Showing 26–50 of 170 documents
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Yoopetch P, Anothaisintawee T, Gunasekara ADM, Jittikoon J, Udomsinprasert W, et al.
…f three network meta-analyses (NMA) examining the efficacy, treatment completion, and adverse events associated with all latent tuberculosis infection (LTBI) treatments, there is currently no evidence to support the notion that the benefits of these treatments outweigh the potent…
Swinkels HM, Jilani TN, Tobin EH
…tory. Long considered an infection without a known cause or treatment, disease understanding has rapidly progressed. Robert Koch discovered the Mycobacterium tuberculosis bacterium (Mtb) in 1882, and, just over 100 years later, its complete genome sequence was mapped. Today, cont…
Marks SM, Self JL, Venkatappa T, Wolff MB, Hopkins PB, et al.
…tion and control among PEH. Our goal was to provide current guidelines and information in one place to inform medical and public health providers and TB programs on TB incidence, diagnosis, and treatment among PEH. Methods We reviewed and synthesized diagnostic and treatment reco…
Burguet L, Duvignaud A, Nguyen D, Receveur MC, Kaminski H, et al.
…rding to their level of priority. In those with evidence of latent TB infection, treatment decision was based on the level of exposure, individual vulnerability, as well as the results of an interferon-gamma release assay. Results A total of 130 patients with CKD and 180 KTR were…
O'Connell J, de Barra E, McNally C, McConkey S
Aim Knowledge of latent tuberculosis infection (LTBI) screening and treatment practices are lacking in Ireland, where LTBI is not programmatically surveyed or managed. The aim of this research was to describe current clinical practice when screening and treating patients for LTBI…
Hashim Z, Tyagi R, Singh GV, Nath A, Kant S
…prevention of the development of active disease by treating latent TB infection (LTBI). The guidelines for the same were already provided by the WHO and were then adapted in the Indian guidelines for the treatment of LTBI in 2021. While the long-term impact of TBI treatment is aw…
Miranda-Schaeubinger M, Derbew HM, Ramirez A, Smith M, Jalloul M, et al.
…the United States, positive PPD is sufficient to treat for "latent" TB, or TB infection in asymptomatic patients. Objective We sought to determine frequency of abnormal CXR findings after a positive purified protein derivative (PPD) test at a tertiary pediatric center in the Unit…
Godoy P
Objectives Latent TB infection (LTBI) affects 25% of the world's population. As long as this reservoir exists, the elimination of TB will not be feasible. The Assembly of the World Health Organization adopted the "Global End TB" strategy for the elimination of TB in 2014. The obj…
Surve S, Naukariya K, Shah I
… review various studies conducted in relation to diagnosis, treatment and management of Latent TB Infection (LTBI) in under-five children, thus highlighting research gaps and further scope of improvements with respect to Indian context. The methodology involved literature review …
Awad SF, Critchley JA, Abu-Raddad LJ
… DM status, TB infection status and stage, TB disease form, treatment, recovery, and intervention status. Results By 2050, different TB vaccination strategies (coverage of 50 % and vaccine efficacies ranging between 50 %-60 %) reduced TB incidence and mortality rates by 4.5 %-20.…
Kim HW, Kim JS
The role of the treatment for latent tuberculosis infection (LTBI) has been underscored in the intermediate tuberculosis (TB) burden countries like South Korea. LTBI treatment is recommended only for patients at risk for progression to active TB-those with frequent exposure to ac…
Wells C, Severn M
…rium Mycobacterium tuberculosis. Initial infection leads to latent TB, which has no active symptomology as the disease is contained by the host’s immune defences. However, in a small subset of infected patients (5% to 10%), the infection can proceed to active TB, which has visibl…
Song YJ, Cho SK, Kim H, Kim HW, Nam E, et al.
…f developing tuberculosis (TB). This requires diagnosis and treatment of latent tuberculosis infection (LTBI). We aimed to evaluate whether diagnosis and treatment of LTBI in RA are effective in Korea, and to estimate the risk of TB development by calculating the incidence rate o…
Li Y, Marks SM, Beeler Asay GR, Winston CA, Pepin D, et al.
…the United States, older adults have elevated prevalence of latent tuberculosis infection (LTBI) and incidence of tuberculosis (TB). Objective To estimate the health benefits and cost-effectiveness of LTBI testing and treatment among the Medicare-eligible population. Design Model…
Flynn MG, Rees MA, Saqib A
Australian guidelines recommend the tuberculin skin test (TST) as the preferred test for latent tuberculosis infection (LTBI) with interferon-gamma release assay (IGRA) as a supplemental test to improve specificity. For many years the chest radiograph has been used to interpret a…
Akanksha Sirohi, Yash Vardhan Trivedi, Tavishi Katoch, Benjamin Walters, Vasu Bansal, et al.
…, focusing on high-risk populations, current diagnostic and treatment strategies, and the importance of addressing clinical and social determinants of health to achieve TB elimination goals.MethodsA review of the latest evidence-based guidelines and literature on TB diagnostics, …
Sharma N, Basu S, Chopra KK, Sharma P
… two healthcare workers (HCWs) in developing countries have latent tuberculosis infection (LTBI), an asymptomatic condition signifying persistent tubercular infection in absence of disease. Objective to evaluate the physician attitude towards LTBI preventive therapy and their per…
Cerrone M, Bracchi M, Wasserman S, Pozniak A, Meintjes G, et al.
… Early initiation of antiretroviral therapy (ART) during TB treatment improves survival in patients with advanced HIV disease. However, safety concerns related to clinically significant changes in drug exposure resulting from drug-drug interactions, development of overlapping tox…
Stewart RJ, Wortham J, Parvez F, Bamrah Morris S, Kirking HL, et al.
…creasingly unfamiliar with TB and the recommended tests and treatment for latent TB infection. Compared with adults, children who develop TB more often develop severe disease, and children < 2 years are particularly susceptible to developing TB disease after initial infection. Nu…
Rupani MP, Balachandar R, Kharkwal G, Kulkarni NP, Modi BV, et al.
The 2021 tuberculosis (TB) preventive treatment guidelines in India included silicosis as a screening group, yet latent TB infection (LTBI) testing for silica-dust-exposed individuals is underemphasized. Focusing on an estimated 52 million silica-dust-exposed workers, particularl…
Okada RC, Barry PM, Skarbinski J, Chitnis AS
…ns of TB exposures in US dialysis facilities, and published guidelines to inform screening and treatment practices among US ESRD patients. Compared to TB in the general population, ESRD patients have 6-25-fold higher TB incidence rates, and mortality during treatment is 2-3-fold …
Rickman HM, Rickman HM, Miller RF, Morris-Jones S, Kellgren L, et al.
United Kingdom guidelines recommend screening for and treatment of latent tuberculosis infection (LTBI) in HIV-positive patients at high risk of active tuberculosis (TB) disease, but implementation is suboptimal. We investigated potential missed opportunities to identify and trea…
Rebecca F Baggaley, Christopher A Martin, Helen C Eborall, Marjan Gohar, Kashif Aziz, et al.
…ing clinic, 7% (31/437) had active TB and 92% (403/437) had latent TB infection. Seventeen (55%) active TB, 397 (99%) latent TB, 71 (61%) HBV, six (35%) HIV and five (83%) HCV infections were new diagnoses. There were high rates of linkage to care for those newly diagnosed. 98% (…
Ronald LA, Campbell JR, Rose C, Balshaw R, Romanowski K, et al.
Background Latent tuberculosis infection (LTBI) screening and treatment is a key component of the World Health Organization (WHO) EndTB Strategy, but the impact of LTBI screening and treatment at a population level is unclear. We aimed to estimate the impact of LTBI screening and…
Mandal S, Bhatia V, Sharma M, Mandal PP, Arinaminpathy N
…ines in TB burden. The 2018 World Health Organization (WHO) guidelines on eligibility for preventive therapy to treat latent TB infection (LTBI) include people living with human immunodeficiency virus (PLHIV), household contacts of TB patients including children, and those with c…