Showing 1–25 of 46 documents
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Sahjid Mukhida, Chanda Vyawahare
…ng are not in common people regarding various categories of drug-resistant TB (DRTB).[2] They don’t have awareness and differentiation about mono-resistant, multidrug-resistant (MDR), poly-drug-resistant (pDR), pre-extensive drug resistance (Pre-XDR), extensive drug resistance (X…
DK Mumena, Geoffrey Kwenda, CW Ngugi, AK Nyerere
Background: Drug-Resistant Tuberculosis (DR-TB) is one of the major public health issues globally. Zambia is highly burdened by TB and multi-drug resistant TB. In this study, sputum samples obtained from the new and previously treated cases of TB were examined for drug-resistant …
R Santosh
Introduction: Drug-resistant tuberculosis is a major public health problem throughout world. India accounts for 27% of global TB burden. More than half of TB patients in India are cared for in private sector. Usage of inappropriate TB diagnostic, treatment practices and lack of a…
Yang Che, Tianfeng He, Lin Lyu, Ping Guo-hua
…e the characteristics of second-line anti-tuberculosis (TB) drugs resistance and gene mutation of multidrug-resistant (MDR) Mycobacterium tuberculosis isolated in Ningbo. Methods In 1597 M. tuberculosis isolates collected in the first drug resistance survey in Ningbo between 2018…
Yu. D. Mikhailova, Marina Makarova, L. Yu. Krylova, S. G. Safonova, В. И. Литвинов
Due to the widespread drug resistance of M. tuberculosis (MTB), it is necessary to assess the possibility of using drugs with antimycobacterial activity previously used in other pathologies, e.g. clofazimine, in anti-tuberculosis chemotherapy regimens. The aim was to determine th…
Beauty Makamure, Dan Ward, Tsitsi Bandason, Martha Chipinduro, Collins Timire, et al.
Background: Drug-resistant tuberculosis (DR-TB) is a major public health issue in Zimbabwe. Whole-genome-sequencing (WGS) is recommended for studying drug-resistant mutations, lineages, prevalence, and transmission patterns. However, there are limited data on drug-resistant confe…
Ulan Kozhamkulov, Asset Daniyarov, Ainur Akhmetova, Saule Rakhimova, Zhannur Abilova, et al.
…pulation. The aim of this study was the characterization of drug-resistant (DR) <i>M. tuberculosis</i> (MTB) collected in Kazakhstan and to perform pilot whole genome sequencing for drug resistance detection. Drug susceptibility testing to first/second-line anti-TB drugs was done…
Sarmat Z. Suleimanov, M. V. Sinitsyn, I. V. Golubenkov, L. E. Parolina, O. V. Lovаchevа, et al.
The objective: to compare the spectrum of drug resistance of Mycobacterium tuberculosis obtained from respiratory and surgical specimens of pulmonary tuberculosis patients. Subjects and Methods . A non-randomized, continuous, single-center retrospective study was performed and in…
Rajesh Kumar Yadav, Hari Prasad Kaphle, Dipendra Kumar Yadav, Suman Chandra Gurung, Elina Khatri, et al.
… is a major cause of treatment failure and the emergence of drug resistance among TB patients. The emergence of resistance to anti-tuberculosis drugs and particularly of multi-drug resistance (MDR), Pre-extensively drug resistance tuberculosis (Pre-XDR) and extensively drug resis…
…esearch and testing of Mycobacterium tuberculosis (MBT) for drug susceptibility in the Russian Federation is carried out with uneven qual-ity, which distorts the idea of primary drug resistance (DR). Aim. To study the primary DR of MBT to the main combinations of anti-TB drugs fo…
Tatiana Umpeleva, Kseniya Belousova, Ludmila Golubeva, Nataliya I. Eremeeva, Diana Vakhrusheva
…s patients in Russia. It has stronger association with multidrug resistance and possesses unique pathogenic properties. <b>Objectives:</b> To identify the spectrum of drug resistance mutations of MTB Beijing B0/W148 isolated from patient living in Ural Federal District of Russia.…
M K Wijayanto, J Juniastuti, R Yudhawati, D Handayani
…approximately one million cases annually. The prevalence of drug-resistant (DR) TB is also among the highest, with about 7.4% of cases classified as rifampicin-resistant (RR) or multidrug-resistant (MDR) TB. Indonesia is likewise a high-burden country for TB-HIV coinfection. Nati…
Dana Auganova, Sabina Atavliyeva, Aygulya Akisheva, Anna Tsepke, Pavel Tarlykov
… research is to determine the geographical distribution and drug resistance profiles of Mycobacterium tuberculosis lineage 2, which is predominant in Kazakhstan. A total of over 200 clinical isolates of M. tuberculosis complex (MTBC) were collected from regional phthisiopulmonolo…
Tatiana Minogina, Leonid Lavrenchuk, Diana Vakhrusheva, Sergey Skornyakov
… for rational chemotherapy selection, especially when rapid drug susceptibility results are unavailable. Objectives To define the mutation patterns and frequency associated with resistance to isoniazid, rifampicin, fluoroquinolones and aminoglycosides in Mtb isolated from bone ti…
Ángel de Jesús Dzul-Beh, Karlina García‐Sosa, Andrés Humberto Uc‐Cachón, Jorge Bórquez, Luis Loyola, et al.
…ity shown by spathulenol was established as bactericidal on drug-resistant and susceptible strains of M. tuberculosis. Finally, cytotoxic activity on the Vero cell line (CC50 = 95.7 µg/ml) indicated that spathulenol is a selective anti-M. tuberculosis compound, with a selective i…
O. A. Zhurilo, А. І. Barbova, L.B. Skokluk, O. V. Chernov
…osis (NDPTB). Critical concentrations of anti-mycobacterial drugs (AMBD): H; R; E; Z; Lfx; Mfx; Am; cm; Lzd; Bdq; Dlm and Cfz were determined using the BACTEC MGIT system. Sequencing of MBT strains was performed on Illumina MiSeq equipment at the laboratory of microbiology and bi…
S. V. Sklyuev, Е. М. Жукова, N. V. Stavitskaya
The article describes a clinical case of a female patients with the continuous course of tuberculosis (more than 14 years). Despite the ongoing anti-tuberculosis therapy, the use of all possible surgical methods including valvular bronchial blocking, bacterial excretion persisted…
Irina Kostyukova, Anna Vyazovaya, О. А. Пасечник, Igor Mokrousov
Background . The prevalence of multidrug-resistant tuberculosis poses a serious public health problem, hampering the success of tuberculosis control programs around the world. Aim : Evaluation of epidemiological manifestations of tuberculosis and molecular genetic characteristics…
Akinduti Paul Akinniyi, Ajanaku Christiana Oluwatoyin, Oluwaseun Ejilude, Olumuyiwa Emmanuel Olukayode, Ofem Oluchi Gladys, et al.
Pulmonary morbidity caused by the clonally diverse multi-drug resistant Mycobacterium tuberculosis complex (MDR-Mtbc) is alarming due to increasing resistance to available antimicrobials which further exacerbates the disease burden. The constituted chemical compounds (chemotypes)…
Richmond Ronald Gomes
…tuberculosis infection. There are limited documents on multidrugresistant cervical tubercular lymphadenitis, but there is no evidence which may occur in TB endemic regions. Multidrug-resistant tuberculosis (MDR-TB) occurs when strains of Mycobacterium are resistant to the first-l…
А. I. Gayda, A. V. Abramchenko, M. I. Romanova, T. V. Toichkina, V. S. Burykhin, et al.
… treatment outcomes in patients with multiple/pre-extensive drug resistant (MDR/preXDR) tuberculosis who interrupted treatment at different time points. Subjects and Methods. 800 patients with MDR/preXDR tuberculosis were enrolled in the study, they were from all regions of the R…
Introduction. The treatment of patients with recurrent empyema of the pleural cavity associated with bronchial fistula of the main bronchus has been an urgent problem in phthisiosurgery for many decades. There are non-radi-cal methods of treatment using various variants of bron-c…
E. S. Ovsyankinа, Л. В. Панова, E. A. Krushinskaya, М. А. Багиров
The objective: to evaluate the effectiveness of short-curse chemotherapy regimens for treatment of MDR/pre-XDR tuberculosis in combination with surgery in older children and adolescents. Subjects and Methods. 51 patients with MDR/pre-XDR respiratory tuberculosis aged 13-17 years w…
Natalya Eremeeva, Tatyana Umpeleva, Diana Vakhrusheva, Sergey Skornyakov, Leonid Lavrenchuk
The problem of resistance of <i>Mtb</i> to antibiotics is a global threat to humanity. Along with drug resistance, <i>Mtb</i> can also develop resistance to other biocides (e.g. disinfectants), but this phenomenon is currently not well understood and became the goal of this …
MEH Mohamed, MM Mukhtar, ME Hamad, AA Daffalla
…ce, prevalence, diagnosis, and management outcomes of Multi Drug Resistant-Tuberculosis (MDR-TB) in Sudan.This study aimed to assess MDR-TB diagnosis, management, treatment outcomes and predictors of treatment in Abu-Anga TB Reference Hospital in Sudan between the period 2015 -20…