Showing 51–75 of 192 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Moosa MS, Maartens G, Gunter H, Allie S, Chughlay MF, et al.
…We conducted a randomized, double-blind, placebo-controlled trial to assess the efficacy of intravenous NAC in hospitalized adult patients with anti-tuberculosis drug-induced liver injury (AT-DILI). The primary endpoint was time for serum alanine aminotransferase (ALT) to fall be…
Babalwa Zani, Lara Fairall, Inge Petersen, Naomi Folb, Arvin Bhana, et al.
…s a secondary analysis of data from a randomised controlled trial of depression management in 2002 adults receiving ART. We investigated the effects of sociodemographic characteristics, comorbidities, depression symptoms (Patient Health Questionnaire-9 (PHQ-9)), functional disabi…
Babalwa Zani, Lara Fairall, Inge Petersen, Naomi Folb, Arvin Bhana, et al.
…s a secondary analysis of data from a randomised controlled trial of depression management in 2002 adults receiving ART. We investigated the effects of sociodemographic characteristics, comorbidities, depression symptoms (Patient Health Questionnaire-9 (PHQ-9)), functional disabi…
Baluku JB, Ronald O, Bagasha P, Okello E, Bongomin F
…Web of Science, the Cochrane Central Register of Controlled Trials, mRCTs, Clinical trials.gov, and International Clinical Trials Registry Platform from inception to 31st December 2021. Among 110 eligible studies, 79 (238,316 participants) were included in the meta-analysis for s…
William J Burman, M Florencia Martins, David Flynn, James Johnston, Pranay Sinha, et al.
…atment completion but have not been the focus of late-phase clinical trials. We performed a scoping review to identify interventions to improve the safety and tolerability of rifampin-susceptible tuberculosis. Our objective was to determine what interventions have been evaluated …
Shi W, Hu Y, Zheng X, Ning Z, Wu M, et al.
…n alterations in gut microbiota composition and unfavorable clinical outcomes. Methods The study is a multicenter, observational prospective cohort study. Three study sites are purposively selected in the western (Sichuan Province) and eastern (Jiangsu Province and Shanghai) part…
Millard JD, Mackay EA, Bonnett LJ, Davies GR
… Methods We will search for randomised and quasi-randomised clinical trials in adult participants with and without the inclusion of PZA in TB treatment regimens in the Cochrane infectious diseases group's trials register, Cochrane central register of controlled trials (CENTRAL), …
Hills NK, Lyimo J, Nahid P, Savic RM, Lienhardt C, et al.
…osis (TB). However, the current practice in TB therapeutics trials is to use composite binary outcomes, which in the absence of standardization may inflate false positive and negative errors in evaluating regimens. The lack of standardization of outcomes is a barrier to the ident…
Xie F, Duan Z, Zeng W, Xie S, Xie M, et al.
… 159 CAP patients to assess the diagnostic performance of a clinical metagenomics assay and its impact on clinical management and patient outcomes. When compared to other techniques, clinical metagenomics detected more pathogens in more CAP cases, and identified a substantial num…
Manal Arshad Malik, Aleena Kamran, Dua Ahsan, Aafia Amjad, Sara Moatter, et al.
…d across major databases, including PubMed, Google Scholar, ClinicalTrials.gov, the WHO International Clinical Trials Registry Platform, and the ISRCTN Registry. The search strategy used terms like ("tubercular meningitis" OR "TBM" OR "TB meningitis") AND ("diagnosis" OR "treatme…
Ye Q, Wang H, Xia X, Zhou C, Liu Z, et al.
…ls (DPSCs) in treating severe pneumonia caused by COVID-19. Trial design This is a single centre, two arm ratio 1:1, triple blinded, randomized, placebo-controlled, parallel group, clinical trial. Participants Twenty serious COVID-19 cases will be enrolled in the trial from April…
Rudolf F, Abate E, Moges B, Mendes AM, Mengistu MY, et al.
Background The Bandim TBscore is a clinical score that predicts treatment outcome in Tuberculosis (TB) patients and proved useful as an indicator of which healthcare-seeking adults to refer for sputum smear microcopy. We aimed to test in a randomized trial if the TBscore could be…
Inbaraj LR, Manesh A, Ponnuraja C, Bhaskar A, Srinivasalu VA, et al.
… in the field of TBM over the last two decades and only few trials have evaluated a composite of these strategies in the overall outcomes of TBM. Methods An open label, parallel arms, randomized controlled superiority trial will be conducted among 372 participants across 6 sites …
Bjerrum S, Schiller I, Dendukuri N, Kohli M, Nathavitharana RR, et al.
…d symptoms).The proposed role for LF-LAM is as an add on to clinical judgement and with other tests to assist in diagnosing tuberculosis. Search methods We searched the Cochrane Infectious Diseases Group Specialized Register; MEDLINE, Embase, Science Citation Index, Web of Scienc…
Horne DJ, Kohli M, Zifodya JS, Schiller I, Dendukuri N, et al.
…n Health Sciences Literature, Scopus, the WHO International Clinical Trials Registry Platform, the International Standard Randomized Controlled Trial Number Registry, and ProQuest, to 11 October 2018, without language restriction. Selection criteria Randomized trials, cross-secti…
Mikashmi Kohli, Leeberk Raja Inbaraj, Angela Salomon, Katie Scandrett, Alexei Korobitsyn, et al.
…:** We searched the Cochrane Central Register of Controlled Trials, MEDLINE, Embase, Science Citation Index, Latin American Caribbean Health Sciences Literature, Scopus, ClinicalTrials.gov, the WHO International Clinical Trials Registry Platform, the International Standard Random…
Kohli M, Schiller I, Dendukuri N, Yao M, Dheda K, et al.
…atin American Caribbean Health Sciences Literature, Scopus, ClinicalTrials.gov, the WHO International Clinical Trials Registry Platform, the International Standard Randomized Controlled Trial Number Registry, and ProQuest, 2 August 2019 and 28 January 2020 (Xpert Ultra studies), …
Kohli M, Schiller I, Dendukuri N, Dheda K, Denkinger CM, et al.
…ican Caribbean Health Sciences Literature (LILACS), Scopus, ClinicalTrials.gov, the WHO International Clinical Trials Registry Platform, the International Standard Randomized Controlled Trial Number (ISRCTN) Registry, and ProQuest up to 7 August 2017 without language restriction.…
Xiong K, Cai J, Liu P, Wang J, Zhao S, et al.
…ug-induced liver injury in animal experiments. However, the clinical evidence is absent. The objective is to investigate the effect of adjunctive Lactobacillus casei on tuberculosis-drug-induced liver injury. Methods and results A post hoc analysis is conducted for a previous ran…
Shivalli S, Hondappagol A, Akshaya KM, Nirgude A, Varun N, et al.
…This is a pragmatic, prospective, non-randomised controlled trial in two pairs of RNTCP Designated Microscopy Centres (located at secondary and primary healthcare facilities) of Dakshina Kannada district, India. Presumptive pulmonary TB patients aged ≥18 years will be included. W…
Ashwin Karnan, Ulhas Jadhav, Babaji Ghewade, Vivek Alone
…y with slightly better adherence in the shorter regimen. **CLINICAL TRIAL REGISTRATION:** The study was registered in the Clinical Trials Registry-India (Indian Council of Medical Research-National Institute of Medical Statistics), https://ctri.nic.in/, CTRI registration number …
Tadesse AW, Mohammed Z, Foster N, Quaife M, McQuaid CF, et al.
…gn We will conduct a pragmatic three-arm cluster-randomised trial with 78 health facilities in two regions in Ethiopia. Facilities are randomised (1:1:1) to either of the two intervention arms or standard of care. Adults aged ≥ 18 years with drug-sensitive (DS) pulmonary TB are e…
Jahnke N, Waters V, Ratjen F, Smith S, Hambleton IR, et al.
…(CF). Search methods We searched Cochrane's Cystic Fibrosis Trials Register, online databases (MEDLINE, Embase and PubMed) and online trials registries (www. Clinicaltrials gov and the World Health Organization International Clinical Trials Registry). We also searched the referen…
Geetanjali Chander, Nishi Suryavanshi, Nikhil Gupte, Gauri Dhumal, Shatabdi Bagchi, et al.
…outcomes. This paper describes the protocol for HATHI,ybrid trial forlcohol reduction among people withB andIV inndia, a Hybrid Type 1 effectiveness-implementation trial, that tests if a behavioral intervention integrated into TB and HIV treatment, compared to usual care, results…
Kay AW, González Fernández L, Takwoingi Y, Eisenhut M, Detjen AK, et al.
…dered age, disease severity, smear-test status, HIV status, clinical setting, specimen type, high tuberculosis burden, and high tuberculosis/HIV burden - For detection of rifampicin resistance, we considered multi-drug-resistant tuberculosis burden • To compare multiple Xpert MTB…