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Maral Budak, Joseph M. Cicchese, Pauline Maiello, H. Jacob Borish, Alexander G. White, et al.
…ng more effective and more patient-friendly antibiotic drug regimens to increase patient compliance and decrease emergence of resistant TB. Moxifloxacin is one promising antibiotic that may improve the current standard regimen by shortening treatment time. Clinical trials and in …
Karnappa Bhangari, Basavaraj Sangolli, H. N. Jagadeesha
A comparative assessment of daily dosage regimen versus intermittent treatment regimen of tuberculosis at the RNTCP centres in Chitradurga district - IJIRM- Print ISSN No: - 2581-4214 Online ISSN No:- 2581-4222 Article DOI No:- 10.18231/j.ijirm.2020.037, IP Indian Journal of Immu…
Moti Chapagain, Tawanda Gumbo, Scott K. Heysell, Shashikant Srivastava
…in and ethambutol. Unfortunately, therapy duration for both regimens lasts for years. In this study, we administered tedizolid, minocycline, clarithromycin, and rifapentine as monotherapy as well as novel combinations in the intracellular hollow-fiber model system of M. kansasii …
Alex Nachman, Zain Chagla
CLINICAL IMPACT RATINGS: GIM/FP/GP: [Formula: see text] Infectious Disease: [Formula: see text] Pulmonology: [Formula: see text].
Andi Ibnu, Hajar Azis, Ngakan Putu, Persama Putra, Teguh Rahayu Sartono, et al.
however, there was persistence of A repeat chest scan showed interval development of cavity formation with no significant change in size of the mass lesion. The patient was referred to thoracic surgery and underwent right lower lobectomy. Intra-operative findings include a well-c…
Kelly Dooley, MD, Daniel W Fitzgerald, MD, Ekaterina V Kurbatova, MD, PhD, MPH, Wendy Carr, PhD
…se of this study is to determine whether one or two 17-week regimens of tuberculosis treatment bedaquiline (B or BDQ), moxifloxacin (M), pyrazinamide (Z)-- (BMZ) plus either Rifabutin (Rb) or Delamanid (D or DLM) are as effective as a standard six-month regimen for treatment of p…
Masayuki Ikeda, Hiroki Matsui, Yasuhiro Morimoto, Norihiko Kubota, Tatsuya Nagai, et al.
…%) patients received clarithromycin- and azithromycin-based regimens, respectively. The aORs for initial regimen modification were as follows; age 1.05 (95% CI; 1.01-1.10), women 0.77 (95% CI; 0.34-1.74), body mass index 1.06 (95% CI; 0.96-1.18), smear-positive status 0.85 (95% C…
Narendran Gopalan, DNB (Chest), Soumya Swaminathan, MD
…dividuals treated for TB treated with standard intermittent regimens. The study would generate data on the efficacy of daily and thrice weekly regimen of ATT in pulmonary TB patients with HIV in the presence of highly active antiretroviral therapy (HAART). Not many trials have co…
Hisayuki Shuto, Kosaku Komiya, Akihiko Goto, Takamasa Kan, Kokoro Honjo, et al.
…ficacy and safety of fluoroquinolone-containing combination regimens as an alternative remain uncertain. This study aimed to compare the efficacy and safety of fluoroquinolone-containing regimens with those of the standard regimens for treating pulmonary MAC disease. METHODS: We …
Lyndon P. James, Fayette Klaassen, Sedona Sweeney, Jennifer Furin, Molly F. Franke, et al.
…ging evidence suggests that shortened, simplified treatment regimens for rifampicin-resistant tuberculosis (RR-TB) can achieve comparable end-of-treatment outcomes to longer regimens. We compared a 6-month regimen containing bedaquiline, pretomanid, linezolid, and moxifloxacin (B…
Srikant Kashinath Malegaonkar, Valliappan Muthu, Ashutosh N. Aggarwal, Digambar Behera, Ritesh Agarwal
… article by Velayutham and colleagues, reporting on shorter regimens for newly diagnosed pulmonary tuberculosis [1]. Shortening the duration of tuberculosis treatment is an unmet research need [2]. In this regard, the trial by Velayutham et al. is commendable. Nevertheless, it ha…
University College, London
…: The objective of the Phase 2B stage is to identify novel regimens of 16 weeks' duration with acceptable safety profile and the greatest potential, based on assessment of quantitative sputum liquid culture and treatment failure/relapse, to progress to investigation of optimal t…
Ju Mi Lee, Jiyun Park, Sang‐Won Choi, Byung Woo Jhun, Su‐Young Kim, et al.
…se (MAC-PD) remain unsatisfactory. Thus, improved treatment regimens for MAC-PD are required. Clofazimine has recently been revisited as an effective drug against mycobacterial infection. We performed a comparison between the standard regimen and an alternative regimen (replacing…
Dr. Banurekha MBBS., MPH
The 4-month daily regimen containing moxifloxacin (2HRZEM 7 / 2HRM7) of ICMR-NIRT was studied in 321 sputum positive pulmonary TB patients in a randomised clinical trial. Of the 321, there were 96% with sputum smear grading of 2+/3+ and 80% with \>2 zone involvement in the chest …
Joseph M. Cicchese
… antibiotic treatment. Importantly, we find that changes to regimens provide greater improvements in granuloma sterilization times for these individuals. We also present a new pharmacodynamic model that incorporates the synergistic and antagonistic interactions associated with co…
J. A. M. Raaijmakers, Mike Marvin Ruth, Jodie A. Schildkraut, Erik van den Hombergh, Rob E. Aarnoutse, et al.
…ls infected with M. avium ATCC 700898 were exposed to these regimens for 21 d. PK profiles were determined at d 0 and d 21. The pharmacodynamic effect was measured by determining bacterial densities at d 0, 3, 7, 14 and 21 for intra- and extracellular fractions. Emergence of macr…
J van Ingen, F -Q ter Bruggen, A Lemson, W Hoefsloot
…cure in MAC-PD patients treated with clofazimine-containing regimens at a Dutch tertiary care center. Methods Single-centre retrospective cohort study of adults with macrolide-susceptible MAC-PD who initiated treatment with clofazimine as part of either a standard ethambutol-macr…
Hélène E. Aschmann, Allan Musinguzi, Jillian L. Kadota, Catherine Namale, Juliet Kakeeto, et al.
…f offered different tuberculosis preventive treatment (TPT) regimens, and under which conditions they would accept treatment. Actionable evidence regarding preference for TPT is needed to inform policy and the development of novel TPT regimens. Methods: Adults engaged in care at …
J. A. M. Raaijmakers, Sandra Salillas, Rob E. Aarnoutse, Elin M. Svensson, Lindsey te Brake, et al.
…macodynamics were monitored throughout the experiment. Both regimens led to sustained bacterial killing (both intracellular and extracellular) throughout the experiment. No difference in kill rate was observed between the two therapies. The extracellular kill rate for the 3-drug …
Dhondiba Haribhau Bhise
…tum smear conversion in daily versus intermittent treatment regimens in diagnosed cases of new sputum smear-positive pulmonary tuberculosis patients. METHODS This retrospective observational study was carried out in the Department of Respiratory medicine and nodal drug resistance…
Hua Li, Tong Li, Jun Wang, Qingtao Liang, Yun Zhang, et al.
BACKGROUND: ) lung disease remains far from satisfying. An effective regimen is needed to solve the problem. METHODS: lung disease who received antibiotics regimen at Beijing Chest Hospital Affiliated to Capital Medical University between July 1, 2010, and February 1, 2018. Patie…
Vijay Kumar, Upinder Kaur, Mohit Bhatia, Jaya Mishra
<bold>Introduction:</bold> Real-world evidence on oral regimens for drug-resistant tuberculosis (DR-TB) is scarce. <bold>Aims and objectives:</bold> To assess culture conversion at 6 months and adverse events (AEs) with oral regimens of DR-TB. <bold>Methods:</bold> A prospective …
Wenhong Zhang, Dr.
This study is a randomized controlled trial among asymptomatic tuberculosis individuals aiming to assess whether the standard treatment duration can be shortened to 17 weeks without increasing the types or doses of anti-tuberculosis medications or 13 weeks with the high-dose rifa…
Alexander Berg, James Clary, Debra Hanna, Eric L. Nuermberger, Anne J. Lenaerts, et al.
…necessitating the development of new and improved treatment regimens. Non-clinical evaluation of candidate drug combinations via the relapsing mouse model (RMM) is an important step in regimen development, through which candidate regimens that provide the greatest decrease in pro…
Malaisamy Muniyandi, Nagarajan Karikalan, Banurekha Velayutham, Kavitha Rajsekar, Chandrasekaran Padmapriyadarsini
Abstract Globally efforts are underway to shorten the existing 6-month tuberculosis (TB) treatment regimen for drug-sensitive patients, which would be equally effective and safe. At present, there is a lack of evidence on the cost implications of a shorter 4-month TB regimen in I…