Showing 26–50 of 200 documents
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Che Y, Yang T, Lin L, Xiao Y, Jiang F, et al.
Setting: Programmatic management of drug-resistant tuberculosis in Ningbo, China. Objective: To assess whether data-driven genetic determinants of drug resistance patterns could outperform phenotypic drug susceptibility testing in predicting clinical meaningful outcomes among pat…
Shah V, Yogesh M, Kothari DR, Gandhi RB, Nagda JJ
Background Characterizing risk factors for drug-resistant tuberculosis (TB) is critical to guide targeted interventions in high-burden settings like India. We aimed to identify socioeconomic, lifestyle, and clinical factors associated with drug-sensitive and drug-resistant TB acq…
Xu P, Li M, Jiang Q, Yang C, Liu X, et al.
Objective Drug resistance is the critical determinant for appropriate tuberculosis (TB) treatment regimens and an important indicator of the local TB burden. We aimed to investigate and compare trends in TB drug resistance in the urban Songjiang District of Shanghai from 2011 to …
Song T, Li LJ, Liu JL, Geng SJ
… TNF-α in the peripheral blood of patients affected by multidrug-resistant and extensively drug-resistant tuberculosis. Patients and methods 179 patients suffering from tuberculosis treated in the Chest Hospital of Hebei from April 2010 to December 2015 were selected for the stud…
Paryani RH, Gupta V, Singh P, Verma M, Sheikh S, et al.
… is high among household contacts (HHCs) of pre-extensively drug resistant (pre-XDR) TB and XDR-TB, data on yield of systematic longitudinal screening are lacking. We aim to describe the yield of systematic longitudinal TB contact tracing among HHCs of patients with pre-XDR-TB an…
Wei Wang, Yuxin Gao, Yong Gao, Tuantuan Li, Yan Liu, et al.
**OBJECTIVE:** This study aimed to analyze drug resistance patterns and inpatient medication utilization among drug-resistant tuberculosis (DR-TB) patients in Fuyang City (2021-2023), and to identify factors associated with unsuccessful treatment outcomes in multidrug-resistant t…
Che Y, Lin Y, Yang T, Chen T, Sang G, et al.
Setting Controlling drug-resistant tuberculosis in Ningbo, China. Objective Whole-genome sequencing (WGS) has not been employed to comprehensively study Mycobacterium tuberculosis isolates, especially rifampicin-resistant tuberculosis , in Ningbo, China. Here, we aim to character…
Bwire Wilson Bwire, Maurice C Y Mbago, Amina S Msengwa
**BACKGROUND:** The prevalence of tuberculosis (TB) multi-drug resistance is increasing worldwide, including in Tanzania. This trend hinders the attainment of sustainable development goal number three as it increases the number of cases of the disease and treatment costs. Fewer c…
Chen Yang, Guangchuan Dai, Yicheng Guo, Tianzhen Wang, Weiwei Gao, et al.
**BACKGROUND:** Drug-resistant tuberculosis has emerged as a major public health issue that requires immediate attention. NTS is an innovative method that allows for the direct detection of clinical samples without the need for culture. It could provide more accurate, reliable, a…
LaFreniere M, Hussain H, Vachon J
Background Drug-resistant tuberculosis (TB) is a global public health issue. To monitor this in Canada, surveillance systems have been in place for the last 20 years. Objective To describe drug resistance patterns among TB isolates in Canada in 2017 by type of resistance as well …
Ei PW, Aung WW, Nyunt WW, Swe TL, Htwe MM, et al.
…nmar. Objectives To determine the proportion of extensively drug-resistant TB (XDR-TB) cases among multidrug-resistant TB (MDR-TB) cases and the mutations that cause resistance to second-line drugs in Myanmar. Design This was a cross-sectional, retrospective study. Multidrug-resi…
Bhat ZS, Rather MA, Ul Lah H, Hussain A, Maqbool M, et al.
…cidal agents that can shorten treatment duration and target drug resistance still remain a top priority in the discovery of anti-TB drugs. The objective of this study was to investigate the bactericidal potential of 3-cinnamoyl-4-hydroxy-6-methyl-2-pyrone (CHP) against drug-susce…
Heyckendorf J, Andres S, Köser CU, Olaru ID, Schön T, et al.
Rapid and accurate drug susceptibility testing (DST) is essential for the treatment of multi- and extensively drug-resistant tuberculosis (M/XDR-TB). We compared the utility of genotypic DST assays with phenotypic DST (pDST) using Bactec 960 MGIT or Löwenstein-Jensen to construct…
Chisompola NK, Streicher EM, Muchemwa CMK, Warren RM, Sampson SL
Background The burden of drug resistant tuberculosis in Africa is largely driven by the emergence and spread of multidrug resistant (MDR) and extensively drug resistant (XDR) Mycobacterium tuberculosis strains. MDR-TB is defined as resistance to isoniazid and rifampicin, while XD…
Yang J, Lu Y, Chen Y, Wang Y, Wang K
Objective This study aims to analyze the drug resistance spectrum, genetic diversity, and transmission dynamics to provide a basis for the prevention and control of drug-resistant (DR) tuberculosis (TB) epidemics. Methods This retrospective study is based on routine national drug…
Kateete DP, Kamulegeya R, Kigozi E, Katabazi FA, Lukoye D, et al.
…g cause of morbidity and mortality in developing countries. Drug resistance, a huge problem in this contagious disease, is driven by point mutations in the Mycobacterium tuberculosis genome however, their frequencies vary geographically and this affects applicability of molecular…
Jaber AAS, Ibrahim B
…nization (WHO) has reported that Yemen has a high burden of drug resistance and a worrying shortage of implemented diagnostic methods and drug treatment regimens. Therefore, in this study, we evaluated the risk factors associated with multidrug-resistant tuberculosis (MDR-TB) and…
Udhaya Kumar S, Saleem A, Thirumal Kumar D, Anu Preethi V, Younes S, et al.
Background and aim The persistence of extensively drug-resistant (XDR) strains of Mycobacterium tuberculosis (MTB) continue to pose a significant challenge to the treatment and control of tuberculosis infections worldwide. XDR-MTB strains exhibit resistance against first-line ant…
Abebaw Y, Abebe M, Tola HH, Mehammed Z, Getahun M, et al.
…acteriologically confirmed childhood Tuberculosis (PTB) and drug-resistant TB in Ethiopia is limited due to difficulties related to its diagnosis in this population. Therefore, this study aimed to assess bacteriologically confirmed childhood PTB Case Notification Rates (CNRs) and…
Al Mahrouqi S, Gadalla A, Al Azri S, Al-Hamidhi S, Al-Jardani A, et al.
…ulation. The present study examined the genetic profile and drug resistance-conferring mutations in Mycobacterium tuberculosis collected from Omanis and expatriates to recognise possible causes of disease transmission. Methods We examined M. tuberculosis cultured positive samples…
Ncha R, Variava E, Otwombe K, Kawonga M, Martinson NA
…SCC) and factors predictive of TTSCC in patients with multi-drug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) in the North-West Province. Methods A retrospective cohort study, abstracting patient demographic and clinical data, laboratory re…
Kamolwat P, Nateniyom S, Chaiprasert A, Disratthakit A, Mahasirimongkol S, et al.
Objective To assess the prevalence and risk factors of drug-resistant tuberculosis (TB), the fifth national anti-TB drug resistance survey was conducted in Thailand. Methods A cross-sectional study was conducted by stratified cluster sampling with probability proportional to size…
Ansarin K, Sahebi L
Background and objectives Drug-resistant tuberculosis (Tb) is a major public health issue across the world. Therefore, it is crucial to determine its pattern in different regions of the world. The aim of this study was to review the prevalence of drug resistant TB in the west and…
Oostvogels S, Ley SD, Heupink TH, Dippenaar A, Streicher EM, et al.
Extensively drug-resistant tuberculosis (XDR-TB), defined as resistance to at least isoniazid (INH), rifampicin (RIF), a fluoroquinolone (FQ) and a second-line injectable drug (SLID), is difficult to treat and poses a major threat to TB control. The transmission dynamics and dist…
Hu Y, Zheng X, Davies Forsman L, Ning Z, Chen C, et al.
Objectives Little is known about how additional second-line drug resistance emerges during multidrug-resistant tuberculosis (MDR-TB) treatment. The present study aimed to investigate the influence of microevolution, exogenous reinfection and mixed infection on second-line drug re…