Showing 1–25 of 52 documents
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Irina Kostyukova, Anna Vyazovaya, О. А. Пасечник, Igor Mokrousov
Background . The prevalence of multidrug-resistant tuberculosis poses a serious public health problem, hampering the success of tuberculosis control programs around the world. Aim : Evaluation of epidemiological manifestations of tuberculosis and molecular genetic characteristics…
Yang Che, Tianfeng He, Lin Lyu, Ping Guo-hua
…bjective To analyze the characteristics of second-line anti-tuberculosis (TB) drugs resistance and gene mutation of multidrug-resistant (MDR) Mycobacterium tuberculosis isolated in Ningbo. Methods In 1597 M. tuberculosis isolates collected in the first drug resistance survey in N…
O. A. Zhurilo, А. І. Barbova, L.B. Skokluk, O. V. Chernov
…le presents the experience of whole-genome sequencing of M. tuberculosis (MBT) strains. Materials and methods. 8 MBT isolates were tested. The strains were obtained from patients with newly detected pulmonary tuberculosis (NDPTB). Critical concentrations of anti-mycobacterial dru…
Jun Ma, Lin Fan, Hongcheng Liu, Wenting Li, Wenwen Sun
…global burden of Rifampicin Resistance ／Multidrug-Resistant tuberculosis (RR/MDR-TB) and low HIV incidence. Our aim was to assess the epidemiological and clinical characteristics of RR/MDR-extrapulmonary tuberculosis (EPTB) over the past five years in China to inform national TB …
Yu. D. Mikhailova, Marina Makarova, L. Yu. Krylova, S. G. Safonova, В. И. Литвинов
Due to the widespread drug resistance of M. tuberculosis (MTB), it is necessary to assess the possibility of using drugs with antimycobacterial activity previously used in other pathologies, e.g. clofazimine, in anti-tuberculosis chemotherapy regimens. The aim was to determine th…
M K Wijayanto, J Juniastuti, R Yudhawati, D Handayani
Abstract Rationale Tuberculosis (TB) remains a major global health challenge, affecting an estimated 10.8 million people worldwide. Indonesia ranks second globally in TB burden, with approximately one million cases annually. The prevalence of drug-resistant (DR) TB is also among …
DK Mumena, Geoffrey Kwenda, CW Ngugi, AK Nyerere
Background: Drug-Resistant Tuberculosis (DR-TB) is one of the major public health issues globally. Zambia is highly burdened by TB and multi-drug resistant TB. In this study, sputum samples obtained from the new and previously treated cases of TB were examined for drug-resistant …
О. А. Пасечник, Anna Vyazovaya, A. I. Bloch, Irina Yarusova, M. P. Tatarintseva, et al.
…nce. The spread of the epidemic and resistant Mycobacterium tuberculosis genotypes presents a serious threat to the implementation of the national tuberculosis control program in Russia. The study aimed to assess the trends in the development of the epidemic process of tuberculos…
Kamal Ahmadi, Nahid Madadi-Goli, M Masoumi, Mahshid Nasehi, Seyed Davar Siadat, et al.
Introduction: Tuberculosis, caused by Mycobacterium tuberculosis, is one of the most common infectious diseases worldwide. Epidemiological studies of M. tuberculosis drug resistance are critical for improving patient treatment approaches and controlling the spread of tuberculosis…
Richmond Ronald Gomes
…enitis is the most frequent extrapulmonary manifestation of tuberculosis infection. There are limited documents on multidrugresistant cervical tubercular lymphadenitis, but there is no evidence which may occur in TB endemic regions. Multidrug-resistant tuberculosis (MDR-TB) occur…
Ángel de Jesús Dzul-Beh, Karlina García‐Sosa, Andrés Humberto Uc‐Cachón, Jorge Bórquez, Luis Loyola, et al.
…th those reported in the literature. The anti-Mycobacterium tuberculosis activity of spathulenol was evaluated on MDR, pre-XDR, and XDR clinical isolates of M. tuberculosis, as well as on the reference susceptible strain H37Rv and its cytotoxic activity was evaluated on the Vero …
Anusmriti Pal, Tanka Acharya, Kamal Hamal, Nanda Acharya, Khadga Bikram Shah
Introduction: Tuberculosis is a global health concern, and its prevalence can vary widely from one region to another. Factors such as altitude, climate, population density, and healthcare infrastructure can all influence the dynamics of Tuberculosis in a particular area. This stu…
Marie José Bajani Kabedi, Steve Ahuka, Octavie Metila Lunguya, Jean Marie Kayembe, Hippolyte Nani Tuma Situakibanza, et al.
…Republic of the Congo, children are likely to be exposed to tuberculosis (TB) through close contact. Failure to diagnose can have devastating consequences. The objective of the present study was to determine the frequency of TB and the primary resistance of Mycobacterium tubercul…
А. В. Мордык, О. Г. Иванова, S. V. Sitnikova, V. I. Gusina, A. O. Ptukhin
…tment of newly diagnosed patients, including HIV-associated tuberculosis, with the mandatory inclusion of new anti-tuberculosis drugs in the treatment regimens of patients. drugs. Aim . To evaluate the efficacy and safety of bedaquiline in the complex treatment of patients with H…
Sofya Andreevskaya, Е. Е. Ларионова, Ekaterina A. Kiseleva, Л. Н. Черноусова, Atadzhan Ergeshov
…to evaluate changes in detection frequency of Mycobacterium tuberculosis of the main phylogenetic lines with various genetic determinants of resistance to rifampicin, isoniazid and fluoroquinolones in 1998–2003 and 2016–2021. Subjects and Methods. 965 mycobacterial cultures were …
С. Н. Жданова, Anna Vyazovaya, I. B. Lebedeva, V. V. Sinkov, И. Г. Кондратов, et al.
…acterized by a high prevalence of multidrug-resistant (MDR) tuberculosis (TB), including coinfection with HIV (HIV/TB). A previously unknown in Russia relationship between MDR and the Beijing Central Asian Outbreak (CAO) subtype has been discovered, which updates studies of Mycob…
Sarmat Z. Suleimanov, M. V. Sinitsyn, I. V. Golubenkov, L. E. Parolina, O. V. Lovаchevа, et al.
…to compare the spectrum of drug resistance of Mycobacterium tuberculosis obtained from respiratory and surgical specimens of pulmonary tuberculosis patients. Subjects and Methods . A non-randomized, continuous, single-center retrospective study was performed and included 102 pati…
Rajesh Kumar Yadav, Hari Prasad Kaphle, Dipendra Kumar Yadav, Suman Chandra Gurung, Elina Khatri, et al.
…ance among TB patients. The emergence of resistance to anti-tuberculosis drugs and particularly of multi-drug resistance (MDR), Pre-extensively drug resistance tuberculosis (Pre-XDR) and extensively drug resistance (XDR) tuberculosis have become a major public health problem in s…
Julia Bespyatykh
According to the WHO, tuberculosis morbidity remains high, despite a trend towards stabilization the situation remains extremely tense due to the distribution of resistant forms. The aim of the present study was to use omics approaches to detect changes in M. tuberculosis strains…
R Santosh
Introduction: Drug-resistant tuberculosis is a major public health problem throughout world. India accounts for 27% of global TB burden. More than half of TB patients in India are cared for in private sector. Usage of inappropriate TB diagnostic, treatment practices and lack of a…
R. V. Tarasov, Л. Н. Лепеха, S. S. Sаdovnikovа, E. V. Krаsnikovа, D. S. Barkova, et al.
…reatment of a patient with widespread destructive pulmonary tuberculosis with preXDR MBT against the background of severe bullous lung dystrophy after prolonged exogenous exposure to fine particles of coal dust in the anamnesis. Patient M., 42 years old, smoker, has been working …
Ulan Kozhamkulov, Asset Daniyarov, Ainur Akhmetova, Saule Rakhimova, Zhannur Abilova, et al.
In Kazakhstan, the total incidence rate of tuberculosis in 2021 was 74 cases per 100,000 population. The aim of this study was the characterization of drug-resistant (DR) <i>M. tuberculosis</i> (MTB) collected in Kazakhstan and to perform pilot whole genome sequencing for drug re…
Dana Auganova, Sabina Atavliyeva, Aygulya Akisheva, Anna Tsepke, Pavel Tarlykov
Tuberculosis remains a highly contagious infection, with an estimated annual transmission of about 10 million people globally, as reported in the latest Global Tuberculosis Report by the World Health Organization (WHO). The primary objective of this research is to determine the g…
С. Н. Жданова, И. Г. Кондратов, О. Б. Огарков
…aintains a high incidence rate of multidrug-resistant (MDR) tuberculosis (TB). Detection of MDR-associated Mycobacterium tuberculosis strains in Irkutsk region requires dynamic assessment of the TB pathogen population, taking into account the emergence of a new resistant variant …
S. V. Sklyuev, Е. М. Жукова, N. V. Stavitskaya
…cal case of a female patients with the continuous course of tuberculosis (more than 14 years). Despite the ongoing anti-tuberculosis therapy, the use of all possible surgical methods including valvular bronchial blocking, bacterial excretion persisted, fibrous cavernous tuberculo…