Showing 1–25 of 200 documents
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Maral Budak, Joseph M. Cicchese, Pauline Maiello, H. Jacob Borish, Alexander G. White, et al.
…ng more effective and more patient-friendly antibiotic drug regimens to increase patient compliance and decrease emergence of resistant TB. Moxifloxacin is one promising antibiotic that may improve the current standard regimen by shortening treatment time. Clinical trials and in …
Jie Tan, Jun Huang, Jin Wang
…dy aimed to evaluate the efficacy of bedaquiline-containing regimens versus conventional regimens for cavitary MDR-PTB based on CT imaging. This retrospective study included 100 patients with cavitary MDR-PTB treated from June 2023 to June 2025. Patients were divided into a Conve…
Soedarsono Soedarsono
… prolonged QT side effects are also neededto prevent switch regimens that can affect the patient’s psychological condition.
Katherine Cobb, Aline Wilson, Nikolas Rae, Neil Stevenson
…fety data is awaited, compassionate use of alternative drug regimens within strict monitoring guidelines should be considered.
Tsong H. Chang, Yuxia Zhang, Yanming Sun, Zhiyuan Zhao, Fengxia Liu, et al.
…(RR) TB patients who were switched to contezolid-containing regimens due to adverse reactions during treatment with linezolid-containing regimens were included. Linezolid was administered 600mg once daily for 6-24 weeks, contezolid was given 400mg twice daily for 4 months to 1 ye…
Soumana Boubacar Soumana, Abdourahamane Yacouba, Cheikh Aboubacar Abdoul Lawi, Ibrahim Oumar, Bassirou Souleymane, et al.
Background The emergence of extensively drug-resistant tuberculosis (XDR-TB) poses a serious challenge to global tuberculosis control, particularly in high-burden countries like Niger. In 2021, a new fully oral, shorter treatment regimen, named regimen C, was adopted nationally. …
National Institute of Allergy and Infectious Diseases (NIAID)
The purpose of this study is to compare a 6-month regimen of high-dose rifampicin (RIF), high-dose isoniazid (INH), linezolid (LZD), and pyrazinamide (PZA) versus the World Health Organization (WHO) standard of care (SOC) treatment for tuberculosis meningitis (TBM). Rationale: T…
Zh. T. Zhandauletova, Е. И. Никишова, А. O. Мaryandyshev, K. S. Serikbaeva, M. M. Adenov, et al.
…he objective : to assess the safety and compliance with new regimens for preventive treatment of drug susceptible and drug resistant tuberculosis. Subjects and Methods . The study was carried out in Almaty, the Republic of Kazakhstan; 182 patients from the groups facing the high …
Karnappa Bhangari, Basavaraj Sangolli, H. N. Jagadeesha
A comparative assessment of daily dosage regimen versus intermittent treatment regimen of tuberculosis at the RNTCP centres in Chitradurga district - IJIRM- Print ISSN No: - 2581-4214 Online ISSN No:- 2581-4222 Article DOI No:- 10.18231/j.ijirm.2020.037, IP Indian Journal of Immu…
Moti Chapagain, Tawanda Gumbo, Scott K. Heysell, Shashikant Srivastava
…in and ethambutol. Unfortunately, therapy duration for both regimens lasts for years. In this study, we administered tedizolid, minocycline, clarithromycin, and rifapentine as monotherapy as well as novel combinations in the intracellular hollow-fiber model system of M. kansasii …
Andi Ibnu, Hajar Azis, Ngakan Putu, Persama Putra, Teguh Rahayu Sartono, et al.
however, there was persistence of A repeat chest scan showed interval development of cavity formation with no significant change in size of the mass lesion. The patient was referred to thoracic surgery and underwent right lower lobectomy. Intra-operative findings include a well-c…
Seyed Saeed Hashemi Nazari, Saeid Fallah, Vahideh Raeisi
Context The number of tuberculosis (TB) patients and multidrug-resistant species of Mycobacterium tuberculosis are increasing worldwide. Effective treatment is still the key factor to control TB in the society. Aims The aim of the study was to compare the efficacy of fixed-dose c…
Alex Nachman, Zain Chagla
CLINICAL IMPACT RATINGS: GIM/FP/GP: [Formula: see text] Infectious Disease: [Formula: see text] Pulmonology: [Formula: see text].
World Health Organization
Tushar R. Sahasrabudhe
… Revised National TB Control Programme (RNTCP) as DOTS plus regimens. These regimens involved use of less potent second-line drugs which were at least 5 and up to 7 in number based on grouping of medicines, and were required to be taken for a longer duration, often ranging from 1…
Nirmal Kumar Jain
…ed guidelines published in March 2020 recommends fully oral regimens for drug-resistant tuberculosis (DR-TB) that is isoniazid-resistant TB, rifampicin-resistant TB (RR-TB), multi-DR-TB (MDR-TB), and extensively DR-TB (XDR-TB). These regimens are said to be game changer for these…
Dick Menzies, MD
…fe; 2. Tuberculosis Preventive Treatment (TPT) with shorter regimens are superior with respect to acceptance, completion, and costs; 3. 4 months of Rifampin 10mg/kg (4R10) is the safest regimen, but is completed by \<80% of patients; 4. The safety of 2 months of Rifampin 20mg/kg …
Durga Balagopalan
All oral regimens have become a great advancement in the treatment of multidrug-resistant tuberculosis (MDR-TB). Earlier, the treatment of MDR-TB was considered long, with side effects and more relapse rate. The best estimate of the proportion of people diagnosed with MDR/Rifampi…
Courtney M. Yuen, Moorine Sekadde, Brian Kaiser, Brenda Waning, Stephen M. Graham
…for TB disease or infection, the length of common treatment regimens poses a challenge to the implementation of child-friendly TB care. Undergoing TB disease treatment, which previously ranged from 6 months for drug-sensitive TB to up to 2 years for multidrug-resistant TB (MDR-TB…
Qiaoling Ruan, Jingyu Zhou, Shufeng Weng, Lingyun Shao, Wenhong Zhang
…ts. The World Health Organization recommends LTBI treatment regimens, including 6 or 9 months of once-daily isoniazid (INH, H), 4 months of once-daily rifampin (RIF, R), 3 months of once-weekly rifapentine (RPT, P) plus INH (3HP), 3 months of once-daily RIF plus INH, or 1 month o…
Sarah Meredith, MD, Andrew Nunn, PhD
… the rise, there is a need to investigate optimal treatment regimens using effective drugs. The STREAM study is an international, multi-centre, parallel-group, open-label, randomised, controlled trial in patients with multi-drug resistant tuberculosis (MDR-TB) including patients…
sha wei
…osis infection, we identified several new experimental drug regimens among billions of possible drug-dose combinations that outperform the current Standard Regimen. We used the PRS platform to optimize the in vivo drug doses of novel regimens (designated PRS regimen) in a mouse m…
Susan Dorman, MD, Payam Nahid, MD, MPH, Susan Swindells, MBBS, Richard Chaisson, MD, Ekaterina V Kurbatova, MD, PhD, MPH
…of this study is to determine whether one or two four-month regimens of tuberculosis treatment are as effective as a standard six-month regimen for treatment of pulmonary tuberculosis (TB). All three regimens are administered daily, seven days each week, with direct observation o…
Sedona Sweeny
…iming to assess the costs to patients and providers of such regimens and to estimate the cost-effectiveness and poverty impact of an introduction of new MDR-TB regimens in the three countries participating in the main study. Multidrug resistant tuberculosis (MDR TB), tuberculosi…
Oki Nugraha Putra, Telly Purnamasari
…t tuberculosis (XDR-TB) and MDR-TB[3]. It demonstrates that regimens containing pretomanid and BPaL or BPaLM were associated with favorable outcomes (cured). BPaLM consists of bedaquiline (400 mg once daily for the initial two weeks, followed by 200 mg thrice weekly for 22 weeks)…