Showing 1–25 of 200 documents
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Zahra Hasan, Sadia Shakoor, Rumina Hasan
…or use [[2]Nicol M.P. Zar H.J. New specimens and laboratory diagnostics for childhood pulmonary TB: progress and prospects.Paediatr Respir Rev. 2011; 12: 16-21Crossref PubMed Scopus (117) Google Scholar,[3]Hasan Z. Shakoor S. Arif F. Mehnaz A. Akber A. Haider M. et al.Evaluation …
Jean de Dieu Iragena, Achilles Katamba, Anandi Martin, Moses Joloba, Willy Ssengooba
…CT Background The implementation of rapid tuberculosis (TB) diagnostics is essential for TB control. Factors influencing their uptake in Africa are unknown. We conducted a survey to collect the status and document Predisposing, Enabling, and Need (PEN) factors influencing so that…
Christoph Lange, Professor
This study aims at identifying and evaluating novel diagnostic methods for children evaluated for respiratory tuberculosis. The investigators will use alternative samples like stool, urine, and masks to diagnose children with respiratory tuberculosis. Once diagnosed, the investig…
World Health Organization
This operational handbook provides practical guidance for the implementation of WHO policies and recommendations on rapid diagnostic technologies for tuberculosis (TB) and drug-resistant tuberculosis (DR-TB). The publication describes WHO-recommended diagnostic tests and testing …
І. В. Ліскіна, С. Д. Кузовкова, Л. М. Загаба, О.D. Nikolaeva
… diagnosed in 13 % of cases. The main methods of laboratory diagnostics were classical bacteriological methods — simple direct light microscopy and MBT culture, the positive results of which were obtained in only half of all studies, as well as molecular-genotypic tests. Prevalen…
World Health Organization
This operational handbook provides practical guidance for implementing WHO policies and recommendations on rapid diagnostic technologies for tuberculosis (TB) and drug-resistant tuberculosis (DR-TB). The publication describes WHO-recommended diagnostic tests for the detection of …
World Health Organization
…ted guidelines on tuberculosis, Module 3: diagnosis – rapid diagnostics for tuberculosis detection. The publication presents evidence-to-decision tables developed to support WHO recommendations on the use of rapid diagnostic technologies for tuberculosis and drug-resistant tuberc…
Anura David, Lyndel Singh, Manuel Pedro da Silva, Keneilwe Peloakgosi-Shikwambani, Zanele Nsingwane, et al.
Abstract Background Despite advances in molecular diagnostics, only 48% of newly diagnosed tuberculosis (TB) cases were confirmed using nucleic acid amplification tests (NAATs) in 2023. The BD MAX TM MDR-TB (MAX MDR-TB) assay, a moderate complexity NAAT, detects Mycobacterium tub…
Md Mahbub Ullah, Haris Riaz Khan, Aroosha Imran, Noman Ahmed, Kifayat Ullah, et al.
…view aimed to critically evaluate recent advancements in TB diagnostics, focusing on the integration of mass spectrometry, artificial intelligence, and genomics in comparison to conventional and molecular methods, and to assess their clinical applicability and limitations. Method…
World Health Organization
This web annex accompanies the third edition of the WHO consolidated guidelines on tuberculosis, Module 3: Diagnosis, and presents the evidence synthesis and analyses that informed recommendations on rapid diagnostic technologies for tuberculosis (TB) and drug-resistant TB detect…
Siavash Valafar
…revalence and co-occurrence, and their utility in molecular diagnostics. The genes commonly associated with INH resistance, katG, inhA, fabG1 , and the intergenic region oxyR’ - ahpC were considered in this review. In total, 52 articles were included describing 5,632 INH R clinic…
Dissou AFFOLABI, MD, MSc, PhD
Recent advances in molecular diagnostics of tuberculosis, especially the GeneXpert Mycobacterium tuberculosis/Rifampicin test have reduced the time to diagnose Rifampicin Resistant Tuberculosis (RR-TB) but only rifampicin resistance is diagnosed, leading to presumptive diagnosis …
World Health Organization
…ted guidelines on tuberculosis, Module 3: diagnosis – rapid diagnostics for tuberculosis detection. The publication provides comprehensive lists of studies included in the systematic reviews that informed WHO recommendations on rapid diagnostic technologies for tuberculosis and r…
World Health Organization
This web annex accompanies the third edition of the WHO operational handbook on tuberculosis, Module 3: Diagnosis, and provides technical information sheets on selected rapid diagnostic technologies for the detection of tuberculosis (TB) and drug-resistant tuberculosis (DR-TB). T…
World Health Organization
…base used in developing WHO policy recommendations on rapid diagnostics for tuberculosis detection and drug-resistance assessment.
Souleymane Hassane Harouna
Tuberculosis (TB) is a contagious disease caused by the Mycobacterium tuberculosis complex (MTBc) posing a global health challenge, particularly with drug-resistant TB (DR-TB) detection and treatment. Indeed, despite global efforts, only about 43% of DR-TB cases are diagnosed and…
M Park, Giovanni Satta, Meg Coleman, Laura Martín, Georgina Russell, et al.
<h3>Introduction</h3> The emergence of the new rapid polymerase chain reaction (PCR) test Xpert Ultra (Cepheid, Sunnyvale, CA, USA) has been shown to be more sensitive compared to smear microscopy as well as to the previous Xpert MTB/RIF for the detection of <i>Mycobacterium tube…
Swati B Gajbhiye, Madhavi V. Madkey, Dilip S Gedam
Background: Tuberculosis (TB) kills close to half a million Indians every year. Lack of reliable rapid diagnostic techniques for TB hampers timely diagnosis and leads to continued disease transmission, causing significant morbidity and mortality. The potential of newly recommende…
Usanee Anukool, P Phunpae, Chayada Sitthidet Tharinjaroen, B Butr-Indr, Sukanya Saikaew, et al.
Usanee Anukool,1,2 Ponrut Phunpae,1,2 Chayada Sitthidet Tharinjaroen,1,2 Bordin Butr-Indr,1,2 Sukanya Saikaew,1&amp;ndash; 3 Nathiprada Netirat,4 Sorasak Intorasoot,1,2 Vorasak Suthachai,4 Khajornsak Tragoolpua,1,2 Angkana Chaiprasert5 1Division of Clinical Microbiology, Depa…
Nicholaus P. Mnyambwa
Tuberculosis remains one of the world’s deadliest infectious diseases in resource-limited settings, including Tanzania. Diagnostic challenges and minimal information on resistant tuberculosis complicate building effective management strategies. The current study employed whole ge…
Noura Mohammadnabi, Jebreil Shamseddin, Mobina Emadi, Ali Bayat Bodaghi, Mahdieh Varseh, et al.
BACKGROUND: The infection caused by Mycobacterium tuberculosis arises from a complex interplay between the host immune system and the bacteria. Early and effective treatment of this disease is of great importance in order to prevent the emergence of drug-resistant strains. This n…
Bjorn Moum, M.D Ph.D, Gunnar Bjune, M.D Ph.D
…eases. By using non-invasive rapid tests one wishes to make diagnostics available to resource poor settings. Ideally, referrals to invasive diagnostic procedures would decrease, thus liberating economic and staff resources. Furthermore, patients may avoid unnecessary, expensive a…
World Health Organization. Regional Office for South-East Asia
The Xpert MTB/RIF assay is platform technology that has the potential for being used for screening for infectious and non-infectious diseases including HIV, malaria and detection of HPV for cervical cancer. The TB platform was completed in 2009 and is considered an important brea…
Sanjay Singh Negi, Priyanka Singh, Sachin Chandraka, Ujjwala Gaikwad, Padma Das, et al.
Introduction: Effective management of Extrapulmonary Tuberculosis (EPTB) requires simultaneous identification of Mycobacterium tuberculosis (M.tuberculosis) complex, NonTuberculous Mycobacteria (NTM) and Rifampicin (RIF) sensitivity pattern for early and effective evidence based …
Assiut University
* Detection of sensitivity and specificity of microscopic examination and Molecular studies using polymerase chain reaction (PCR) Mycobacterium tuberculosis (MTB)/ non tuberculous mycobacterium (NTM) MDR-TB compared to culture which is the gold standard technique in the diagnosis…