Showing 151–175 of 200 documents
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N.А. Lytvynenko, Yu. I. Feshchenko, Maryna Pohrebna, Yu.О. Senko, Л.М. Процик, et al.
…nce and the results of treatment in patients with pulmonary tuberculosis with different profile of the MTB resistance and a history of previous treatment.Materials and methods. A retrospective cohort study was conducted. The total number of patients included in the study — 1162 p…
Faiqah Umar, Dirayah Rauf Husain, Rosana Agus, Mochammad Hatta, Jamilah Jamilah, et al.
…s contribution to the resistance mechanism of Mycobacterium tuberculosis has increased the attention to efflux inhibitors usage as adjuvants in tuberculosis therapy. Therefore, this study examined the effect and interaction between efflux inhibitor towards first (isoniazid, strep…
Xinxin Ren, Zhihui Li, Xiuli Feng, Dan Cui
…RIF) in the rapid diagnosis of drug resistance in pulmonary tuberculosis patients, and to evaluate the role of X pert MTB/RIF in the screening of clinical trials. Methods With the method of comprehensive screening, Hebei Province Chest Hospital all early diagnosis of suspected pu…
Nahid Madadi-Goli, Kamal Ahmadi, Sharareh Khanipour, Shahin Pourazar Dizaji, Mahshid Nasehi, et al.
Introduction: Tuberculosis (TB) caused by the bacterium Mycobacterium tuberculosis remains a critical global public health concern due to the high morbidity and mortality rates. Mutation in atpE and Rv0678 genes contributes to drug resistance in M. tuberculosis. This study invest…
Rrezarta Bajrami, Alina Minias, Greta Lila
…to the World Health Organization, there were 10 million new tuberculosis cases, and the disease caused 1.5 million deaths in 2022. The incidence of tuberculosis in Kosovo was 34.4 per 100,000 population in 2022. To date, there is no information regarding the genetic composition o…
Scott W. Nelson
Dock & Discover: Sensitizing Mycobacterium tuberculosis to Oxidative Assault via MazG Inhibition To continue my summer of learning computational biology, I decided that I wanted to learn: 1) How to do Molecular Dynamics simulations and 2) How to do large-scale in silico docking f…
Farzam Vaziri
…gence and spread of multidrug resistant (MDR) Mycobacterium tuberculosis (M. tuberculosis) strains is a critical global health problem. In order to shorten the course of treatment and its effectiveness, it is essential to gain an in-depth insight into the genetic diversity, drug …
M. Kumar, Sonam Sharma
Tuberculosis (TB), which is triggered by Mycobacterium tuberculosis, continues to be a prominent contributor to infectious disease-related deaths worldwide, even after many years of attempts to manage it. Exceeding 10 million instances and surpassing a million fatalities each yea…
В. Е. Новиков, Natalia E. Usacheva, T. V. Myakisheva
… children: Aetiotropic therapy is used for the treatment of tuberculosis (TB) in children, as well as in adult patients. Anti-tuberculosis drugs (anti-TB drugs) are divided into 3 lines, taking into account drug sensitivity in Mycobacterium tuberculosis (MBT). First-line anti-TBd…
Marie José Bajani Kabedi, Steve Ahuka, Octavie Metila Lunguya, Jean Marie Kayembe, Hippolyte Nani Tuma Situakibanza, et al.
Context and objective. Drug-resistant tuberculosis (DR-TB) has a major impact on patient treatment outcomes. The strategies put in place for its control involve early diagnosis and appropriate treatment of patients. The objective of the present study was to determine the phenotyp…
Yani Jane Sugiri, Rezki Tantular, Silvy Amalia Falyani, Uray Riki Arif Maulana
Introduction. Mycobacterium tuberculosis (MTB) is continually evolving in order to resist treatment. This has resulted in drug-resistant tuberculosis, which has a greater rate of therapy failure and mortality, as well as the necessity for other ways of disease transmission preven…
Pallavi Zode, Vinod Thakre
The deadly infection known as tuberculosis (TB), It is caused by the germs Mycobacterium tuberculosis, is quite difficult for humans to treat. For the treatment of tuberculosis, more than twenty allopathic medications are used. All of the drugs have side effects, including hepati…
Anna Griego, Beatrice Antinori, Andrea Spitaleri, Ilaria Muzzolini, Stefano Muzzioli, et al.
… So far it is thanks to antibiotics that illnesses, such as Tuberculosis (TB), are treatable. However, antimicrobial misuse combined with Mycobacterium tuberculosis phenotypic plasticity are nullifying the effects of the existing therapies. As a result, increasingly people are dy…
Anita Basavaraj, Naveen Kannur
… Tasgaon, Maharashtra who was diagnosed with drug resistant tuberculosis affecting his lungs and brain, resistant to first line antitubercular drug Rifampicin. Initially he was diagnosed as a case of extrapulmonary tuberculosis, left sided tubercular pleural effusion. Later durin…
W.R. Bishai, H. Guo, W.S. Weiner, C. Maddox, S. Lun, et al.
…effectiveness of β-lactam antibiotics against Mycobacterium tuberculosis has hindered the utility of this compound class for tuberculosis treatment. However, the results of treatment with a second-line regimen containing meropenem plus a β-lactamase inhibitor were found to be enc…
Oki Nugraha Putra, Telly Purnamasari
…ndonesia is one of the countries with the highest burden of tuberculosis and drug-resistant tuberculosis (DR-TB) across the world. Based on data from the World Health Organization (WHO) Global TB Report 2023, it is estimated that there are 10000 cases of DR-TB in Indonesia. Bedaq…
Anusha Gopinathan, Shweta Sagar Naik, K.V. Leela, Sujith Ravi
Tuberculosis, commonly called as TB is a fatal infectious disease caused by the bacteria, Mycobacterium tuberculosis . The presence of multidrug resistant and extensively drug-resistant M. tuberculosis in India shows the true state of affairs in our country, despite there being w…
Francesca M Conradie
BEAT Tuberculosis is a phase 3, open label, multi-centre, randomized controlled trial. The purpose of this trial is to compare the efficacy and safety of a Study Strategy consisting of 6 months of bedaquiline (BDQ), delamanid (DLM), and linezolid (LNZ), with levofloxacin (LVX) an…
Janssen Infectious Diseases BVBA Clinical Trial
…ts with pulmonary infection due to strains of Mycobacterium tuberculosis (M. tuberculosis) with resistance to isoniazid (INH), rifampin (RMP), and to a fluoroquinolone (FQ) and/or injectable second line tuberculosis (TB) drug (kanamycin, amikacin, or capreomycin) and who are unab…
Natália Rocha Almeida, Caio Azevedo Lima, Natália Lopes de Freitas, Fabiana Brandão
…(PLHIV) are at greater risk of infection and development of tuberculosis, caused by Mycobacterium tuberculosis. In Brazil, the high mortality rate is identified precisely on the occasion of coinfection and it can actively lead to severe complications. This study aimed to analyze …
Hadeel Elhashmy
Tuberculosis remains a major cause of morbidity and mortality globally, one of the causes are multidrug resistant tuberculosis (MDR-TB). MDR-TB refers to tuberculosis that is resistant to both rifampicin and isoniazid. Almost 20% of all TB strains worldwide are resistant to at le…
Yu. A. Sheifer, I. S. Gelberg, S. B. Wolf, S. N. Demidik, A. N. Aleksa
… present, despite the generally favorable pathomorphosis of tuberculosis (TB), a number of factors that have a negative impact on the epidemiological situation, clinical manifestations and treatment outcomes remain. Objective: To determine the role of aggravating factors in the d…
O. V. Filinyuk, A. S. Аlliluev, D. E. Аmichba, П. Н. Голубчиков, Yu. S. Popelo, et al.
…requency of multiple drug resistance (MDR) of mycobacterium tuberculosis (MBT) in new tuberculosis patients with the reference to their HIV status and to assess their treatment outcomes. Subjects and methods. The presented results were obtained from a retrospective cohort study o…
Ke Hao, Lihong Fan
As a chronic infectious disease, tuberculosis (TB) is closely related to immune regulation and immune effect. Immunotherapy which can improve the curative effect of tuberculosis and control the spread of tuberculosis, is one of the important means for the comprehensive treatment …
I. Zhanybekov
…inical and epidemiological characteristics of patients with tuberculosis, the causative agent of which has broad (XDR-TB) and pre-wide (pre-XDR-TB) drug resistance in the Kyrgyz Republic. The study included 89 patients, 38 of them with XDR-TB and 51 with pre-XDR-TB, who were trea…