Showing 1–25 of 144 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Daniela Russo
Despite its ancient origins, tuberculosis (TB) remains a major public health problem. In the pediatric population, the prevention and diagnosis of TB is considered a major challenge. For this reason, this scoping review will be conducted in order to systematically map the researc…
Roxana Mansour Ghanaie, Abdollah Karimi, Leila Azimi, Seddon James, Mahshid Nasehi, et al.
… Although the World Health Organization has recommended the diagnosis and prophylactic treatment of latent tuberculous infection (LTBI) in child household contacts of tuberculosis (TB) cases, the national programs in high-burden TB regions rarely implement adequate screening of t…
Özlem Tezol
Objectives: Pediatric tuberculosis is a major public health problem. Malnutrition characterized with wasting is prevalent among pediatric tuberculosis patients. We aimed to review pediatric tuberculosis cases by considering their nutrition manifestations. Materials and Methods: T…
Tulane University
Pediatric tuberculosis (TB) continues to pose diagnostic challenges in low- and middle-income countries with high rates of TB disease, due to the well-described impact of paucibacillary disease in children, and current TB culture and polymerase-chain reaction tests are of limited…
Krunal Patel, Kinjal Patel, Pooja Gandhi, Bhavini Rathwa, Dipak M. Nakum
Introduction: Tuberculosis is a chronic infectious disease caused by predominantly Mycobacterium tubercle bacilli. Pediatric tuberculosis is among the top 10 causes of death in children. India accounts for one fourth of the global tuberculosis burden, standing one among the thirt…
Francesca Montagnani, PhD, MD
…T, Cellestis Limited, Carnegie, Victoria, Australia) in the diagnosis of tuberculosis (TB - active or latent) in pediatric subjects (0 and 17 year)s recently exposed to infection (indicated as "contacts") or with clinical suspicion of active TB, and to compare the results obtaine…
Wiwiek Setiowulan, redi rulandani, Helmy Rachman
Pediatric drug reaction with eosinophilia and systemic symptoms (DRESS) is a life-threatening uncommon disease that can be difficult to diagnose. We present a case of a 10-year old girl with ten days of high fever during her fifth week of ATT (consisting of isoniazid, rifampicin,…
Patricia Comella-del-Barrio, José Luis Izquierdo-García, Ramón Campos‐Olivas, Clara M. Santiveri, Jesús Ruı́z-Cabello, et al.
Children’s paucibacillary tuberculosis (TB) and their difficulty to expectorate leads to low diagnostic sensitivity. Most TB in children are diagnosed by clinical scoring systems limited by the TB clinical presentation. Pediatric TB diagnosis research should be focused on new bio…
Muhammad Abbud Widitaputra, Retno Asih Setyoningrum, Agus Harianto
Tuberculosis, caused by Mycobacterium tuberculosis, is transmitted through the release of bacteria into the air via respiratory activities, such as breathing and coughing. Untreated latent tuberculosis can act as a reservoir for future infections. Remote regions like Masalembu en…
Stefani Candra Firmanti, Rina Triasih, Tri Wibawa, Sofia Mubarika Haryana
BACKGROUND: The diagnosis of tuberculosis (TB) in children is challenging by the absence of a practical gold standard. Interferon (IFN)-ginducible protein 10 (IP-10) is a chemokine that may serve as the leading candidate marker in child TB diagnosis. The aim of this study is to a…
Meyer Children's Hospital IRCCS
…s were reported in 2020, of which 1 million occurred in the pediatric population. However, epidemiological data available on tuberculosis (TB) in pediatric age are extremely limited due to diagnostic challenges in this patient category. Furthermore, children are almost never incl…
E. P. Еremenko, Е. А. Бородулина, I. A. Sergeeva, D.А. Kudlаy, B. E. Borodulin
…ests (Mantoux test with 2 TU PPD-L and diaskintest) for the diagnosis of tuberculosis infection, in vitro tests are used. One of these tests is T-SPOT.TB being more widely used in recent years. The objective : to evaluate the effectiveness of T-SPOT.TB test for early detection of…
Anastasia Y. Starshinova, И. Ф. Довгалюк, Ulia Ovchinnikova, Анна Старшинова, P. K. Yаblonskiy
<b>Introduction:</b> Early diagnosis of TB infection in children is complicated due to poor clinical signs, minor X-ray abnormalities, and absence of bacterial excression. Potential of Mantuox 2 TE test in population with common BCG vaccination is limited due to its low diagnosti…
Deepak V. Sawant, Shivaji H. Pawar
Tuberculosis (TB) is a transmissible disease caused by Mycobacterium tuberculosis. TB infection affects mainly upper respiratory organs such as the lungs, so-called pulmonary TB. They can also affect multiple organs like bones, joints, skin, and genital organs, etc., are extrapul…
Hongmei Chen, Changxing Shen, Dan Li
…Introduction: Children exhibit heightened susceptibility to tuberculosis (TB), a disease caused by Mycobacterium tuberculosis (MTB) infection. Among the interferon-gamma release assays (IGRAs) recommended by the World Health Organization (WHO) for MTB infection screening is the n…
Jeffrey I. Campbell, Yamini Adusumelli, Mary Tabatneck, Susan N. Sherman, Gabriella S Lamb, et al.
…ackground Understanding barriers and facilitators to latent tuberculosis infection (LTBI) diagnosis and care is needed to successfully treat children/adolescents with LTBI in the US. We explored physicians’ perspectives on pediatric LTBI diagnosis and care, and strategies to impr…
Layla Silveira, Williane Fernandes, A Monteiro, Livia Valle, Amanda Soares, et al.
BACKGROUND: Perinatal Tuberculosis (TB) is a rare disease, transmitted during pregnancy or postnatal. Its clinical presentation is similar to congenital infections and neonatal sepsis, thus, remains underestimated and underdiagnosed. CASE PRESENTATION: A 34 week female child, bor…
Jeffrey I. Campbell, Thomas J. Sandora, Jessica E. Haberer
… estimated 1 million children develop and ~200,000 die from tuberculosis (TB). The WHO has named identification and treatment of latent tuberculosis infection (LTBI) one of the cornerstones of efforts to eliminate TB by 2030. Identification and treatment of pediatric LTBI require…
Sofia Kostoudi, Robert Hammond
ABSTRACT Background Tuberculosis (TB) is the second leading infectious killer after COVID-19 and the 13 th leading cause of death worldwide. Latent tuberculosis (LTBI) has become a major pool of potential active tuberculosis cases and is propelling the TB global health burden fur…
Beuy Joob, Viroj Wiwanitkit
… “Performance of Interferon-Gamma Release Assay (IGRA)s for Tuberculosis Screening in Pediatric Inflammatory Bowel Disease” with great interest (1). Stevens et al noted that “IGRA's are a useful tool to screen for LTBI, both prior to anti-TNF therapy and during treatment (1).” Th…
M. E. Lozovskaya, Yu. А. Yarovaya, E. В. Vasilieva, L. N. Khamchieva, Anna Mosina, et al.
…nation of hereditary pathology – Gaucher disease and latent tuberculosis infection in an 8-y ea r-o ld child. The child was examined for tuberculosis due to disseminated small foci and calcination in the lung tissue detected by chest computed tomography. The particular parameter …
Vaiva Šiuparytė, Justina Žvikevičiūtė, Vaida Kudirkienė
Introduction Tuberculosis (TB) in children receiving immunosupresants, such as tumor necrosis factor α inhibitors (TNFis), is rare; however, these patients are at an increased risk for severe TB disease and significant long-term morbidity [1]. We present a case of disseminated TB…
James P. Stevens, Cortney R. Ballengee, Raguraj Chandradevan, Amelia B. Thompson, Bess T. Schoen, et al.
…ts negative predictive value, moreover, was 99.9%. Multiple pediatric studies with a larger number of patients positive for tuberculosis have demonstrated IGRAs to have a higher sensitivity than TST (1,2). TSTs suffer from the subjectivity of the individual interpreting the skin …
A A Amaral Ibiapina Parente, L De Melo Lima, R Baroni Aurílio, A Rodrigues Fonseca, F Sztajnbok, et al.
…ground:</b> Patients with rheumatic diseases have more tuberculosis (TB) but are few studies about TB and latent tuberculosis (LTBI) in pediatric subjects with those diseases. Objectives:Describe subjects with rheumatic diseases and diagnosis of TB or LTBI in a pediatric&nbs…
Ayling Sanjaya
Background: Pediatric tuberculosis (TB) is a major health problem in the world and Indonesia. The difficulty of diagnosis is a major factor in eradicating TB in children. Active and latent tuberculosis in children often shows no symptoms so it is difficult to diagnose and affect …