Showing 1–25 of 29 documents
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Heiman F Wertheim, PhD
Detection of M. tuberculosis in clinical specimens of children has a low sensitivity because specimens are either difficult to collect or contain low levels of M. tuberculosis. Diagnostic criteria are non-specific and culture confirmation is challenging, as sputum samples are not…
M R Marll, M Magee, N Glover, T Ngwanto, N Mofokeng, et al.
Abstract Rationale Approximately half of all tuberculosis (TB) survivors develop post-TB lung disease (PTLD), defined as persistent respiratory abnormalities despite a microbiological cure. Fibrosis, which typically presents as a restrictive ventilatory impairment on pulmonary fu…
Prince Malonda ma Ndungi, Blaise Idiamwana Kutokama, Bijou Masokolo Malamba, Dosithée Ngo-Bebe
Background Tuberculosis, the second deadliest infectious disease in the world after COVID-19, is caused by Mycobacterium tuberculosis. This bacterium most commonly affects the lungs. Economic and financial barriers can hinder access to healthcare services for the diagnosis and ma…
Hendra Subroto, Ida Parwati, Bachti Alisjahbana, Coriejati Rita, Yuhpita Indah Efriyani, et al.
There are still limitations in the diagnosis of tuberculosis (TB), and developing monitoring tools to predict treatment outcomes for TB patients is important. Sputum collection is not only challenging but also has low sensitivity when used as a diagnostic specimen. Interferon gam…
Helena Rabie, Marieke M. van der Zalm
Rapid microbiological confirmation of Mycobacterium tuberculosis (M tuberculosis) in sputum with nucleic acid amplification tests (TB-NAAT) is an important step to diagnose tuberculosis and to identify possible drug resistance. These tests significantly increase the diagnostic yi…
Abdulrhman Awadh Alharbi, Ibrahim Muhammad Al-Arej, Abdullatif Suliman Alsayegh, Meshal Ibrahim Zaid Al Owias, Bader Sayah Alanezi
Background: Tuberculosis (TB) is a highly infectious disease with a long history of impacting global health. Despite the availability of effective treatments, TB remains a significant cause of morbidity and mortality, particularly in low- and middle-income countries and among HIV…
Adithya Cattamanchi, MD
As part of the ongoing efforts within the Rapid Research in Diagnostics Development for TB Network (R2D2 TB Network) study, the Candidate Clinical Correlate as Prognostic Outcome for TB (C3PO) study serves as a supplement aimed at evaluating predictors and novel biomarkers of rec…
Digby F. Warner, Robin Wood
…ho is ill, and the development of improved point-of-care TB diagnostics remains a priority. Recent advances include expanding the GeneXpert molecular assay to detect multi-drug resistance [8], the use of whole-genome sequencing direct from clinical samples [9] and biomarker-based…
Wilber Sabiiti, Emmanuel Musisi, Bariki Mtafya, Peter M. Mbelele, Khalide Azam, et al.
<h3>Background</h3> Tuberculosis (TB) treatment is long and complex. Here we summarise data from EDCTP-funded studies of the Tuberculosis Molecular Bacterial Load Assay (TB-MBLA) as a TB treatment monitoring tool. <h3>Methods</h3> Treatment naïve participants from four Sub-Sahara…
Carolina Ochôa Matos, João de Menezes Aguiar, Joaquim Polido‐Pereira, Elsa Vieira‐Sousa, João Janeiro, et al.
The patient, a 74-year-old man, presented with mechanical pain in left hip. He had previously undergone physiotherapy, which was discontinued five months earlier following suspicion of a gluteal hematoma. He also reported a 9-kg weight loss over a year. Pelvic x-ray revealed eros…
Kranti Garg
The discrimination and social isolation associated with the contagiousness of the disease prevents the patient and his family members from accepting the diagnosis, disclosing it to the people around and seeking health care. The heterogeneity in behavioral responses spans from psy…
Irina Shabalina, Ilya Sivokozov, Dmitry Dedushkin, Tatyana Smirnova, Svetlana Shishova, et al.
<b>Aim:</b> To assess the rate of Detection Acid Fast Bacilli (AFB) in specimens of rEBUS and conventional bronchoscopy in comparison with another methods supporting diagnosis of pulmonary TB <b>Methods:</b> 176 patients (84 m and 92 f), aged 13-75 years, were undergoing bronchos…
Yu.O. Matviienko, О. M. Rekalova, V.М. Zhadan, S.H. Yasyr, А.В. Тараненко, et al.
OBJECTIVE. To study the diagnostic capabilities of integral hematological indices (IHI) in drug-sensitive tuberculosis (DSTB) after a previous coronavirus disease (COVID-19) under the influence of chronic stress caused by martial law. MATERIALS AND METHODS. A retrospective analys…
Mustafa Singapurwala, Poonam Gupta, Rohit Mishra, Amar Mandil, Swapnil Jain, et al.
…s early detection of DSTB and DRTB cases with the genexpert diagnostics, use of potent regimen and preventive care of household contacts. However, a simultaneous multi-dimensional uplift of socioeconomic, educational, nutritional status, personal health and hygiene etc., of the c…
Jennifer Cohn, MD, Martina Casenghi, PhD
… care and strengthening access to WHO-recommended drugs and diagnostics. Integration refers to supporting TB activities, such as screening and TB sample collection for children, into non-TB health care services, such as general pediatric outpatient clinics. Decentralization refer…
Njoku Oluomachi Leticia, Iyanda Ayobola Abolape
Objective: This study investigates the interplay between specific trace elements particularly —zinc (Zn), copper (Cu), iron (Fe), and selenium (Se)—in newly diagnosed drug-sensitive tuberculosis (DSTB) and drug-resistant tuberculosis (DRTB) patients compared to a control group wi…
Tran Duong Thai, Nut Nithimongkolchai, Benjawan Kaewseekhao, Janejira Samarnjit, Chutipapa Sukkasem, et al.
Mycobacterium abscessus (M. abscessus) infection is a significant public-health concern due to its resistance to multiple antibiotics and associated treatment challenges. There is a pressing need for a rapid and effective method capable of reliably identifying M. abscessus drug r…
Olanisun P Adewole, MD, Bolanle A Omotoso, MD
Tuberculosis (TB) is caused by mycobacterial organism. It is the leading infectious disease cause of death globally, with more than 10 million new cases and over 2 million deaths annually. Developing countries bear the greatest brunt of the disease. The long duration of current t…
Susanna S van Wyk, Marriott Nliwasa, F. Lu, Chih-Chan Lan, James A. Seddon, et al.
<sec> <title>BACKGROUND</title> Finding individuals with drug-resistant tuberculosis (DR-TB) is important to control the pandemic and improve patient clinical outcomes. To our knowledge, systematic reviews assessing the effectiveness, cost-effectiveness, acceptability, and feasib…
Oriekot Anthony, Senai Goitom Sereke, Felix Bongomin, Samuel Bugeza, Zeridah Muyinda
Abstract Background: Tuberculosis (TB) is one of the leading causes of death worldwide. Radiology has an important role in the diagnosis of both drug-sensitive (DS) and drug-resistant (DR) pulmonary TB (PTB). This study aimed at comparing the chest x-ray (CXR) patterns of microbi…
Tijani Sulaimon
We demonstrate not only that sensitivity and specificity by themselves offer a limited view into the performance of a test, but also that these metrics are not intrinsic to a test, but vary with disease prevalence.More generally, the contextual 'spectrum of disease' -which, in pr…
Naveen Pandhi, Ritu Dadra, Balbir Malhotra, Dr. P Prasanth
This is an observational prospective study, which included 200 microbiologically confirmed cases of tuberculosis (TB) which came to outpatient department or got admitted in the wards. Clinico-diagnostic profile of these cases was determined. The collected data were documented, co…
Ismaheel O. Lawal, Bernard Fourie, Matsontso Mathebula, Ingrid Moagi, Thabo Lengana, et al.
296 Background: FDG PET/CT imaging at the completion of anti-tuberculosis therapy (ATT) may show residual metabolically activity (RMA) in patients considered cured at end of treatment (EOT) based on current standard of care diagnostic definitions. The significance of RMA as a ris…
Benjamin WYPLOSZ, Ph
The objective of the present study is to confirm in a multicentric study the utility of our viability test in large cohort of smear-positive pulmonary tuberculosis patients under treatment and to determine if the test could help physicians to discontinue isolation measures in hos…
Otsuka Pharmaceutical Development & Commercialization, Inc.
This trial will assess the safety and efficacy of OPC-167832 combined with delamanid and bedaquiline in participants with drug-susceptible tuberculosis (DS-TB) administered for 17 weeks compared to rifampin, isoniazid, ethambutol, pyrazinamide (RHEZ) administered for 26 weeks. E…