Showing 1–25 of 155 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Satyendra N. Shukla, Nitin Bhardwaj, Ashutosh Singh
…has emerged as a health risk due to its ability to adapt to drugs . The emergence of drug-resistant Mtb is affected by factors such as drug-resistant gene mutations, the efficacy of TB treatment, genetic background of the strain, and its ability to adapt to host and specific envi…
Urooj Ahmad, Anab Arshad, Sara Jadoon, Shahana Saba Salih, Hafsa Ahmed, et al.
…research was to find out the demographic characteristics of drug-susceptible and drug-resistant Tuberculosis in Khyber Pakhtunkhwa, Pakistan. Material and Methods: A retrospective survey was conducted on data from the TB Control Program Khyber Pakhtunkhwa recorded between 1st Jan…
Hasan Ismail Sultan, Ibrahim Khalil Ibrahim
…uberculosis (TB) is an international public health problem. Drug resistant tuberculosis is a considerable global health risk, leading the ongoing TB epidemic and increasing the morbidity and mortality of TB worldwide. Incomplete and insufficient therapeutic regimens can result in…
Susanna S van Wyk, Marriott Nliwasa, James A. Seddon, Graeme Hoddinott, Lario Viljoen, et al.
ABSTRACT Background Transmission of drug-resistant tuberculosis (TB) is ongoing, and many households face catastrophic costs when a member is diagnosed and treated for drug-resistant TB. Finding individuals with drug-resistant TB and initiating treatment as early as possible is i…
E. E. Lesnik, S. Ginda
…e main parameters of cellular, humoral immunity and natural resistance in tuberculosis patients with primary and acquired multiple drug resistance; to study the correlation of these parameters with clinical and radiological manifestations. Subjects and Methods. A prospective stud…
Yiwang Chen, Howard Takiff, Qian Gao
…g (WGS) has shown great potential in the rapid diagnosis of drug-resistant tuberculosis;1Finci I Albertini A Merker M et al.Investigating resistance in clinical Mycobacterium tuberculosis complex isolates with genomic and phenotypic antimicrobial susceptibility testing: a multice…
Nduagu Samuel Uchechukwu, ONYEAGWARA Ngozi Carol, Ogisi Festus Oritsemajemite, MBATA Godwin Chukwuemeka
…challenge facing the global efforts against tuberculosis is drug-resistance, which necessitates the use of aminoglycoside-based second line drugs that are known to have ototoxic potentials. Hearing impairment can be a source of social distress, professional disability and in some…
Naveen Pandhi, Ritu Dadra, Balbir Malhotra, Dr. P Prasanth
…ases were in the age group of 21-30 years, 147 (73.5%) were drug susceptible (DS) and 53 (26.5%) were drug resistant (DR). Amongst DR-TB cases, 21 (18.7%) were new and 32 (36.4%) were previously treated cases. Rifampicin mono-resistance was higher in both new (47.6%) and previous…
Nathan Hicks
…acy of this therapy has been undermined by the evolution of drug resistant Mtb strains, which are able to grow in the presence of clinically utilized antibiotics. The chromosomal mutations that cause drug resistance in Mtb have largely been identified, allowing for rapid genotype…
Josephine Amie Koroma, Mariama Mahmoud, Bailah Molleh, Stephen Sevalie, Adrienne K. Chan, et al.
…eone are missing each year. Challenges with notification of drug-susceptible TB can result in drug-resistant TB. The COVID-19 pandemic has further compounded these challenges, resulting in increased drug-resistant TB cases and poor treatment outcomes. This study highlights the ef…
Usharani Brammachary, Venkateswari Ramachandra, Suganthi Palavesam, Vidya Raj Cuppusamy Kapalamurthy, Aaina Muralidhar, et al.
…ry TB regimens consist of 6–9 months of daily doses of four drugs in the existing regimen that is extremely toxic to patients. The purpose of these longer treatments is to eliminate Mycobacterium tuberculosis, notorious for its ability to resist most antimycobacterial drugs, ther…
Letemichael Negash Welekidan (9243532), Solomon Abebe Yimer (7860920), Eystein Skjerve (64644), Tsehaye Asmelash Dejene (5159135), Håvard Homberset (165283), et al.
…etic diversity and lineage-specific association of Mtb with drug resistance among pulmonary tuberculosis patients.</p><p>Methods: Sputum samples were collected from pulmonary tuberculosis patients at six different healthcare institutions in Tigray, Ethiopia, between J…
Letemichael Negash Welekidan (9243532), Solomon Abebe Yimer (7860920), Eystein Skjerve (64644), Tsehaye Asmelash Dejene (5159135), Håvard Homberset (165283), et al.
…etic diversity and lineage-specific association of Mtb with drug resistance among pulmonary tuberculosis patients.</p><p>Methods: Sputum samples were collected from pulmonary tuberculosis patients at six different healthcare institutions in Tigray, Ethiopia, between J…
Jees Sebastian, Anooja Thomas, Carly Levine, Riju Shrestha, Shawn Levy, et al.
…atment are poor predictors of final therapeutic outcomes in drug-susceptible disease suggesting that treatment success depends on features that are hidden within a small minority of the overall infecting Mycobacterium tuberculosis (Mtb) population. We developed a multi-transwell …
Letemichael Negash Welekidan (9243532), Solomon Abebe Yimer (7860920), Eystein Skjerve (64644), Tsehaye Asmelash Dejene (5159135), Håvard Homberset (165283), et al.
…etic diversity and lineage-specific association of Mtb with drug resistance among pulmonary tuberculosis patients.</p><p>Methods: Sputum samples were collected from pulmonary tuberculosis patients at six different healthcare institutions in Tigray, Ethiopia, between J…
O. Omosebi, Olanrewaju S.O., Adejumo O.A.
…the country. Hence, this paper aims to model the outcome of drug-resistant-tuberculosis and drug-susceptible-tuberculosis patients in Oyo state of Nigeria using the logit function of estimating binary logistic regression model vis-à-vis identifying the success of these TB treatme…
Soedarsono Soedarsono, Alvian Fauzi, Anita Widyoningroem, Ni Made Mertaniasih
Background: Drug-resistant (DR) pulmonary tuberculosis (TB) is often associated with morbidity and mortality compared to drug-susceptible (DS) pulmonary TB. The infectiveness and pathological destruction of DR TB and DS TB strains are still controversial. Objectives: This study a…
Njoku Oluomachi Leticia, Iyanda Ayobola Abolape
…opper (Cu), iron (Fe), and selenium (Se)—in newly diagnosed drug-sensitive tuberculosis (DSTB) and drug-resistant tuberculosis (DRTB) patients compared to a control group without tuberculosis admitted in selected health facilities in Oyo State, Nigeria. Methodology: Over the cour…
Akheruz Zaman Ahmed, Nandini Bhat, Sneha Guruprasad Kalthur
…tiple organ toxicities induced by different anti-tubercular drug resistant groups like isoniazid resistance, rifampicin resistance, multidrug resistance including drug susceptible anti-tubercular drugs and their time of recovery from the toxicities induced by these drugs. Wistar …
Oriekot Anthony, Senai Goitom Sereke, Felix Bongomin, Samuel Bugeza, Zeridah Muyinda
…e. Radiology has an important role in the diagnosis of both drug-sensitive (DS) and drug-resistant (DR) pulmonary TB (PTB). This study aimed at comparing the chest x-ray (CXR) patterns of microbiologically confirmed cases of DS and DR PTB in Uganda. Methods: We conducted a hospit…
Sohag University
…is of all TB patients and prompt treatment with any form of drug-susceptible or drug resistant TB is fundamental. Identifying the pattern of drug resistance will ensure that the most effective therapy can be selected. The aim of this study is to assess the prevalence and patterns…
Vaidehi Mehta, Ramsha Ansari, Ira Shah
…year-old girl with steroid-resistant nephrotic syndrome and drug-sensitive pulmonary tuberculosis (Xpert MTB/Rif) and preextensively drug-resistant tuberculosis neuro-tuberculosis (Line Probe Assay). Mixed tuberculosis involving drug-susceptible and drug-resistant strains can hin…
Soraya Riefani, Juhairina Juhairina, Mohamad Isa, Erna Kusumawardhani, Haryati Haryati, et al.
… mortality. Based on its classification, TB is divided into drug-sensitive (DS) and drug-resistant (DR). Several risk factors susceptible to TB are malnutrition with low body mass index (BMI), vitamin D deficiency (VDD), and low total lymphocyte count (TLC) related to low immune …
Feng Yang, Hang Yu, Karthik Kantipudi, Alex Rosenthal, Darrell E. Hurt, et al.
… years, great progress has been made in care and control of drug-sensitive TB, whereas drug-resistant TB continues to be a worldwide public health problem that takes a heavy toll on both patients and the health care system. Early detection of drug resistance during a patient's fi…
M Dávid, Idah Orowe, Anthony Karanja, Hillary Kipruto
Background: Drug-resistant tuberculosis (DR-TB) is a form of antimicrobial resistance that is difficult and costly to treat. It is caused by TB bacteria that are resistant to at least one of the first-line existing TB medications, resulting in fewer treatment options and increasi…