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World Health Organization, University of California, San Francisco
Helen Ayles, Professor
Tuberculosis (TB) has overtaken HIV as the leading infectious cause of death worldwide and requires a major policy shift for it to be controlled in line with the WHO Stop-TB goal to "end TB". However, how to control TB at population level in the context of HIV, is unknown. Some o…
Renu Kumari, Priyamvada Roy, Shalini Malhotra, Ulka Kamble, Nirmaljit Kaur
… counts in patients with both human immunodeficiency virus (HIV) and tuberculosis (TB) infections compared to HIV-positive patients without TB following six months of treatment with anti-tuberculosis therapy (ATT) and antiretroviral therapy (ART). This study aims to assess absolu…
Andrine
… in the biofluids of people suffering with IPF, COPD and TB/HIV co-morbidity. The test could both be used for diagnostics and disease progression tracking.<br/><br/>Methods: The study consists of three parts; a COPD study, IPF study and TB/HIV study. For the IPF study 32 urine sa…
Mohau S. Makatsa
… of the treatment is hampered by multidrug resistant TB and HIV infection. There is an urgent need for an effective TB vaccine to prevent ongoing transmission. The development of a new and efficacious TB vaccine will likely be dependent on our understanding of protective immunity…
Amita Gupta, MD
…ases globally, with approximately 86,000 among persons with HIV (PWH). Unhealthy alcohol use can worsen the health of people who have Tuberculosis (TB), HIV and people who have both TB and HIV. Behavioral interventions that 1) target alcohol use and 2) are integrated into TB and …
Ian Sanne, Yara Voss De Lima, Antonia Barnard, Colin Menezes, Liesl Page‐Shipp, et al.
ObjectiveTo assess the outcomes of linkage to TB and HIV care and identify risk factors for poor referral outcomes.DesignCohort study of TB patients diagnosed at an urban hospital.MethodsLinkage to care was determined by review of clinic files, national death register, and teleph…
Anne Detjen, Shaffiq Essajee, Malgorzata Grzemska, Ben J. Marais
…novel partnerships for child health and development.•TB and HIV partners need to align better and jointly formulate strategies to scale up pediatric TB and HIV in an integrated MNCH and PHC context.•Integrated, family-centered approaches, implemented at the community and primary …
Kogieleum Naidoo, MBChB
…uth Africa, which is, to develop and test optimal models of HIV-TB service delivery that will enhance retention, adherence and coverage of HIV-TB co-infected patients. HIV and TB are highest in sub-Saharan Africa, a region with limited health budgets, infrastructure, human resour…
Lusiana R Idrus, Master
…tionale: The co-infection of human immunodeficiency virus (HIV) and tuberculosis (TB) diseases presents further problems to patient's adherence due to high pill burden and adverse effects in the drug combination therapy. This situation is also a risk of the increase of multi-dru…
Olivier Marcy, MD, PhD, Maryline Bonnet, MD, PhD, Eric Wobudeya, MD, PhD
TB-Speed HIV is a prospective multicentre management study evaluating the safety and feasibility of the recently proposed PAANTHER TB treatment decision algorithm for HIV-infected children with presumptive TB. It will be conducted in four countries with high and very high TB (Tub…
Margherita Bracchi, Clare van Halsema, Frank A. Post, Funmi Awosusi, Alison Barbour, et al.
…helped transform the management of TB in people living with HIV. The overall purpose of these guidelines is to help physicians manage adults with tuberculosis (TB)/human immunodeficiency virus (HIV) co-infection. Recommendations for the treatment of TB in HIV-positive adults are …
Waleed MD Gamal Elddin Khaleel, Ass. Prof.
People Living with HIV (PLHIV) are prone to several opportunistic infections depending on the degree of immunosuppression as well as infections prevalent in their geographic area/country. These include a wide variety of mycobacterial diseases, fungal infections, bacterial pneumon…
Yalemzewod Assefa Gelaw
…er of the global burden of TB. This is associated with high HIV-prevalence, low socio-demographic development, and poor living and working conditions. Identification of high-risk populations and locations within countries with a high burden of TB has the potential to improve the …
VINA LUSIANA
…an Immunode_ciency Virus/Acquired Immuno-deciency Syndrome (HIV/AIDS) are major burden of infectious diseases in developing countries. TB and HIV infection have the effect of deeply on assault the immune system, since they can afford to weaken host immune respone through a mechan…
Leslie A. Enane, Adam Leonard, Lameck Diero, Olivier Marcy, Marcel Yotebieng
…d the most common opportunistic infection among people with HIV, imposes a profound burden on adolescents and young adults (AYA, ages 10–24 years) [1]. Although preventable and curable, TB remains a leading cause of death for AYA in endemic settings, the predominant cause of morb…
Mihir P. Rupani, Sheetal Vyas
…ctors of catastrophic costs due to TB among co-prevalent TB-HIV and TB-diabetes patients. Methods: We conducted a cross-sectional study among 234 patients co-affected with TB-HIV and 304 patients with TB-diabetes co-prevalence in the Bhavnagar region (western part of India). TB c…
Mihir P. Rupani, Sheetal Vyas
…ssaving employed and enablers perceived by patients with TB-HIV, patients with TB-diabetes, and program managers of TB. Methods: We conducted qualitative in-depth interviews among eight TB-HIV patients, eight TB-diabetes patients, and seventeen program managers of TB in the Bhavn…
Elizabeth Corbett, MD, David Dowdy, MD. PhD, Lawrence Moulton, PhD
… algorithms for TB case detection on Tuberculosis (TB)- and HIV-related outcomes; (2) to compare the impact of using the routine screening and GeneXpert algorithms for exclusion of TB prior to initiation of IPT and ART on TB- and HIV-related outcomes; and (3) to assess the relati…
Per Bjorkman, M.D., Ph.D.
Background: Tuberculosis (TB) and HIV are leading causes of disease and death in Subsaharan Africa. Antiretroviral therapy (ART) dramatically improves prognosis in HIV infection, but TB is still a common complication in HIV-infected subjects. Management of TB-HIV co-infection is …
John C. Mgogwe, Jaffu Otheniel Chilongola
…nt tuberculosis (MDR-TB) with human immunodeficiency virus (HIV) immunologic state which is marked by chemokine and cytokine distortion is indicated by boosting the defense stimulation to a patient. The effect of coexisting infections on the MDR-TB patient with HIV is still not f…
Surendra K Sharma, M.D., Ph.D
HIV induced altered representation and function of regulatory T cell subsets (NKT and Treg cells) impair the protective T cell response against M.tuberculosis and disrupts LTBI, thus facilitates faster progression and development of severe forms of clinical TB in HIV-TB co-infect…
Institut National de la Santé Et de la Recherche Médicale, France
…tional PK study of anti-TB treatment nested in the TB-Speed HIV and TB-Speed SAM studies aiming at assessing the impact of malnutrition on PK of rifampicin, isoniazid, pyrazinamide, and ethambutol in TB-HIV co-infected children in Uganda and Zambia. Tuberculosis can worsen malnu…
Vannesa Yue May Teng, Yan Ting Chua, Eunice En Ni Lai, Shilpa Mukherjee, Jessica Michaels, et al.
…TRACT Objectives Tuberculosis (TB) is a common infection in HIV patients. Our study aims to determine the prevalence and characteristics of HIV-TB co-infected patients in Singapore, a high-income, intermediate TB-burden country. Methods Retrospective data of 11-years was obtained…
Taya Rizki Arini Harahap, Tambar Kembaren, Endang Sembiring
…ulmonary TB. Aim: To assess difference in survival rates of HIV patients with pulmonary TB and extra pulmonary TB. Results: Based on Fisher's Exact test, it was found that there was no statistical difference survival rates of HIV patients with pulmonary TB and extra-pulmonary TB …