Showing 1–25 of 53 documents
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Woo Joo Kim, M.D, Ph.D
Healthy adults will be once administered GC3107(BCG Vaccine) Intradermally. Healthy adults will be once administered GC3107(BCG Vaccine) Intradermally. Tuberculin Skin Test(TST) will be conducted after 84+7 days after IP injection and TST result will be read in 48\~72 hours.
Helen McShane
This is a human pilot study of 16 healthy BCG-naïve volunteers to quantify BCG from the BCG vaccination site. Volunteers will be vaccinated with BCG. The first 8 will go on to have a punch biopsy and suction blister of the vaccination sites at 2 weeks post vaccination (arm A) the…
Mark F. Cotton, Helena Rabie
…lth Organization, Geneva2015Google Scholar and an effective vaccine was a key component of this strategy. Although tuberculosis vaccine research began in earnest in the 1990s, a strategic blueprint for tuberculosis vaccine development beyond the BCG vaccine was released in 2012. …
Fadel Sayes, Wafa Frigui, Alexandre Pawlik, Cécile Tillier, Magali Tichit, et al.
Abstract The currently licensed anti-tuberculosis (TB) vaccine, Mycobacterium bovis BCG, provides limited protection against pulmonary TB in adolescents and adults, the main cause of TB transmission and mortality. To obtain an improved BCG-based vaccine candidate with increased i…
Ahmed M. Abbas, Asmaa Abou‐Bakr, Nermeen Bahaa, Sherry Michael, Marco Ghobrial, et al.
… relationship between COVID-19 and Bacille Calmette Guérin (BCG) vaccine is still under investigation, and we aim to clarify this matter. Bacille Calmette Guérin is a live attenuated tuberculosis vaccine. BCG vaccination of adult humans induces strained circulating monocytes havi…
Helen McShane
…nd highly immunogenic in mycobacterially naïve individuals, BCG vaccinated individuals and M.tb latently infected individuals. We will use the same vaccination regime in this study. Participants will be defined as being infected with M.tb.if they have a positive Elispot response …
Hafsa Farooq, Hamna Khan, Nimra Akhtar
…ost TB cases (95%) are found in low-income nations. Neonate BCG immunization is recommended by the WHO in countries with a "high prevalence" of tuberculosis.Objective: To determine the frequency of BCG vaccination in children diagnosed with pulmonary Tuberculosis at a tertiary ca…
Padmini Salgame, Vaishnavi Kaipilyawar
…or the largely variable protective effect against TB of the vaccine Bacille Calmette-Guerin (BCG) is not understood.In this study, we investigated whether epigenetic mechanisms are involved in the response of immune cells to the BCG vaccine.We isolated peripheral blood mononuclea…
Serum Institute of India Pvt. Ltd.
This is a Phase II/III trial with two groups of adults successfully cured of category 1 pulmonary TB receiving either VPM1002 or placebo. Single dose of VPM1002 / placebo will be administered to calculate efficacy of the vaccine against TB recurrence. The study is designed as a …
Helen McShane
This study is preliminary to proving that this vaccine could protect against tuberculosis in humans. Although there is no proven data to show that infants will benefit directly from participation in this study by being protected against TB, MVA85A protection of mice, guinea pigs …
Özgül Kısa
…iency Syndrome (AIDS). Currently, Bacillus Calmette-Guérin (BCG) vaccine is used to prevent tuberculous meningitisand miliary disease, particularly in young children, but its protective efficacy is variable in adults. Therefore, there isan urgent need for the development of alter…
Ahyar Ahmad, Andriansjah Rukmana, Miski Aghnia Khairinisa, Dian Ayu Eka Pitaloka, Rosana Agus, et al.
…h challenge worldwide. Currently, Bacillus Calmette-Guerin (BCG) is the only vaccine available for TB prophylaxis. However, the efficacy of the BCG vaccine against adult pulmonary TB is considered inconsistent. This condition encourages researchers to look for more effective opti…
Helen McShane
…aring two different strains of the Bacille Calmette-Guérin (BCG) vaccine at standard and high dose. Currently, to assess vaccine efficacy against tuberculosis (TB) there is no alternative to large randomized controlled trials. These efficacy trials for novel TB vaccines are diff…
Trim Lajqi, Natascha Köstlin‐Gille, Christian Gille
… innate immune cells to exhibit rapid action with increased efficacy against subsequent infections. Here we will discuss the role of TRIM and its implications for infectious diseases in childhood. The Concept of Trained Innate Memory Although lacking an adaptive immune system, pl…
Professor Helen McShane, Professor Paul Moss
…linical challenge trial primarily to evaluate the safety of BCG challenge administered by the aerosol inhaled route in healthy, BCG naive UK adults. The trial will also look to evaluate and compare the amount of BCG recovered from the lungs and from the skin, following challenge …
Helen McShane, Gregory Hussey
This study is designed to evaluate the safety of the TB vaccine MVA85A in healthy children and infants in South Africa. A single vaccination with MVA85A has been shown to be safe and highly immunogenic in a wide range of subjects in previous clinical trials. In this trial,we will…
M B Mouton, R M Horowitz, V M Limbert, L Bachnak, L A Morici, et al.
…ldwide. Intradermally administered Bacille Calmette-Guerin (BCG) is the only licensed Tb vaccine; however, BCG has limited efficacy in adults and vaccination site reactions. Additional issues include exclusion of immunocompromised/pregnant individuals, waning protection with age,…
Abiola Oduwole, JP Mwankon, Joseph Okebe, EB Esu, Moriam Chibuzor, et al.
Background: The Bacille Calmette-Guérin (BCG) vaccine, given as a single dose, offers variable protection against Tuberculosis (TB). It is plausible that repeat doses could improve the effectiveness of the BCG vaccine in settings where the population remain at risk of the disease…
Y. Su, Yin Cao, R L Wang, E J Dong, Weihong Zhao, et al.
Currently, Bacille Calmette-Guerin(BCG) is still the only admitted vaccine to prevent tuberculosis around the world. The target population is infants and children, but its protective efficacy is limited. As more and more studies have shown that re-vaccination with BCG protects ag…
Jorge Barrios‐Payán, Cristian Alfredo Segura-Cerda, Dulce Mata‐Espinosa, Helle Bielefeldt‐Ohmann, Rogélio Hernández‐Pando, et al.
…cination with Mycobacterium bovis Bacillus Calmette-Guerin (BCG) is effective in controlling severe forms of TB in childhood, with limited efficacy in preventing lung disease in adults, which is further reduced by infection with Beijing strains.We previously showed that a standar…
Mark Hatherill
…oject is to demonstrate safety, immunogenicity and improved efficacy of the new live attenuated M. tuberculosis vaccine called MTBVAC in a Phase 3 efficacy trial in HIV-uninfected infants born to HIV-infected and HIV-uninfected mothers as compared to standard of care BCG vaccinat…
Ratih Pujilestari, Andriansjah Rukmana, Anis Karuniawati, M Usman, S Ismail, et al.
… Mycobacterium tuberculosis (Mtb). Bacille Calmette-Guérin (BCG) is the only licensed vaccine against TB, and it is effective in children but not in adults. The Vaccine Research Team, Department of Microbiology FKUI has developed a DNA-based TB vaccine candidate pcDNA3.1-rpfB. Th…
Solomon Jauro, Erica C. Larson, Janelle L. Gleim, Brendon M. Wahlberg, Mark A. Rodgers, et al.
…in people living with HIV (PLWH). Bacillus Calmette-Guérin (BCG), the only approved TB vaccine, is effective in infants, but its efficacy in adolescents and adults is limited. Here, we investigated the immune responses elicited by BCG administered via intravenous (IV) or intrader…
S.H. Choi, Jiyun Park, Jung Joo Hong, Sung Jae Shin, Ju Mi Lee
The Bacillus Calmette-Guérin (BCG) vaccine, the only licensed vaccine against tuberculosis (TB), has played a crucial role in mitigating severe manifestations of the disease, particularly in children. However, its effectiveness against pulmonary TB in adults remains variable, lar…
GSK Clinical Trials
…s who are PPD-positive either via previous vaccination with BCG and/or conversion to PPD positivity through exposure to Mycobacterium tuberculosis. The BCG vaccine has been widely available for several decades. It is easy and cheap to produce, and when given to neonates or young…