Showing 151–175 of 200 documents
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Salma Hameed, Nasir Mahmood, Muhammad Nawaz Chaudhry, Ahmad, Mohammad Aqeel ur Rahman, et al.
…reated-TB patients and risk factors associated in spread of tuberculosis are investigated in the current study. A total 244 Mycobacterium tuberculosis isolates were used for drug-susceptibility test against four drugs. Environmental risk factors were assessed by using self-design…
Khosravi AD, M Sirous, Zahra Absalan, Tabandeh MR, Mohammad Savari
…und: Among different resistance mechanisms in Mycobacterium tuberculosis (MTB), efflux pumps may have a role in drug-resistance property of MTB. So, the aim of this study was to compare the relative overexpression of two important efflux pump genes, drrA and drrB, among MTB isola…
G. V. Zodape, SujataN Dharmashale, V. S. Gaikwad
…cid (PAS), ethanolic extracts of P. nigrum on Mycobacterium tuberculosis (MTB) strain H37Rv and Multi drug-resistant (MDR)-strains-12, 19 and 21. The proportion method was used to detect the anti-mycobacterial drug susceptibility testing for mycobacteria using Lowenstein Jensen (…
Н. Е. Евдокимова, S.P. Zorina, M. S. Kornilov, С. Н. Кондаков, E.S. Prokopyev, et al.
…tant (MDR) pulmonary TB caused by different genotypes of M. tuberculosis in the Sakha Republic (Yakutia). Materials and methods. We carried out a retrospective analysis of treatment outcomes in 107 patients with newly diagnosed microbiologically confirmed MDR TB. M. tuberculosis …
Yusup Subagio Sutanto, Magdalena Sutanto, Agnes Sri Harti
… Covid-19 pandemic on the resistance level of Mycobacterium tuberculosis (MTb) isolates to Anti Tuberculosis Drugs (ATD) needs to be carried out considering the level of MTB resistance is an important factor in the occurrence of Multidrug-Resistant TB (MDR-TB) in Indonesia. The p…
Omar Rashid, Anjum Farhana, Nargis Bali, Maroof Peer, Roseleen Kour, et al.
…detection and drug susceptibility analysis of Mycobacterium tuberculosis (MTB) in the shortest possible time has been the driving force for research that aims to bridge the gap between detection and treatment. In this regard Line Probe Assays (LPA) were commissioned in 2008 by Wo…
Reena Ughreja, Vaibhav Bhatt, Sunny Shah, Devang Boxa
Background: Mycobacterium tuberculosis causes tuberculosis (TB), the most lethal infectious disease in the world that affects people of all ages. The aim of our study was to estimate the prevalence of TB in the Gujarat state (India). \nMaterial and methods: This was a retrosp…
World Health Organization
…r pretomanid and cycloserine drug susceptibility testing in tuberculosis (TB). The document addresses a major gap in the laboratory diagnosis and management of drug-resistant TB, given the increasing use of pretomanid-containing regimens and the absence of WHO-endorsed phenotypic…
Anam Shafiq, Hidayat Khan, Mohammad Shahid, Nazish Fatima, Mo Ahamad Khan
The global tuberculosis (TB) epidemic is becoming progressively more complex due to the increasing prevalence of multidrug-resistant TB (MDR-TB), particularly with resistance to fluoroquinolones (FQs). This study focuses on identifying genetic mutations in the gyrA and gyrB genes…
Weiwei Gao, Nan Yang, Xiaomin Mei, Xiaojing Zhu, Weiyi Hu, et al.
…f this investigation was to determine the influence of anti-tuberculosis (anti-TB) drugs plus cycloserine (CS) on the sputum negative conversion rate, adverse reactions and inflammatory factors in the treatment of multidrug-resistant tuberculosis (MDR-TB). METHODS: Seventy patien…
Andi Sitti Nur Afiah, Fera The
Tuberculosis (TB) is a pulmonary disease caused by Mycobacterium tuberculosis. Globally in 2018 theestimated number of people affected by TB was estimated at 10.0 million population and 484,000 cases ofmultidrug-resistant TB (MDR-TB). This study aims to determine the correlation …
Kang-Mo Gu, Sun‐Young Jung, Jae-Eun Lee, Joo-Hyeon Eom, Kyungeun Lee, et al.
…idence rate of rifampin-resistant TB (RR-TB). The effect of tuberculosis (TB) preventive treatment (TPT) on household contacts (HHC) of RR-TB in an intermediate TB burden country has not been well evaluated. Study Design and Methods: This retrospective cohort study analyzed …
Thushara Balakrishnan, N Girish
Background and Aims The emergence of multi drug-resistant tuberculosis MDR-TB in treatment naiumlve Pulmonary Tuberculosis PTB is an epidemiological indicator indicating transmission of drug-resistant strains in the community. This study aimed to assess the patterns of drug resis…
Meenakshi Dey, Suhani Jain, Ira Shah
…hydrocephalus.1 We present a patient of multidrug-resistant tuberculosis (TB) peritonitis due to seeding of tuberculous bacilli through VP shunt from multidrug-resistant tuberculous meningitis. A 4.5-year-old male presented in December 2018 with fever and vomiting since 1 week. O…
Priya Rathi, Kalpita Shringarpure, Bhaskaran Unnikrishnan, Abhinav Pandey, Abhirami Nair
…round</ns3:bold> : Delays in initiating multidrug-resistant tuberculosis (MDR TB) treatment adds risk to individual patients and the community due to disease progression, and on-going transmission. The Government of India offers free TB diagnosis and treatment, however many presu…
Arastu Sharma, Rakesh Jain
…itate diagnosis for simultaneous detection of Mycobacterium tuberculosis and its resistance to first-line anti-tuberculosis drugs (Isoniazid and Rifampicim) are designed for lab-based settings and are unaffordable for large scale testing implementations. The suitability of a TB d…
Priya Rathi, Kalpita Shringarpure, Bhaskaran Unnikrishnan, Abhinav Pandey, Abhirami Nair
…round</ns3:bold> : Delays in initiating multidrug-resistant tuberculosis (MDR TB) treatment adds risk to individual patients and the community due to disease progression, and on-going transmission. The Government of India offers free TB diagnosis and treatment, however many presu…
Yusup Subagio Sutanto, Magdalena Sutanto, Agnes Sri Harti
… Covid-19 pandemic on the resistance level of Mycobacterium tuberculosis (MTb) isolates to Anti Tuberculosis Drugs (ATD) needs to be carried out considering the level of MTB resistance is an important factor in the occurrence of Multidrug-Resistant TB (MDR-TB) in Indonesia. The p…
Jing Liu, Meiying Wu, Jing Lu, L Zeng, Cuilin Shi
…rial infection, combined with multidrug-resistant pulmonary tuberculosis and bronchial tuberculosis. In this case report, we focused on the clinical presentation and CT imaging features of SPE, and the application value of mNGS. This case study suggests that CT combined with mNGS…
World Health Organization
…his web annex examines commonly observed problems affecting tuberculosis (TB) surveillance systems and presents proposed solutions based on findings from WHO-supported epidemiological reviews conducted in multiple countries between 2013 and 2020. Prepared as part of the WHO conso…
Yasha Ektefaie, Avika Dixit, Luca Freschi, Maha Farhat
Abstract Background Mycobacterium tuberculosis (MTB) whole genome sequencing data can provide insights into temporal and geographic trends in resistance acquisition and inform public health interventions. Methods We curated a set of clinical MTB isolates with high quality sequenc…
Yusup Subagio Sutanto, Magdalena Sutanto, Agnes Sri Harti
… Covid-19 pandemic on the resistance level of Mycobacterium tuberculosis (MTb) isolates to Anti Tuberculosis Drugs (ATD) needs to be carried out considering the level of MTB resistance is an important factor in the occurrence of Multidrug-Resistant TB (MDR-TB) in Indonesia. The p…
Rujittika Mungmunpuntipantip, Viroj Wiwanitkit
…blic health issue facing the world today is still pulmonary tuberculosis (TB). Several regions of the world continue to be plagued by the disease. Multidrug-resistant TB is the issue that needs to be prioritized in Indochina because it is still a problem there. The local policy c…
Vasile Popa, Carmina Paladi, Marina Stanceva, Alina Malic, Evelina Lesnic
…nd microbiological peculiarities of patients diagnosed with tuberculosis. Material and methods: an analytical and retrospective study, which included 380 new cases of tuberculosis diagnosed in 2020 was performed. Results: the particularities of the patients were male sex, age bet…
Emeli Paul Choudhury, Kamalesh Sarkar, Umesh Chandra Ojha
Introduction: Tuberculosis (TB) patients often incur huge costs due to TB care and the cost is even higher when it’s an MDR-TB treatment. Despite free TB treatment under the Revised National Tuberculosis Control Program (RNTCP), the indirect cost borne by the patients due to th…