A Case Report of Drug Resistant Tuberculosis Involving Brain

We report a 21 year old male resident of Tasgaon, Maharashtra who was diagnosed with drug resistant tuberculosis affecting his lungs and brain, resistant to first line antitubercular drug Rifampicin. Initially he was diagnosed as a case of extrapulmonary tuberculosis, left sided tubercular pleural effusion. Later during course of treatment he developed central nervous system tuberculosis confirmed on magnetic resonance imaging brain contrast study and Cerebrospinal fluid study. Cerebrospinal fluid catridge based nucleic acid amplification test showed Rifampicin resistance. He was started on Modified longer oral Multidrug/extensively drug resistant tuberculosis regimen according to Programmatic management of drug resistant tuberculosis in India, 2021 guidelines. Keywords: Tuberculosis, Extra pulmonary, Programmatic management of drug resistance, Oral regimen, Central nervous system tuberculosis