Showing 176–200 of 200 documents
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Andi Safutra Suraya, Fitriatul Jannah, Firnanda Erindia, Nurwahidah Nurwahidah, Ahla Chayatush Sholichah
…efulness of mobile health apps on adherence to TB treatment regimens and in healthcare workers.
 Method: This systematic review applied the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes (PRISMA) guideline. The results was reported in descriptive narrativ…
Tutik Kusmiati, Ni Made Mertaniasih, Johanes Nugroho Eko Putranto, Budi Suprapti, Nadya Luthfah, et al.
… of rifampicin-resistant (RR-TB) patients receiving shorter regimens. Correlation for all variables was analyzed. RESULTS: CRP, IL-1β, and QTc baseline showed significant differences between 45 RR-TB patients on intensive phase and continuation phase with p-value of <0.001, 0.040…
Akshada Manik Shinde, Mandar Manik Shinde
…s demonstrated that intermittent or thrice-weekly treatment regimens are associated with higher risks of unfavorable outcomes compared to daily regimens, particularly in patients with drug-sensitive TB.In response to this evidence and in alignment with the World Health Organizati…
Eden Suryoiman Winoto, Didi Candradikusuma
The continuing spread of Multidrug-Resistant Tuberculosis (MDR-TB), which is defined as TB that shows resistance to both isoniazid and rifampicin, become one of the most urgent and difficult challenges in TB control. In Indonesia, the estimated total DR-TB case incidence of 24,00…
Christian Lienhardt, MD
…mended by WHO. Patients will be treated with one of the two regimens that will be randomly allocated. A total of 2070 patients will ne recruited in the trial and followed-up for a duration of 2 years. The trial is multicentre, and conducted in 5 countries in Africa.
Е. П. Мышкова, Т. И. Петренко, Т. А. Колпакова
… the efficacy and safety of various anti-tuberculosis therapy regimens for multiple drug resistant (MDR) and extensive drug resistant pulmonary tuberculosis in the intensive phase of treatment lasting for 8 months minimum. Subjects and Methods . A single-center cohort prospective-r…
Soedarsono Soedarsono, Vicky Reinold Christofel Rampengan, Catur Agustiyanto, Yong‐Soon Cho
Introduction: The World Health Organization (WHO) has recommended the 9-month all-oral regimen for multidrug-resistant tuberculosis (MDR-TB) treatment. This regimen is expected to increase the treatment success rate. Bedaquiline, levofloxacin, and clofazimine are QT-prolonging dr…
Dumitru Chesov, Jan Heyckendorf, Maja Reiman, Sofia Alexandru, Ana Donica, et al.
…tients who received bedaquiline containing MDR-TB treatment regimens in the Republic of Moldova. <b>Methods:</b> We systematically analyzed the national electronic TB database and performed a retrospective comparison of treatment outcome in patients with MDR-TB who completed trea…
N. Yu. Nikolenko, D.А. Kudlаy, Borisov Se, T. E. Sannikova, N. P. Doktorovа
…ients in the group with bedaquiline-containing chemotherapy regimens reached the outcome of “treatment successfully completed” (patient was cured or transfered into the III group of dispensary follow-up) compared to 51.8% in the OBR group. The use of “new” etiotropic therapy regi…
Gwanita Nawariantina Perangin-angin, Bintang Yinke Magdalena Sinaga, Parluhutan Siagian, Putri Chairani Eyanoer
ABSTRACT Background: Indonesia ranked 2nd around the world for TB cases with case population continue increasing. In 2018, Shorter Treatment Regimen (STR) was introduced as a new regimen for treating MDR-TB patient. The aim of this study is to determine factors associated with tr…
Yong Soo Kwon
…nt adverse drug reactions associated with complex treatment regimens involving multiple drugs administered over prolonged periods. However, recent clinical trials, such as Nix-TB, ZeNix, NExT, MDR-END, TB-PRACTECAL, and BEAT-India, have demonstrated that shorter oral regimens yie…
Chalamcharla M. Manjula, J. P. Majra
Background: Daily regimen anti-tuberculosis treatment was adopted by Revised National Tuberculosis Control Programme (RNTCP) as a step to achieve tuberculosis elimination by 2025 in India. The change was implemented prior to completion of pilot study, which necessitated this stud…
Alena Skrahina, Natalia Yatskevich, Henadz Hurevich, Viatcheslav Grankov, Dmitry Klimuk, et al.
<b>Background:</b> New and repurposed TB drugs and shorter regimens can radically change the landscape for treating MDR-TB. In December 2019, the WHO issued “Rapid Communication” related to MDR-TB management; WHO reiterated their earlier recommendation that a majority of MDR-TB p…
Imran Nazir, Mohammed A Almatrafi, Iffat Imran, Sayed Rahman, H.M.M. Abdullahi, et al.
…his study aims to compare the efficacy of the two treatment regimens (oral doxycycline/rifampicin or ciprofloxacin versus IV gentamicin plus oral doxycycline/rifampicin or ciprofloxacin) in Brucella bacteremia. Methods In this single-center, retrospective cohort study, we analyze…
Masataka Matsumoto, Kaori Masuda, Kazumi Kaneshiro, Kiyonobu Takatsuki
<b>Background:</b> Poor adherence to treatment for <i>Mycobacterium avium</i> complex pulmonary disease (MAC-PD) is related to side effects (Adjemian J. et al. Ann Am Thorac Soc 2014; 11:9-16). An alternative to daily regimen is the less frequent administration but it requires th…
Nana Kiria, Zaza Avaliani, Tamar Togonidze, Lali Mikiashvili
<b>Background:</b> Short, all oral 6-month regimens of bedaquiline-pretomanid-linezolid (BPaL) were highly effective for the treatment of drug-resistant tuberculosis in clinical trials. Scarce data about the programmatic use of BPaL schemes. <b>Aim:</b> To assess the efficac…
Tawanda Gumbo, Moti Chapagain, Gesham Magombedze, Shashikant Srivastava, Devyani Deshpande, et al.
…t can be 18–20 months with multidrug resistance. Ultrashort regimens that cure regardless of resistance status [“pan-tuberculosis regimens”] would be a major step towards global tuberculosis control. Starting with seven drugs [bedaquiline, delamanid, pretomanid, OPC-167832, sutez…
Russell R. Kempker, Lali Mikiashvili, Yuan Zhao, David Benkeser, Ketino Barbakadze, et al.
…tients receiving bedaquiline- and delamanid-based treatment regimens for drug-resistant TB had similar characteristics and those receiving bedaquiline had better clinical outcomes. Our results provide an important first comparison of bedaquiline vs. delamanid containing regimens.…
Lovely Jain, Meenakshi Malik, Kulbir Kaur, Sarita Dogra, Abhishek Purohit, et al.
…rtaken to investigate the efficacy and safety of short-term regimens (STRs) for the treatment of DR-TB in children. Methods: We conducted a comprehensive literature search across PubMed, EMBASE, Scopus, CINHAL, Web of Science, Cochrane Library, major trial registries, and grey li…
Manoj Kumar Pippal Santosh
…tion). A total of 109 countries were using all -oral longer regimens for the treatment of MDR/RR -TB. Material and Methods: The present study is a hospital -based observational prospective non -randomized without a control group, which was performed at a nodal DRTB center, Depart…
Min Zhu, Yuanyuan Chen
…s in each group. The control group was treated with 2-month regimens of isoniazide, rifampin, ethambutol and pyrazinamide, followed by 4-month regimens of isoniazide, rifampin and ethambutol. The observation group was treated with 4-month regimens of moxifloxacin, rifampin, etham…
Wenhong Zhang, PhD.
…ontrol is poor adherence to long-term and complex treatment regimens. This is a multicenter prospective, non-inferiority randomized controlled study. The purpose of our study is a) to evaluate the tolerability, efficacy and pharmacokinetics/pharmacodynamics (PK/PD) of the high-d…
Saiduo Liu, Xinchun Ye, Fang Cheng, Kaijia Wu, Jiandan Yu, et al.
…nvestigated the clinical efficacy of bedaquiline‐containing regimens in the treatment of drug‐resistant pulmonary tuberculosis and the diagnostic value of computed tomography (CT). Methods We retrospectively analyzed the clinical diagnosis, treatment, and CT imaging data of patie…
Antonio Rivero, MD PhD, Luis Lopez-Crtés, MD, PhD, Rafael Castillo, MD, José Verdejo, MD, Miguel Angel García, MD, et al.
To evaluate adherence and safety of three regimens of chemoprophylaxis for tuberculosis (TB) in HIV-infected patients with positive tuberculin skin test. DESINGS: We performed a randomised, comparative and open clinical assay carried out in 316 HIV-infected patients. The patient…
Natalia Yatskevich, Elmira Gurbanova, G. L. Gurevich, E. M. Skryagina
…ective: to evaluate the safety of 39- and 24-week treatment regimens in the patients with rifampicin-resistant tuberculosis (RR-TB). Subjects and Methods. Cohorts of patients with RR-TB were treated with the following regimens: 550 patients received modified short course treatmen…