Showing 101–125 of 185 documents
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Jauro S, Larson EC, Gleim JL, Wahlberg BM, Rodgers MA, et al.
…tcomes in people living with HIV. Bacillus Calmette-Guérin (BCG), the only approved TB vaccine, is effective in infants, but its efficacy in adolescents and adults is limited. In this study, we investigated the immune responses elicited by BCG administered via i.v. or intradermal…
Yu J, Fan X, Luan X, Wang R, Cao B, et al.
…seriously affects human health. Until now, the only anti-TB vaccine approved for use is the live attenuated Mycobacterium bovis (M. bovis) vaccine - BCG vaccine, but its protective efficacy is relatively low and does not provide satisfactory protection against TB in adults. There…
Ahmed A, Rakshit S, Adiga V, Dias M, Dwarkanath P, et al.
BCG turns 100 this year and while it might not be the perfect vaccine, it has certainly contributed significantly towards eradication and prevention of spread of tuberculosis (TB). The search for newer and better vaccines for TB is an ongoing endeavor and latest results from tria…
Valencia-Hernandez AM, Zhao G, Miranda-Hernandez S, Segura-Cerda CA, Pedroza-Roldan C, et al.
Bacille Calmette-Guérin (BCG) remains the only licensed vaccine against tuberculosis (TB). While BCG protects against TB in children, its protection against pulmonary TB in adults is suboptimal, and the development of a better TB vaccine is a global health priority. Previously, w…
Méndez-Samperio P
…ous disease worldwide. Currently, Bacillus Calmette-Guérin (BCG) remains the only TB vaccine licensed for human use. This TB vaccine is effective in protecting children against severe military TB but offers variable protective efficacy in adults. Therefore, new vaccines against T…
Melkie ST, Arias L, Farroni C, Jankovic Makek M, Goletti D, et al.
…incomplete protection conferred by bacille Calmette-Guérin (BCG) vaccination against adult pulmonary TB, efforts to discover novel TB vaccines are ongoing. Efficacy studies from advanced TB vaccines designed to stimulate cell-mediated immunity failed to show protection, suggestin…
Zhuang L, Ye Z, Li L, Yang L, Gong W
…cause of mortality worldwide. Currently, the only available vaccine for TB prevention is Bacillus Calmette-Guérin (BCG). However, BCG demonstrates limited efficacy, particularly in adults. Efforts to develop effective TB vaccines have been ongoing for nearly a century. In this re…
Wang Y, Sun Y, Zheng Y, Yang Y, He L, et al.
…uses of human death in the world. Bacillus Calmette-Guérin (BCG) provides limited protection in adolescents and adults. To explore the factors reducing efficacy of BCG vaccine, we assess the impacts of interleukin (IL)-10 and alarmins S100A8/A9 on T-cell memory. We found that BCG…
Sihang Dong, Shuang Wu, Ke Liang, Hui Zhang, Fangzheng Guo, et al.
…URPOSE:** The only World Health Organization (WHO)-approved vaccine for tuberculosis (TB), Bacillus Calmette-Guérin (BCG), shows limited efficacy, particularly against adult pulmonary TB. Moreover, traditional subunit vaccines often suffer from poor immunogenicity. To addres…
Bhaskar A, Pahuja I, Negi K, Verma A, Ghoshal A, et al.
Bacille Calmette-Guerin (BCG) generates limited long-lasting adaptive memory responses leading to short-lived protection against adult pulmonary tuberculosis (TB). Here, we show that host sirtuin 2 (SIRT2) inhibition by AGK2 significantly enhances the BCG vaccine efficacy during …
Mustafa AD, Kalyanasundram J, Sabidi S, Song AA, Abdullah M, et al.
…ng prevented and controlled by the Bacille Calmette Guérin (BCG) vaccine, the protective efficacy is highly variable and substandard (0-80%) in adults. Therefore, novel and effective tuberculosis vaccine that can overcome the limitations from BCG vaccine need to be developed. Res…
Yuqin Xue, Chao Fan, Yun Huang, Ying Jin, Yijing Zheng, et al.
…, as the currently available Bacillus Calmette-Guérin (BCG) vaccine provides only limited protection against adult pulmonary TB. This study aimed to develop and evaluate a novel fusion vaccine that combines the safety of BCG, the broader antigenic repertoire of Mycobacterium…
Angelidou A, Conti MG, Diray-Arce J, Benn CS, Shann F, et al.
Background Bacille Calmette-Guérin (BCG), the live attenuated tuberculosis vaccine, is manufactured under different conditions across the globe generating formulations that may differ in clinical efficacy. Innate immune recognition of live BCG contributes to immunogenicity sugges…
Craig SR, Lahey T, Dixit A, Fordham von Reyn C
Background The current vaccine against tuberculosis, BCG, is effective when given in most TB-endemic countries at birth but has diminished efficacy against pulmonary TB after 15-20 years. As a result, new booster vaccines for adolescents and adults are being developed to realize …
Song D, Ji J, Yang S, Chen Z, Liu J, et al.
…s, remains a major global public health threat. The limited efficacy of the current Bacillus Calmette-Guérin (BCG) vaccine against adult pulmonary TB highlights the urgent need for improved vaccine strategies. To address this, we engineered a recombinant BCG strain, designated rB…
Mingming Zhang, Syed Luqman Ali, Yuan Tian, Aigul Abduldayeva, Shuang Zhou, et al.
…TB) remains a pressing global health crisis. The inadequate efficacy of the BCG vaccine against adult pulmonary TB underscores the urgent need for novel, effective vaccines. This study aimed to design a novel mRNA vaccine candidate against TB using a rational immunoinformatics ap…
Singh AK, Srikrishna G, Bivalacqua TJ, Bishai WR
Bacillus Calmette-Guérin (BCG) vaccine is an attenuated live strain of Mycobacterium bovis. It may be the most widely used vaccine in human history and is the only licensed human tuberculosis (TB) vaccine available. Despite its excellent safety history, a century of use in global…
Weng CH, Saal A, Butt WW, Bica N, Fisher JQ, et al.
…ited data on effective therapies. Bacillus Calmette-Guérin (BCG) vaccine, a live-attenuated strain derived from an isolate of Mycobacterium bovis and originally designed to prevent tuberculosis, has shown some efficacy against infection with unrelated pathogens. In this study, we…
Lázaro M Marques-Neto, Monalisa M Trentini, Ana Carolina R Moreno, Silas F Eto, Ana Carolina O Carvalho, et al.
… remains a global public health challenge, with the current BCG vaccine providing limited efficacy in adults, and available treatments being lengthy and debilitating. To overcome these challenges, we have previously developed a recombinant BCG strain expressing the detoxifiedHeat…
Szachniewicz MM, van den Eeden SJF, van Meijgaarden KE, Franken KLMC, van Veen S, et al.
…nd a quarter of the global population. The sole licensed TB vaccine, Mycobacterium bovis Bacillus Calmette-Guérin (BCG), shows variable efficacy, particularly among adolescents and adults, underscoring the pressing need for more effective vaccination strategies. The administratio…
Dongmei Song, Jing Ji, Shuo Yang, Zhaohang Chen, Jiahe Liu, et al.
…s, remains a major global public health threat. The limited efficacy of the current Bacillus Calmette-Guérin (BCG) vaccine against adult pulmonary TB highlights the urgent need for improved vaccine strategies. To address this, we engineered a recombinant BCG strain, designat…
Buyun Xu, Mengjuan Yuan, Lisa Yang, Lan Huang, Jingxin Li, et al.
…erculosis (MTB), is one of the leading infectious causes of adult mortality worldwide. The Bacillus Calmette-Guérin (BCG) vaccine is currently the only approved vaccine for TB prevention, but its protective efficacy against adult pulmonary TB is limited, and it lacks effecti…
Mansury D, Ghazvini K, Amel Jamehdar S, Badiee A, Tafaghodi M, et al.
Background Due to the ineffectiveness of the BCG vaccine, especially in adult pulmonary tuberculosis (TB), and variable efficacies against childhood forms of TB, developing an effective TB vaccine is a major priority in controlling this disease. The aim of this study was to evalu…
Gong W, Pan C, Cheng P, Wang J, Zhao G, et al.
…d the best approach to reduce the TB burden. Unfortunately, BCG, the only TB vaccine currently approved for use, offers some protection against childhood TB but is less effective in adults. Therefore, it is urgent to develop new TB vaccines that are more effective than BCG. Accum…
Yongqiang Li, Xiuping Jia, Jinhua Tang, Huilian Qiao, Jiani Zhou, et al.
…osis (TB) is a major global health threat, with the current(BCG) vaccine having limited efficacy against adult pulmonary disease. Trained immunity (TI) is a form of innate immune memory that enhances antimicrobial defense. It is characterized by the epigenetic and metabolic repro…