.
…cellular matrix and the consequent release of Mycobacterium tuberculosis into the airways. Recent studies indicate that kallikrein-related peptidase 12 (KLK12) regulate MMP-1 and MMP-9, suggesting that targeting the KLK12 gene could be a promising tuberculosis (TB) treatment. To …
Madamarandawala P, Rajapakse S, Gunasena B, Madegedara D, Magana-Arachchi D
Background Tuberculosis (TB), caused by the bacterium Mycobacterium tuberculosis is one of the top thirteen causes of death worldwide. The major challenge to control TB is the emergence of drug-resistant tuberculosis (DR-TB); specifically, multi-drug resistant TB which are resist…
Napier G, Campino S, Phelan JE, Clark TG
…INH) and rifampicin (RIF) first-line drugs in Mycobacterium tuberculosis (Mtb), together called multi-drug resistance, threatens tuberculosis control. Resistance mutations in katG (for INH) and rpoB (RIF) genes often come with fitness costs. To overcome these costs, Mtb compensat…
Tao NN, Li YF, Song WM, Liu JY, Zhang QY, et al.
…as designed to identify the risk factors for drug-resistant tuberculosis (DR-TB) and the association between comorbidity and drug resistance among retreated pulmonary tuberculosis (PTB). Design A retrospective study was conducted among all the 36 monitoring sites in Shandong, Chi…
Xiang-Dong Wang, Dongmei Niu, Wei Lv, Lei Wang, Chen-Yu Zhang, et al.
… recently emerged as promising biomarkers for Mycobacterium tuberculosis (Mtb). However, little is known about the expression patterns and combined diagnostic potential of M. tuberculosis-derived sRNA (TB-sRNA) and endogenous miRNA in the circulation of patients with multidrug-re…
Madaki S, Mohammed Y, Rogo LD, Yusuf M, Bala YG
Objectives Drug resistance in tuberculosis (TB) is a very important public health threat that should not be ignored. Understanding the gender, age, and characteristics of individuals affected by TB (without HIV, diabetes, or hepatitis B complications), particularly in terms of dr…
Che Y, Lin Y, Yang T, Chen T, Sang G, et al.
Setting Controlling drug-resistant tuberculosis in Ningbo, China. Objective Whole-genome sequencing (WGS) has not been employed to comprehensively study Mycobacterium tuberculosis isolates, especially rifampicin-resistant tuberculosis , in Ningbo, China. Here, we aim to character…
Mbelele PM, Mbelele PM, Sauli E, Mpolya EA, Mohamed SY, et al.
Objectives Differences among Mycobacterium tuberculosis complex (MTC) species may predict drug resistance or treatment success. Thus, we optimised and deployed the genotype MTBC assay (gMTBC) to identify MTC to the species level, and then performed comparative genotypic drug-susc…
Htun YM, Khaing TMM, Yin Y, Myint Z, Aung ST, et al.
… associated factors among patients with multidrug-resistant tuberculosis. Methods A cross-sectional study was conducted at Yangon Regional Tuberculosis Centre, Myanmar. Data were collected by face-to-face interviews and treatment-card reviews of all adult patients who had registe…
Lee S, Kim MJ, Lee SH, Kim HY, Kim HS, et al.
In the future, tuberculosis (TB) will place a heavy burden on the aging population in Korea. To prepare for this crisis, it is important to analyze the disease burden trend of drug-susceptible tuberculosis (DS-TB) and multidrug-resistant tuberculosis (MDR-TB). Measuring disabilit…
Bajrami R, Mulliqi G, Kurti A, Lila G, Raka L
Background Drug-resistant tuberculosis (TB) continues to threaten TB control and remains a major global public health concern. The poor patient adherence in TB treatment is the cornerstone of emerging multidrug-resistant TB (MDR-TB). The aim of this study was to evaluate the resi…