Showing 151–175 of 196 documents
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Worku Nigussa, MD
… clinical decision-making. Since its endorsement by the WHO guidelines in 2010, Xpert MTB/RIF (Cepheid, CA, USA), a molecular test that can detect mycobacterial DNA and genetic polymorphisms associated with rifampicin resistance, has entered into diagnostic workup in both high- a…
Andreas W. Bub, Henry Beecher, Elgida R. Volpicelli, Forugh Homayounrooz, Grecia Alvarez
Introduction: Biologic therapies have revolutionized the treatment of patients with inflammatory bowel disease (IBD) and Anti-TNFa inhibitors are the most commonly used agents for patients with moderate to severe disease. Prior to initiation, patients are checked for Tuberculosis…
Senia Rosales-Klintz, Judith Bruchfeld, Walter Haas, Einar Heldal, Rein M G J Houben, et al.
…e for TB elimination [3]. To this end, timely detection and treatment of latent tuberculosis infection (LTBI) is an important intervention [3]. Currently, the existence and implementation of national strategies including public health interventions targeting LTBI is heterogeneous…
José Kadima, Pascal Lutumba, Michel Kaswa, Vivi Maketa, Junior Matangila, et al.
…n in the incidence rate between 2015 and 2035. The 2018 WHO guidelines recognize the need for high-burden countries to implement outreach and treatment for the most vulnerable patients with latent TB infection (LTBI) in addition to treating patients with the active disease. The D…
Roslin Jose, Suchit Thapa Chhetri, Eleena Dhakal, Erica L. Stockbridge, Miller, Thaddeus
…d 80% of active TB cases in the US are from reactivation of latent TB infection (LTBI). Reactivation is preventable with proactive, targeted LTBI screening and treatment but public health agencies lack the capacity to mitigate this threat. Recent guidelines recommend that LTBI-re…
Huashan Hospital
…-endemic areas. The pregnancy rate of assisted reproductive treatment (ART) in the infertile women with FGTB is still unsatisfied even after receiving standard anti-tuberculosis treatment. Moreover, recent years have witnessed an alarming increase in reports of FGTB-related mater…
Cassidy Boomsma, Tine Vindenes
…worldwide. Most active TB cases result from reactivation of latent tuberculosis infection (LTBI). A large reservoir of latent TB is a major public health problem worldwide and in the United States. A better understanding of provider perspectives on LTBI could improve a sub-optima…
David SC Hui, MD
…st in rheumatologic disease patients prior to initiation of treatment with biologic and/or targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARD). This is a prospective observational study involving the recruitment of patients with rheumatologic diseases who are pla…
KN Malu, AR Lamb
…n important first line drug in the management of active and latent TB. Its widespread use and lack of diagnostic testing has resulted in an increase in the prevalence of Hr-TB, either alone or in combination with other drugs. katG and inhA mutations confer high and low level INH …
Biswajit Chakraborty, Amaj Laskar, Anamika Baruah, Remesh Kumar, Mustafa A. Barbhuiya
…25. Despite the efforts, practice gaps remain in diagnosis, treatment, and monitoring. Accelerated strategies focusing on early detection, management of latent TB, and control of drug resistance are critical. This review explores global guidelines, highlights implementation chall…
Sofia Kostoudi, Robert Hammond
…er COVID-19 and the 13 th leading cause of death worldwide. Latent tuberculosis (LTBI) has become a major pool of potential active tuberculosis cases and is propelling the TB global health burden further. Objective The creation and application of a diagnostic to effectively ident…
Niamh Kearney, Fawad Aslam, Grace Boyd, Natasha Boylan, Emma Laverty, et al.
…ssociation of Dermatologists (BAD) 2020 psoriasis biologics guidelines recommend routine screening for latent tuberculosis infection (LTBI) prior to treatment, using a QuantiFERON®/interferon-gamma-releasing assay (IGRA), with consideration of local policy on additional screening…
Enrique G. Villarreal, Ricardo J. Estrada-Mendizábal, Emilia Ramos-Barrera, Pablo D Treviño-Valdez, Oscar Tamez‐Rivera
…million children develop TB disease and many more present a latent form of infection. The objective of this study is to define the epidemiological trends of the different clinical presentations of TB in pediatric population. Methods A retrospective, cross-sectional study, carried…
Sanghmitra Singh, Geetu Singh, Himalaya Singh, Gajendra Vikram Singh
… Preventive Therapy (TPT) is a critical strategy to prevent latent TB infection (LTBI) from progressing to active disease, particularly among household contacts (HHCs) of pulmonary TB patients. Objective: This study evaluates the completion rate and factors influencing TPT adhere…
Guilherme Santoro‐Lopes, Wanessa Trindade Clemente
…munity exposure after transplantation, or reactivation of a latent tuberculosis infection (LTBI). This latter accounts for the majority of TB cases, especially in countries with low TB prevalence.4 The detrimental impact of TB on patient outcomes underscores the critical importan…
Hamidah Hussain, Amyn A. Malik
…Systematic Review, meta-analysis, and cost-effectiveness of treatment of latent tuberculosis to reduce progression to multidrug-resistant tuberculosis.Clin Infect Dis. 2017; 64: 1670-1677Crossref PubMed Scopus (88) Google Scholar, 2Seddon JA Fred D Amanullah F et al.Post-exposure…
Robert I. Anderson, Eleanor Sheppard, Jun Yong, Alastair Yeoh, Thomas Seddon, et al.
…tion and management requires multi-disciplinary approach. • Latent TB screening in haematological malignancy is challenging. • Better evidence-based risk-stratification screening tools are needed. Current data indicate a rising incidence of tuberculosis in the UK, affecting both …
Eun Hye Lee, Ji Soo Choi, Chang Hwan Seol, Byung Hoon Park, Moo Suk Park, et al.
…sis (TB) infection due to their occupational exposure. Many guidelines recommended to perform routine screening for latent tuberculosis infection (LTBI) of HCWs to receive appropriate treatment. This study aimed to identify the risk factors of positive interferon-gamma (IFN-γ) re…
Ebru Evren, Merve Gürler, Ayşe Hande Türk, Ebru Us, Zeynep Ceren Karahan
…nocompromised individuals, accurate and timely diagnosis of latent TB (LTB) and active TB (ATB) has gained great importance. The aim of this study was to investigate the rationale lying behind interferon gamma release assay (IGRA) requests for patients applying to various clinics…
Carolyn J. Sachs
…/sup> After testing positive an employee is assumed to have Latent Tuberculosis (LTB) per CDC guidelines and must submit to antimicrobial therapy or more invasive radiologic testing as a condition of continued employment. In 2011 the employer ceases to permit new employees or tho…
M.G. Mustapha, Garba Mohammed Ashir, AI Rabasa, Asmaa Farouk, Hassan Abdullahi Elechi, et al.
…iated with poor uptake of preventive therapy for those with latent infection, contacts and people living with HIV and AIDS (PLWHA) in most developing countries.While significant similarities exist between spectrum of TB occurring in adults and children, the characteristics and pe…
J P Le, N Gupta, O Ahmed, P Zafar, R Gul, et al.
…, diabetes, lymphopenia, or immunosuppression. ATS/IDSA/CDC guidelines emphasize that IGRAs and TSTs are not diagnostic for active TB—they do not distinguish latent infection from disease and should not exclude TB when suspicion remains high. The combination of epidemiologic risk…
Saadiq Garba, Heidi Fischer, Lei Qian, Zhuoxin Li, Katia Bruxvoort, et al.
… US; more than 2 million Californians are estimated to have latent tuberculosis infection (LTBI), and 87% of TB cases in 2021 were attributed to LTBI reactivation. This study in a large California health system assessed missed opportunities for LTBI screening and treatment among …
Jay A. Fishman
…us challenge worldwide, notably in immunocompromised hosts. Guidelines for management exist.1Bumbacea D Arend SM Eyuboglu F et al.The risk of tuberculosis in transplant candidates and recipients: a TBNET consensus statement.Eur Respir J. 2012; 40: 990-1013Crossref PubMed Scopus (…
Prashant Kumar, Akhilesh Kumar, Rahul Raj
…E, 72 publications underwent an examination adhering to the guidelines outlined in the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). The comprehensive approach included diverse languages and study settings, providing a thorough understanding of TBI …