Showing 1–25 of 200 documents
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Dick Menzies, MD
…fe; 2. Tuberculosis Preventive Treatment (TPT) with shorter regimens are superior with respect to acceptance, completion, and costs; 3. 4 months of Rifampin 10mg/kg (4R10) is the safest regimen, but is completed by \<80% of patients; 4. The safety of 2 months of Rifampin 20mg/kg …
Qiaoling Ruan, Jingyu Zhou, Shufeng Weng, Lingyun Shao, Wenhong Zhang
…ts. The World Health Organization recommends LTBI treatment regimens, including 6 or 9 months of once-daily isoniazid (INH, H), 4 months of once-daily rifampin (RIF, R), 3 months of once-weekly rifapentine (RPT, P) plus INH (3HP), 3 months of once-daily RIF plus INH, or 1 month o…
Jann-Yuan Wang, MD, PhD
…1.00-1.02\], p = 0.218). The 3HP regimen is among the four regimens for LTBI that is recommended by the WHO and is also probably the most promising regimen because of its convenience, with only 12 doses requried. With its effectiveness well established, the major remaining conce…
Aliya Moreira, Dana Hassneiah, Susan E. Beekmann, Philip M. Polgreen, Maunank Shah, et al.
…e 2020, CDC guidance has preferentially recommended shorter regimens for tuberculosis (TB) infection and since 2022, recommendations include 6-month regimens for drug-resistant (DR-TB) disease containing bedaquiline, linezolid, and pretomanid (BPaL) and a 4-month regimen for drug…
Ilangovan Ilavarasan, Vidhyanathan Ariharanathan, Chandrasekaran Sabitha Devi
…CI). Conclusion: The weekly HP regimen is superior to other regimens in reducing the incidence of TB. Additionally, the duration of the HP regimen is shorter compared to the commonly advised nine-month Isoniazid regimen. Compared with the daily dosage of Isoniazid, the weekly HP …
Chin-Chung Shu
…emains unclear. Currently, three-month rifamycin-containing regimens, such as weekly rifapentine and isoniazid (3HP) or daily rifampicin and isoniazid (3HP), are common because its non-inferiority to nine-month of daily isoniazid (9H) and high completion rate by its short course …
Soedarsono Soedarsono
… well as changes in the grouping of medicines used in DR-TB regimens in longer/individual regimens. Bedaquiline, delamanid, pretomanid, and sutezolid are new drugs which have been studied for their uses as anti-TB drugs (ATD). Bedaquilin and delamanid, which have passed phase 3 t…
Gavin Koh
BACKGROUND: Rifapentine-based regimens have potent antimycobacterial activity that may allow for a shorter course in patients with drug-susceptible pulmonary tuberculosis.METHODS: In an open-label, phase 3, randomized, controlled trial involving persons with newly diagnosed pulmo…
Anthony Harries, Kudakwashe C Takarinda
BACKGROUND: Rifapentine-based regimens have potent antimycobacterial activity that may allow for a shorter course in patients with drug-susceptible pulmonary tuberculosis.METHODS: In an open-label, phase 3, randomized, controlled trial involving persons with newly diagnosed pulmo…
Jann-Yuan Wang, Ph.D.
…e very helpful for policy making in public health. Several regimens have been used in treating LTBI, including 9-month isoniazid, 4-month rifampin, 2-month rifampin plus pyrazinamide, and 3-month isoniazid plus rifampin. Among the 4 regimens, 2-month rifampin plus pyrazinamide h…
Jacques Simkins, Yoichiro Natori, Shweta Anjan, Giselle Guerra, Rodrigo Vianna
…hs is more likely to cause liver toxicity compared to other regimens and its rate of completion can be lower than 50%. As of result of this, there has been a shift in the treatment of LTBI. The following short-regimens: 3 months of weekly isoniazid plus rifapentine, 4 months of d…
Hannah Tan, Arlene Dy-Co
…currently available Latent Tuberculosis Infection treatment regimens, 6 months isoniazid (6H) and 3 months isoniazid plus rifampicin (3HR), based on the 2020 Department of Health National Tuberculosis Control Program Tuberculosis Preventive Treatment guidelines for children. Meth…
Julian Surey, Helen R. Stagg, Thomas A Yates, Marc Lipman, Peter J White, et al.
…(LTBI) to prevent future cases. Promising trials of shorter regimens have shown them to be effective as preventative TB treatment, however there is a paucity of data on self-administered treatment completion rates. This pilot trial assessed treatment completion, adherence, safety…
Campos-Outcalt
… for Disease Control and Prevention detail 3 shorter-course regimens that take no more than 4 months. In this month’s audiocast, Dr. Campos-Outcalt describes the regimens and who should be screened for TB.
Meenu Singh, Kulbir Kaur, Anil Chauhan, Manvi Singh, HarnoorKaur Sra, et al.
…e efficacy and safety of isoniazid (INH) versus alternative regimens for preventing active tuberculosis in children. Methods: A detailed analysis of the randomized controlled trials, methodology, interventions, and outcomes was done. Electronic searching was done through differen…
Huashan Hospital
… been established. The integration of ultra-short treatment regimens with active screening holds the potential to provide a comprehensive and effective strategy for tuberculosis prevention and control in school environments, which may help reform the national tuberculosis policy …
Jann‐Yuan Wang, Hung‐Ling Huang, Chih‐Hsin Lee
<bold>Background:</bold> The 3HP regimen—weekly rifapentine plus isoniazid for 12 doses—improves the completion rate of latent tuberculosis infection (LTBI) treatment, but flu-like symptoms are common. The new 1HP regimen—daily rifapentine plus isoniazid for 28 days—has low toxic…
Miguel Santín
…h rifapentine (P) + isoniazid (H) weekly for 12 weeks (3HP) regimens is better than with a 3-month (3HR) regimen for treatment of latent tuberculosis (TB) infection (LTBI) in patients with end stage kidney disease. Methods Design: Multicenter, prospective, parallel-group, open-l…
World Health Organization
… support the generation of high-quality evidence on new TPT regimens, addressing persistent limitations in available data, including low certainty of evidence, incomplete reporting and insufficient consideration of key decision-making criteria. Developed as a complement to WHO t…
Paola Castellotti, Maurizio Ferrarese, Matteo Saporiti, Daniela Campisi, Giorgio Besozzi, et al.
…in contacts of INH-resistant cases, while RIF containing PT regimens progressively became a prevalent choice from 2011 on. Of the 18961 with complete records, 82,7% received isoniazid (INH) for 6 months, 15.4% combined rifampicin and isoniazid ( RIF+INH) for 3 months, and 1.9% RI…
Christopher Pease
Background: The incidence of tuberculosis (TB) among Inuit is over 400 times that of Canadian-born non-indigenous people. To address this, more patients will need to complete preventative treatment. Methods: First, data were extracted retrospectively for all patients with a tuber…
Zareen Zaka, Thomas Satre
University of Minnesota, St. Cloud Hospital FMR, St. Cloud, MN The authors declare no conflicts of interest.
Erick Manuel Delgado Moya, Diego Samuel Rodrigues
<p>In this paper, we proposed a mathematical model for the study of tuberculosis treatment with latent treatment, taking into account the 3HP and 1HP. The model is constructed using a fractional order derivative in the Caputo sense to take advantage of the memory effect. Th…
Pei-Chun Chan, Pin-Hui Lee, Min-Ju Lu, You-Chieh Huang, Teng-Yi Feng, et al.
<b>Our experience has shown that with proper support and medical care under programmatic conditions, it is feasible to achieve a high completion rate of 3HP even among the elderly</b>http://ow.ly/o3ED30nQfRx
Aleksei O. Barnaulov, Irina A. Rasmagina, Marina N. Kondakova, Vitaliy V. Khabirov, Elena B. Lelekova
Background. Biological agents, especially anti-tumor necrosis factor blocking agents, frequently are used to treat autoimmune inflammatory rheumatic diseases. Due to their negative impact on immune system and high risk of reactivation of latent tuberculosis infection all the pati…