Showing 151–175 of 200 documents
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О.С. Шевченко, L.D. Todoriko, R.S. Shevchenko, S.L. Matvyeyeva, І.А. Овчаренко, et al.
…defensin-1, ferritin and Interleukin-6 and the spectrum of drug resistance, as well as the treatment regimens in patients with pulmonary tuberculosis. Materials and methods. This study included 100 patients with pulmonary tuberculosis, divided into two groups: Group 1 (n = 52) w…
Kasimu Mamuda, Aliyu Sani, Steven Olonitola, Opaluwa Saraja
…tious diseases that cause death worldwide; the emergence of drug resistant mycobacterium tuberculosis is of great concern for TB control programme in Nigeria. Aim and objective: To detect multi-drug and extensively drug resistant mycobacterium tuberculosis among tuberculosis pati…
Sakshita Agnihotri, Kuldeep Yadav
Objective: Resistance against Mycobacterium tuberculosis (MTB) is important in the sense that it has an implication in the control of tuberculosis. The terms used to describe resistance to antituberculosis drugs are resistance among new cases (or primary resistance) and resistanc…
Nathan Hicks
…acy of this therapy has been undermined by the evolution of drug resistant Mtb strains, which are able to grow in the presence of clinically utilized antibiotics. The chromosomal mutations that cause drug resistance in Mtb have largely been identified, allowing for rapid genotype…
Min Gao, Tianchi Yang, G L Li, R Chen, Hung-Chi Liu, et al.
The results showed the main mutation types of resistance-related genes of MDR strains to many commonly used anti-tuberculosis drugs in China based on whole-genome sequencing, providing a basis for the development of sensitive and specific rapid molecular detection methods. At the…
Dana Auganova, Aygulya Akisheva, Anna Tsepke, Pavel Tarlykov
…osis mortality has risen in comparison with previous years. Drug resistance is another threatening issue when the resistance to antitubercular (anti-TB) drugs makes therapy less effective. Furthermore, drug resistance is often burdened with compensatory mechanisms that overcome f…
Supriya Dhakne
Introduction: Multidrug‑resistant tuberculosis (MDR‑TB) has created a significant health problem in most of the countries, and it is an obstacle to effective TB control. Aims and Objectives: The study aims to study the prevalence of MDR‑TB among new cases, retreatment cases and t…
Harun Patel, Iqrar Ahmad, Harsha Jadhav, Rahul Pawara, Anand B. Mundada, et al.
…(TB) management remains challenging due to the emergence of drug-resistant tuberculosis such as MDR-TB and XDR-TB. To improvise therapeutic results for MDR/XDR-TB, 89 nations had started utilizing bedaquiline and 54 had utilized delamanid by June 2017. Unfortunately, cardiac arrh…
Sushil Giri, Kailash Chandra Semwal, Shruti Agarwal, Gautam Singh Bhandari, Amit Kumar, et al.
Acquiring of the resistance to the variant line of the drugs used in drug therapy for M. tuberculosis is becoming a crucial problem for the entire globe. Mutation in cord factor led to the bacterium resistant against antibiotics therapy. These changes drive the chromosomal mutati…
Lindiwe Modest Faye, Carine Bokop, Sandeep Vasaikar, Teke Apalata, Ntandazo Dlatu
…he fight against such illnesses has led to the emergence of drug-resistant infectious diseases, which have become increasingly dif-ficult to manage as medical and scientific research has advanced. Inadequate medical infrastruc-ture, incorrect treatment practices that exacerbate r…
Justin Ginting, Katharina Ellen Dominika, Ardo Sanjaya, Julia Windi Gunadi
…at causes the infectious disease tuberculosis. Based on its resistance, tuberculosis can be divided into Drug-susceptible Tuberculosis (DS-TB) and Drug-resistant Tuberculosis (DR-TB). MDR-TB is one type of DR-TB when M. tuberculosis complex strains unresponsive to rifampicin and …
Suranga Manilgama
Multi-drug resistant tuberculosis (MDR-TB), resistant to rifampicin and isoniazid, is more common in individuals previously treated for tuberculosis. The main cause of MDR-TB is transmission rather than de novo resistance during treatment. TB strains lacking catalase are typicall…
Arti D. Shah1 , Anchal Jain2 , Apoorva3 , Kusum V. Shah4 , Yash Rana5 , Saket kumar6
Drug resistant tuberculosis is a major public health concern in many countries including India, Isoniazidresistance (INH) accounts for 7.2 % of new cases globally.1In our case series 3 patients had INH monoresistance out of which 2 patients had no previous history anti tuberculos…
О.С. Шевченко, О.О. Pohorielova
Background. Multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis remain severe epidemic problems in the world. That’s why the purpose of our study was to investigate the dynamics of the incidence of multidrug-resistant and extensively drug-resistant tuberc…
Muhammad Sani Aliyu, Issa Garba, M. B. Tijjani, Mhi Doko, Mukhtar, G. L., et al.
This study characterized multi-drug resistant M. tuberculosis phenotypically by LJ-proportion method and genotypically by GenoType MTBDRplus LPA. Out of the forty M. tuberculosis isolates tested, two (5.0%) were found to be multi-drug resistant by the LJ proportion method, and on…
Naoufal Sirri, Christophe Guyeux, Christophe Sola
…ains a significant public health issue, and addressing multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains is a critical global health priority. Resistance primarily results from mutations in genes related to drug targets or enzyme conversions, though our under…
Mehdi Roshdi Maleki
…ublic neglect and the ability of M. tuberculosis to develop drug resistance have led to the emergence of multidrug-resistant, extensively drug-resistant, and totally drug-resistant strains. These resistances are mainly caused by genetic mutations in antibiotic target genes, which…
Salam El Achkar
…, with 10 million new cases estimated worldwide in 2017. TB drug resistance and its diagnosis are particularly problematic. Only 25% of the 450,000 incident multidrug resistant (MDR) TB patients estimated over the same year were diagnosed and treated as such.Although Lebanon is a…
Rida Masood, Iyad Naeem Muhammad, Tuba Siddiqui, Madiha Mushtaque, Asma Irshad
…ort 2018, Pakistan is amongst the 30 countries high TB with drug-resistant Mycobacterium tuberculosis particularly MDR (multi-drug resistant strains). A retrospective study had been designed using DR-TB patients' records from January 2013 to the December 2017 year from a public s…
Josephine Amie Koroma, Mariama Mahmoud, Bailah Molleh, Stephen Sevalie, Adrienne K. Chan, et al.
…eone are missing each year. Challenges with notification of drug-susceptible TB can result in drug-resistant TB. The COVID-19 pandemic has further compounded these challenges, resulting in increased drug-resistant TB cases and poor treatment outcomes. This study highlights the ef…
Wan-mei Song, Jing-yue Liu, Qi Fu, Tingting Xu, Shi-jin Li, et al.
Abstract Background: Finding out more predictors of drug-resistant tuberculosis (DR-TB) helps to facilitate TB prevention and control. Previous study had revealed that tobacco smoking and alcohol drinking might be a risk factor for developing drug-resistant tuberculosis. However,…
Akansha Goyal, Hiral Gadhavi, Binita Aring, Summaiya Mullan
… an early diagnosis followed by the rapid identification of drug resistance, in order to treat patients adequately, break the chain of transmission, and avoid the spread of resistant strains. Multidrug-resistant (MDR) Mycobacterium tuberculosis have emerged worldwide and seriousl…
Kassa GM, Merid MW, Muluneh AG
…l goshuatalay12@gmail.comBackground: Rifampicin and/or multidrug-resistant tuberculosis (RR/MDR-TB) remains an uncontrolled public health emergency that has been synergized by the recently increased person-to-person transmission in the community as primary RR/MDR-TB, which is def…
Gina Oda, Cynthia Lucero‐Obusan, Patricia Schirmer, Mark Holodniy
…8, the CDC reported that isoniazid (INH)-resistant and multidrug-resistant Mycobacterium tuberculosis (MDR-TB, ie, resistant to at least INH and rifampin) represented 9.3% and 1.5% of TB cases, respectively, in the United States. Objective: We analyzed the prevalence of drug-resi…
Faeez Muhammad, Laiba Siddiqui, Rabbia Gul
… intercept the proliferation of the disease. In the case of drug- resistant TB, failure to detect the resistance of anti TB drugs may give rise to extensively drug- resistant tuberculosis (XDR-TB). Thus, the rapid detection of drug resistance is vital;, however, the current stand…