Showing 1–25 of 87 documents
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Sanjeev Sinha, Himanshu Thukral, Imtiyaz Shareef, Devashish Desai, Binit Kumar Singh, et al.
…e. Methods: This randomized double-blind placebo-controlled trial was conducted in three sites in India. HIV negative participants aged 15-60 years with sputum smear positive PTB were recruited according to the Revised National Tuberculosis Control Program guidelines and were ran…
World Health Organization
Rapid advances in genomic technologies are transforming clinical research and enabling more precise approaches to disease diagnosis, treatment and prevention, yet their application remains uneven across populations and settings. This analytical report provides a global snapshot o…
Su-Won Lee, Yee Ran Lyu, Si Yeon Kim, Won‐Kyung Yang, Seung‐Hyung Kim, et al.
… a combined formulation containing four herbs, and has been clinically used for bronchitis in South Korea. We conducted a phase II, randomized, double-blind, and placebo-controlled, multicenter trial to evaluate its efficacy and safety. Patients with acute bronchitis or AECB were…
Kohei Fujita, Naoki Fujimoto, Saiki Yoshimura, Shogo Toyama, Takanori Ito, et al.
…t common adverse events (13.8%), followed by fever (10.3%). Clinical trial registration: This retrospective study was registered in the UMIN Clinical Trials Registry (registration No. UMIN000055755). This clinical trial was registered on 6 October 2024 and is publicly available.
Zeguang Zheng, Wuzhuang Sun, Jieying Hu, Zhijun Jie, Jin‐Fu Xu, et al.
…ODS: This prospective, randomized, double-blind, controlled clinical trial in 10 centres enrolled patient with AECOPD and a Breathlessness, Cough, and Sputum Scale (BCSS) score of at least 6 points. Eligible patients were randomly assigned (in a 1:1 ratio) to receive either hydro…
Wang Chung Kwok, Shung Kay Samuel Chan, Ka Yan Chiang, Jcm Ho
…ECOPD. Methods This is a double‐blind randomized controlled trial. Patients will be randomized in 1:1 ratio to receive oral NAC at 600 mg twice daily or placebo twice daily with standard of care. Partial pressure of oxygen (PaO 2 ), partial pressure of carbon dioxide (PaCO 2 ) an…
Аlbert R. Muslimov, Pavel Zhelnov
…erculosis based on nucleic acids in development, both in preclinical and clinical studies, if any, and to provide an overview of their formulations of choice.METHODSEligibility criteria: Records will be eligible for inclusion if they report any (in vitro, in silico, or in vivo) d…
Hayley A. Scott, Lisa G. Wood, Evan J. Williams, Natasha Weaver, John W. Upham
…cipants (75% female; mean age, 33.4 [9.9] yr) completed the trial. Moderate exercise induced a significant reduction in sputum eosinophil count (−173 [−337 to −10]; P = 0.032) and sputum percentage eosinophils (−2.2 [−4.9 to 0.5]; P = 0.049) relative to control. Vigorous exercise…
Zeguang Zheng, Kai Yang, Geoffrey Liu, Xiuhua Fu, Huijie He, et al.
…nter, randomized, double-blind, placebo-controlled, phase 3 trial at 19 centers in China. Hospitalized adult patients with mucopurulent sputum and expectoration difficulty were recruited. Patients were randomized by 1:1 to receive inhalation of either ambroxol hydrochloride solut…
Human Sciences Research Council
…his pragmatic, open-label, individual randomised controlled trial was done in nine clinics in Johannesburg, South Africa. Participants (aged ≥18 years) undergoing investigation for tuberculosis were randomly assigned (1:1) to the intervention group or control group (standard of c…
Jagannath Purushothama
…ebo controlled, block- randomized, double-arm, single blind trial will be experimented between March 2019 and August 2022 in Mangaluru, India, with a sample size of 300 in both the arms. The intervention group will be prescribed with nicotine polacrilex chewing gums along with br…
Yoshihiro Kanemitsu, Motohiko Suzuki, Kensuke Fukumitsu, Takamitsu Asano, Norihisa Takeda, et al.
…indicators of Th2-driven inflammation in the lower airways. TRIAL REGISTRATION: This study was registered on the UMIN Clinical Trials Registry (Registry ID UMIN000018672).
Chang Liu, Xin Wang, Yue Wang, Yuanyu Zhao, Huiwen Guan, et al.
…he anesthesia management of double-lumen endotracheal tube. Trial registration : This clinical research was registered at the Chinese Clinical Trial Registry(www.chictr.org.cn,ChiCTR2000040188).
J. Nancy Hilda, Gopalan Narendran, Banu Rekha VV, Elizabeth Hanna Luke, Ponnuraja Chinnaiyan, et al.
…our to prevent mortality caused by this co-infection. <bold>Clinical trial registration:</bold> Two studies were registered with the Clinical Trial Registry (CTRI 2008/091/000024 & NCT00933790).
Xiao Li, Li Wen, Lianjie Sun, Junyi Ren, Ying Xu, et al.
… dysfunction. Reducing pulmonary inflammation and improving clinical symptoms is the focus of current treatment. Low-intensity pulsed ultrasound (LIPUS) can mitigate inflammation and inhibit edema formation. We aimed to investigate the efficacy of therapeutic LIPUS in improving l…
Karikalan Nagaraj, Bella Devaleenal Daniel, Chandra Suresh, Dhanalakshmi Angamuthu, Shobana Palanisamy, et al.
…based interventions under the National TB program of India. Clinical trial registration The study has been registered in the Clinical Trial Registry of India CTRI/2024/05/066847.
Kohei Fujita, Yutaka Ito, Yuki Yamamoto, Osamu Kanai, Takuma Imakita, et al.
…ormer had more localized lung inflammation than the latter. Trial registration : This trial was prospectively registered in the Clinical Trials Registry (UMIN 000027652).
Kohei Fujita, Yutaka Ito, Yuki Yamamoto, Osamu Kanai, Takuma Imakita, et al.
…ormer had more localized lung inflammation than the latter. TRIAL REGISTRATION: This trial was prospectively registered in the Clinical Trials Registry (UMIN 000027652).
Steven Taylor, Kerry L. Ivey, Peter G. Gibson, Jodie L. Simpson, Geraint B. Rogers
… in adults with persistent symptomatic asthma in the AMAZES trial (Australian and New Zealand Clinical Trials Registry (ANZCTR), number 12609000197235) [1]. However, response to treatment was variable between participants and the characteristics of those who experience most clini…
Wenwen Sun, Zhengwei Dong, Yiming Zhou, Kunlong Xiong, Hongcheng Liu, et al.
…infection were detected at one time by mNGS. All mNGS-based clinical decisions were made within 2 days.Conclusions The mNGS could accurately and quickly detect fungi and mycobacteria in FFPE specimens from postoperative granuloma specimens and identify the pathogens to the specie…
Zhenfan Wang, Xue Tian, Feng Yang, Lu Wang, Hao Li, et al.
…s under near-infrared imaging. The primary outcomes of this trial were the detection rate and background-tumour ratio of lung nodules, and the secondary objectives were time to search for nodules and operative time to nodules excision. RESULTS: A total of 50 pulmonary nodules in …
Naomi Chapman, Vinícius Cavalheri, Elizabeth F. Smith, Jamie Wood, Luke W. Garratt, et al.
…utum. METHODS: This was a non-blinded randomised controlled trial where adults hospitalised with a CF exacerbation were allocated to an experimental intervention (EIx; MetaNeb) or a control intervention (CIx; their usual ACT). Both groups underwent twice-daily supervised airway c…
Mouquan Shen, Li Guo, Ya Li, Ruitong Gao, Xin Sui, et al.
…D ANALYSIS: We propose a single-blind randomized controlled trial using 75 hospitalized patients diagnosed with COPD with excessive sputum production. The patients will be divided into three groups. The intervention group will receive active cycle of breathing techniques combined…
Ying Hu, Zhiqiang Chen, Jing Zeng, Shouyan Zheng, Liujuan Sun, et al.
…lls to Tregs under certain conditions. However, no relevant clinical studies have been reported on the association between IDO activity and Th17/Treg imbalance in children with allergic asthma. The goal of this study was to test whether indoleamine 2,3 dioxygenase (IDO) participa…
Christopher A. Berger, R. Crowder, A. Kityamuwesi, Noah Kiwanuka, M. Lamunu, et al.
… We conducted a pragmatic, stepped-wedge cluster randomized trial including all adults treated for drug-susceptible pulmonary TB at 18 health facilities across Uganda over eight months (December 1, 2018-July 31, 2019). Facilities were randomized to switch from routine (control pe…