Showing 51–75 of 170 documents
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Ford N, Maher D, Rangaka MX, Baddeley A, Singh S, et al.
Purpose of review Guidelines developed by the WHO aim to provide recommendations to support best practice in health delivery, with a focus on low-income and middle-income countries. As part of the guideline development process, critical knowledge gaps are identified and one of th…
Swain S, Kumar A, Vishwakarma VK, Aayilliath K A, Mittal A, et al.
…and around 18-36 lakh develop active tuberculosis annually. Latent TB is defined as a state of persistent immune response to stimulation by Mycobacterium tuberculosis antigens with no evidence of clinically manifested active TB. The progression of a latent infection to active tub…
Alzahabi KH, Usmani O, Georgiou TK, Ryan MP, Robertson BD, et al.
…sulting with a mortality approximating 1.5 million. Current treatment guidelines recommend oral administration of a combination of first-line anti-TB drugs for at least 6 months. While efficacious under optimum conditions, 'Directly Observed Therapy Short-course' (DOTS) is not wi…
Faust L, Ruhwald M, Schumacher S, Pai M
… aims Despite the World Health Organization (WHO)'s updated guidelines on tuberculosis (TB) preventive treatment, the scale-up of TB preventive therapy remains low in many high-burden countries (HBCs). We conducted a survey to better understand the current status of policy implem…
Hargreaves S, Nellums LB, Johnson C, Goldberg J, Pantelidis P, et al.
Background Screening for latent tuberculosis infection (LTBI) in migrants is important for elimination of tuberculosis in low-incidence countries, alongside the need to detect blood-borne infections to align with new guidelines on migrant screening for multiple infections in Euro…
Migliori GB, Tiberi S, Tiberi S, Zumla A, Petersen E, et al.
…ntinuous flow of new research articles on MDR-TB diagnosis, treatment, prevention and rehabilitation requires frequent update of existing guidelines. This review is aimed at providing clinicians and public health staff with an updated and easy-to-consult document arising from con…
Wyndham-Thomas C, Dirix V, Goffard JC, Henrard S, Wanlin M, et al.
…jectives : To review the current knowledge on screening for latent tuberculosis infection (LTBI) in HIV-infected adults and provide specific guidelines for Belgium. Focus is given to who to test, which testing method to use, timing of screening and choice of LTBI treatment. Metho…
Brett K, Severn M
…ency in the majority (i.e., around 95%) of people, known as latent TB infection. People with latent TB do not have any symptoms, and cannot spread the TB infection to others, however, they can develop active TB disease., Active TB disease occurs when the TB bacteria overwhelm the…
Starke SJ, Martinez Rivera MB, Krishnan S, Shah M
…take on an expanded role in the diagnosis and management of latent tuberculosis infection (LTBI). Clinical practice guidelines and recommendations exist for LTBI management, but there is a need for innovative tools to improve medical students' and residents' knowledge of evidence…
Occhineri S, Matucci T, Rindi L, Tiseo G, Falcone M, et al.
…d Health Organization (WHO) determined to include PA in its guidelines for the treatment of rifampicin-resistant (RR), multi drug resistant (MDR) and pre-extensively drug resistant TB (pre-XDR-TB) with BDQ, LZD and Moxifloxacine (MFX) in a 6-month regimen. Although further studie…
Gröschel MI, van den Boom M, Migliori GB, Dara M
… the existing World Health Organization (WHO) documents and guidelines on childhood and adolescent TB and describe the outcomes of this regional meeting. National childhood and adolescent TB guidelines are available in 25% of Member States, while 33% reported that no such guideli…
Friedman A, DeGeorge KC
… demonstrated minimal clinical improvement after initiating treatment for COVID-19, further investigations uncovered concomitant reactivated TB. This case is helpful in underscoring the potential implications of the COVID-19 pandemic and current treatment guidelines on the global…
Joseph Sturman, Jyoti Baharani, Jed Ashman, Lorraine Harper, Adam F Cunningham, et al.
…tion in endemic countries. Patients with CKD generally have latent TB reactivation, rather thaninfection, which presents with atypical, non-pulmonary presentations leading to late diagnosis, poorer outcomes and a high risk of widespread transmission through haemodialysis units. T…
Fröberg G, Jansson L, Nyberg K, Obasi B, Westling K, et al.
Swedish National tuberculosis (TB) guidelines recommend screening of active and latent TB (LTBI) among pregnant women (PW) from high-endemic countries or with previous exposure to possibly improve early detection and treatment.We evaluated cascade of care of a newly introduced TB…
Fine S, Vecchio M, Filipe Goncalves Monteiro J, Vecchio E, Mao EJ
Background Biologic treatment for moderate to severe inflammatory bowel disease (IBD) places patients at risk for infectious complications. Tuberculosis (TB) infection and reactivation can lead to serious morbidity and mortality for immunosuppressed patients. As a result, guideli…
Siva Prasad Korikana, Sreenivasa Rao Battula, Naresh Konduru, Aravind Kurnool, Divya Kumar Vemuri, et al.
…pentine, an essential therapeutic agent for both active and latent tuberculosis (TB). The chromatographic separation was achieved on a YMC Pack C18 column (250 × 4.6 mm, 5 μm) using a gradient elution with Solvent A composed of phosphate buf…
Vadakkan Devassy T, K V S, Jacob A, Meleppat VM
…icating clinical status of paediatric oncology patients and treatment of infection with this bacilli is challenging in this subpopulation of patients because of ongoing immunosuppression and relative lack of published guidelines. Atypical presentations of tuberculosis in children…
Xi Wang, Shengfei Hu, Rui Hong, Xi Cheng, Ye Hong, et al.
…ptica spectrum disorder (NMOSD). Currently, no standardized guidelines exist for preventing hepatitis B reactivation (HBVr) or tuberculosis reactivation (TBr) during the use of B cell-depleting agents in patients with NMOSD who are at risk of HBVr or TBr. Furthermore, data on HBV…
Nair S, Brar I, K.P. G
…cribed in HIV infected patients. Developed countries, where guidelines on the treatment of PJP have been created have dramatically lower rates of latent and active TB than developing countries. PJP may obscure the diagnosis or delay the treatment of TB. Furthermore, treatment of …
Cheon J, Kim C, Park EJ, Ock M, Lee H, et al.
…culosis (TB) develops in approximately 10% of people with a latent tuberculosis infection (LTBI). TB guidelines recommend that LTBI screening and treatments target high-risk patients. Malignancies are not universally considered a high-risk factor for active TB. This study aimed t…
Sarah van de Berg, Andreas Beyerlein, Johannes Stephani, Beatrix Bäumler-Merl, Manuela Jäger, et al.
…ield of TB contact investigations, compliance with national guidelines and risk factors for infection among contacts.METHODSWe analysed anonymised data of TB patients and their contacts collected between 2018 and 2022 in Upper Bavaria, Germany. We assessed testing coverage, laten…
Katherine Timboe, J Brooks Jackson, Greta L Becker
…ding infectious cause of death globally. Although effective treatments are available, treatment length, drug toxicity, and the emergence of drug-resistant strains have challenged TB control efforts. Current clinical trials are focused on developing shorter, safer, and more effect…
Judi Chen, Weining Cao, Renfang Chen, Yong Ren, Tao Li
…an immunodeficiency virus (HIV) worldwide are infected with latent tuberculosis (TB). The aim of this study was to determine the rate of HIV infection in TB patients and its determinants in Wuxi City, China. TB patients attending health institutions (12 selected sites) for TB dia…
Chitnis AS, Cheung R, Gish RG, Wong RJ
…nic hepatitis B virus (CHB) infection can be prevented with treatment and vaccination, respectively. We reviewed epidemiology and guidelines for TB and CHB to inform strategies for reducing United States (U.S.) burden of both infections. Non-U.S.-born, compared to U.S.-born, pers…
Ronald LA, Campbell JR, Balshaw RF, Romanowski K, Roth DZ, et al.
Background Canadian tuberculosis (TB) guidelines recommend targeting postlanding screening for and treatment of latent tuberculosis infection (LTBI) in people migrating to Canada who are at increased risk for TB reactivation. Our objectives were to calculate robust longitudinal e…