Showing 101–125 of 200 documents
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Engel N
…ted in global innovation practices for tuberculosis and HIV diagnostics, and to what effect. It examines the development of point-of-care (POC) diagnostics - promised to be designed for users outside laboratories or in resource constrained settings - to study what developers and …
Yadav D, Garg RK, Chhabra D, Yadav R, Kumar A, et al.
…resent work illustrates the promising intervention of smart diagnostics devices through artificial intelligence (AI) and mechanobiological approaches in health care practices. The artificial intelligence and mechanobiological approaches in diagnostics widen the scope for point of…
Zhang Y, Zhan B, Hao X, Wang W, Zhang X, et al.
Purpose Tuberculosis is a high-burden disease and a major health concern in China, especially among children and adolescents. The purpose of this study was to assess risk factors for diagnostic delay in students with pulmonary tuberculosis in Quzhou City in eastern China. Patient…
Yuvarajan S, Praveen Radhakrishnan, Durga Krishnamurthy, Navya Cherukkumalli, Sagana Ravikumar
**BACKGROUND:** Sarcoidosis is a complex, multisystem granulomatous disease of unknown etiology, often presenting a diagnostic challenge due to its highly variable clinical manifestations and its overlap with infectious and neoplastic diseases. This is especially problematic in r…
Lin D, Wang X, Li Y, Wang W, Li Y, et al.
The prevalence of drug-resistant Mycobacterium tuberculosis (Mtb) strains makes disease control more complicated, which is the main cause of death in tuberculosis (TB) patients. Early detection and timely standard treatment are the key to current prevention and control of drug-re…
Limsrivilai J, Pausawasdi N
Differentiating Crohn's disease (CD) from intestinal tuberculosis (ITB) is a diagnostic dilemma, particularly in regions where ITB is prevalent and CD incidence is increasing, because both diseases can present quite similarly, and diagnostic tests to identify Mycobacterium tuberc…
Chang Song, Chunyan Zhao, Dan Luo, Aichun Huang, Chaoyan Xu, et al.
**BACKGROUND:** Tuberculosis (TB) remains a major cause of death in HIV/AIDS patients, where diagnosis is complicated by atypical presentation and paucibacillary disease. Current diagnostic methods have limitations in speed or sensitivity. This study evaluates the diagnostic valu…
Takumi Kanokogi, Naohisa Urabe, Nozomi Tokita, Hinako Murakami, Masakazu Sasaki, et al.
The incremental diagnostic yield of consecutive sputum nucleic acid amplification tests (NAATs) for pulmonary tuberculosis (PTB) is not well established. We aimed to assess the diagnostic performance of one to three consecutive sputum NAATs in a non-high-tuberculosis-burden setti…
Di Gennaro F, Cotugno S, Guido G, Cavallin F, Pisaturo M, et al.
Background Tuberculosis (TB) remains a Global Health challenge, with diagnostic delays contributing significantly to its spread. This study investigates the differences in diagnostic delays between native and migrant TB patients in Italy, examining patient-related diagnostic dela…
Qanash S, Hakami OA, Al-Husayni F, Gari AG
Objective Flexible fiberoptic bronchoscopy (FFB) has become an essential procedure for diagnosing and managing various respiratory conditions. We aimed to assess the main indications, diagnostic yield, and safety of FFB in our institute. Methods A total of 216 patients who underw…
Banerjee R, Pal P, Girish BG, Reddy DN
Background The diagnosis of Crohn's disease (CD) can be delayed in clinical practice. In tuberculosis endemic areas, empirical anti-tubercular therapy further delays treatment. Aim(s) To assess risk factors for diagnostic delay and its impact on the long-term complications of Cro…
Ng KC, Meehan CJ, Torrea G, Goeminne L, Diels M, et al.
…s have adopted connectivity solutions that allow linking of diagnostics, real-time capture, and shared repository of these test results. However, these connected diagnostics and readily available test results are not used to their full capacity, as we have yet to capitalize on fu…
Qu H, Wang M, Wang Z, Ao G, Yuan X, et al.
Rationale and objectives This prospective study aimed to evaluate the diagnostic performance of dual-input computed tomography perfusion technique (DI-CTP) in identifying the bronchial-pulmonary artery fistula in patients tuberculosis with massive hemoptysis. Material and methods…
Hangxing Wang, Yuanchun Li, Lifan Zhang, Xiaoqing Liu
**BACKGROUND AND OBJECTIVES:** Patients with rheumatic immune diseases (RD) are considered a high-risk population for developing active tuberculosis (ATB). Timely and accurate diagnosis of ATB in RD patients is critical for optimizing treatment outcomes and improving prognosis. B…
Andama A, Somoskovi A, Mandel B, Bell D, Gutierrez C
…ug resistant TB. The ultimate goal is to improve laboratory diagnostics and better individualized managementof detected TB, and make an important contribution toward eliminating this global epidemic. RATIONALE: Tuberculosis persists as one of the world's most deadly infectious di…
Modlin SJ, Mansjö M, Werngren J, Ejike CM, Hoffner SE, et al.
…TB) reported as PZA-susceptible (PZA-S) by common molecular diagnostics. Phenotypic susceptibility testing (pDST) indicated PZA-R TB. Targeted Sanger sequencing reported wild-type PncA, indicating PZA-S TB. Whole Genome Sequencing (WGS) by PacBio and IonTorrent both detected dele…
Pape S, Gulma K, Shivalli S, Cleenewerck de Kiev L
Individuals entering incarceration are at high risk for infectious diseases, other ill conditions, and risky behavior. Typically, the status of active pulmonary tuberculosis (PTB) is not known at the time of admission. Early detection and treatment are essential for effective TB …
Cherian SV, Kaur S, Karanth S, Xian JZ, Estrada-Y-Martin RM
Introduction Electromagnetic navigational bronchoscopy (ENB) is an excellent tool to diagnose peripheral pulmonary nodules, especially in the setting of emphysema and pulmonary fibrosis. However, most of these procedures are done by interventional pulmonologists and academic tert…
Lucy Mupfumi, Tapson Nyondo, Judith Mzyece, Vincent Kampira, Moussa Condé, et al.
…eaching universal access to WHO-recommended rapid molecular diagnostics (WRDs) in a selection of African countries. Data for 24 African countries were sourced from the WHO Global TB database to evaluate the proportion of notified people with TB tested with a WRD between 2018 and …
Peng L, Dai L, Zhu M, Fang T, Sun H, et al.
Objectives The diagnosis of tuberculosis pleural effusion (TPE) remains challenging, traditional diagnostic tests have limited diagnostic efficacy. This study aimed to assess the diagnostic performance of pleural fluid (PF) lipoarabinomannan (LAM) in TPE. Methods A diagnostic met…
Robert Needle, Yang Yu, Hafid Soualhine, Catherine Yoshida, Lei Jiao, et al.
…ycobacterial (NTM) infections is accomplished by three main diagnostics methods: smear microscopy, culture, and molecular testing. Diagnostic algorithms used by laboratories can significantly impact clinical and infection control management. Current Canadian Tuberculosis Standard…
Brinkmann F, Hofgrefe J, Ahrens F, Weidemann J, Berthold LD, et al.
Background The differentiation between latent tuberculosis infection (LTBI) and tuberculosis (TB) relies on radiological changes. Confirming the diagnosis remains a challenge because typical findings are often missing in children. This study evaluates diagnostic sensitivity, spec…
Zhang J, Chen J, Zhang Y, Chen L, Mo W, et al.
…pathogen-based diagnoses and the inability of immunological diagnostics to detect active TB. Hence, it is urgent to develop new techniques to detect TB more accurate and earlier. This research aims to scrutinize and authenticate DNA methylation markers suitable for tuberculosis d…
Broger T, Koeppel L, Huerga H, Miller P, Gupta-Wright A, et al.
…ining sputum samples. Funding FIND, the Global Alliance for Diagnostics.
Engel N, Wolffs PFG
Diagnostics, including those that work at point-of-care, are an essential part of successful public health responses to infectious diseases and pandemics. Yet, they are not always used or fit intended use settings. This paper reports on key insights from a qualitative study on ho…