Showing 126–150 of 200 documents
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Tianyin Wang, Darla Quijada, Taha Ahmenda, Jennie Ruelas Castillo, Nour Sabiha Naji, et al.
Abstract Tuberculosis (TB) remains among the leading infectious causes of death. Due to the limited number of antimicrobials in the TB drug discovery pipeline, interest has developed in host-directed approaches to improve TB treatment outcomes. C-C motif chemokine-like receptor 2…
Xiaolin Wei, Joseph Paul Hicks, Zhitong Zhang, Victoria Haldane, Pande Pasang, et al.
…mmended to complement directly observed treatment (DOT) for tuberculosis (TB) but without conclusive evidence. We conducted this pragmatic, superiority trial in six counties in Shigatse, Tibet. Eligible participants were drug-susceptible TB patients aged ≥15 years starting standa…
Gustavo Amorim, David W. Haas, Marcelo Cordeiro‐Santos, Afrânio Lineu Kritski, Marina C. Figueiredo, et al.
Background: Therapeutic drug ranges (TDR) for standard anti-tuberculosis (TB) treatment have been determined based on expected drug levels at least 2 hours after taking the dose. In this study we constructed TDR for TB drug levels based on minimizing drug toxicity and maximizing …
Grace Kansiime, Abinet M. Aklilu, Joseph Baruch Baluku, Farah Yasmin, Michael Kanyesigye, et al.
…s AKI is thought to be a rare complication in patients with tuberculosis (TB) infection and is mostly attributed to TB drugs. Our findings show AKI occurs more often than previously thought and approximately 33% of patients with drug-susceptible TB may have kidney dysfunction. Ac…
Alphonce Liyoyo, Hamu J. Mlyuka, Iris Spelier, Jodie A. Schildkraut, Julie Anderson, et al.
…ning and capacity by growing the workforce of scientists in tuberculosis (TB) endemic settings skilled in “development and rapid uptake of new TB tools and “interventions” and “research to optimise implementation and impact”. The SimpliciTB consortium aimed to develop the skills,…
Flávia M. Sant ́Anna, Mariana Araújo‐Pereira, Carolina Arana Stanis Schmaltz, María B. Arriaga, Raquel de Vasconcellos Carvalhães de Oliveira, et al.
Standard anti-tuberculosis treatment is highly effective, but a great challenge is the management of adverse drug reactions (ADR). Our study aimed to characterize ADR according to type, severity and time of occurrence. A prospective tuberculosis (TB) cohort has been followed, fro…
Ramnath Subbaraman, Beena Thomas, J Vignesh Kumar, Kannan Thiruvengadam, Amit Khandewale, et al.
Abstract Background Suboptimal adherence to tuberculosis (TB) treatment is associated with increased disease recurrence and death. Little research has been conducted in India to understand TB medication non-adherence. Methods We enrolled adult drug-susceptible TB patients, about …
Dmytro O. Butov, Tetyanas S Butova
…atients with new sputum positive drug-susceptible pulmonary tuberculosis (TB) with tuberculous meningoencephalitis (TM) and human immunodeficiency virus (HIV) co-infection in the intensive phase of treatment. Methods: Fifty-four patients with TB / TM and HIV co-infection were enr…
Marcela Muñóz-Torrico, Norma A. Téllez-Navarrete, Heinke Kunst, Linh Nguyen
The main goals of this chapter are to establish tuberculosis (TB) treatment goals, how and when to start anti-TB treatment, discuss the recommended regimens for drug sensitive TB. Establish recommended doses of the primary regimen, and finally recommended treatment adjustment in …
Olanrewaju Oladimeji, Victor Abiola Adepoju, Felix Emeka Anyiam, James Emmanuel San, Babatunde A. Odugbemi, et al.
<strong>Abstract<br> Objective: </strong>The Lagos State Tuberculosis, Buruli Ulcer, and Leprosy Control Program<br> (LSTBLCP) started engaging private hospitals under the Public-Private Mix (PPM)<br> Program in 2008. The study aimed to evaluate the trend and predictors of succes…
L.V. Natrus, L.V. Gayova, O. A. Gorkunenko, P.A. Chernovol, M.V. Zelinska
…thods. The study involved 47 patients with drug-susceptible tuberculosis first time discovered. 58 healthy volunteers comprised a control group. Laboratory indices were determined in venous blood three times: before the treatment as baseline; in 2 months of intensive therapy (iso…
Rida Masood, Naeem Muhammad Iyad, Kanwal Ali Sidra, Mushtaque Madiha, Siddiqui Tuba, et al.
…tify the increasing number of morbidity of drug susceptible tuberculosis (TB) and its treatment outcomes, government cost of medicines as well as the economic impact on society. A retrospective observational study had been conducted in a government hospital using a patient’…
Peter Okpeh Amede, Elizabeth Adedire, Aishat Bukola Usman, Celestine Ameh, Faruk Saleh Umar, et al.
<title>Abstract</title> Background: Tuberculosis (TB) is a contagious disease and its transmissibility potential is increased in congregate settings like the prisons. TB incidence rates are five to fifty times higher among prison inmates than the general population which has a di…
Lina Davies Forsman, MD, PhD
…estions: In adult patients with drug-susceptible pulmonary tuberculosis, can current dose recommendations and information received from MIPD help clinicians in a timely manner to optimise the drug exposure of TB drugs in the early treatment phase, i.e., the time from PK sampling…
Linda prof
…nosed, bacteriologically confirmed drug-sensitive pulmonary tuberculosis. The main questions it aims to answers are: * Does adjunct n-3 LCPUFA supplementation reduce the sputum culture time to positivity * Does it improve inflammatory markers and TB treatment outcomes compared …
Radojka Savic, PharmD, PhD, Kelly Dooley, MD, PhD, Gustavo Velásquez, MD, MPH
…for the treatment of adults with drug-susceptible pulmonary tuberculosis (TB). A5409 hypothesizes that novel regimens for the treatment of pulmonary tuberculosis will result in superior early efficacy, as determined by longitudinal mycobacteria growth indicator tube (MGIT) liqui…
Sohag University
Tuberculosis is a major cause of ill health and one of the leading causes of death worldwide. Early, rapid and accurate diagnosis of all TB patients and prompt treatment with any form of drug-susceptible or drug resistant TB is fundamental. Identifying the pattern of drug resista…
Katarina Niward, MD, PhD
Tuberculosis (TB) treatment is long and complex with the risk of poor treatment adherence and treatment failure. Several attempts to shorten treatment of drug-susceptible TB have been unsuccessful. However, recent data support a shortened regimen for mild and moderate pulmonary T…
Shenjie Tang, MD
…r newly diagnosed smear positive drug susceptible pulmonary tuberculosis in comparison to World Health Organization recommended standard 6-month regimen. 1. Design: The study is a multi-center, randomized,controlled non-inferiority trial. 2. Population: patients with newly diagn…
Л.Д. Тодоріко, О.V. Pidverbetska
…ncy of malabsorption in newly diagnosed sensitive pulmonary tuberculosis (TB) and to establish the effectiveness of treatment correction in these patients. MATERIALS AND METHODS. In the first stage of the study, 73 patients with new drug-susceptible TB underwent lactulose-mannito…
Michael Marll, Lungile Gabuza, Floyd B. Willis, Ana Angélica Rêgo de Queiroz, A. Rajaratnam, et al.
…prevalence and risk factors associated with PH in pulmonary tuberculosis (PTB) remain poorly characterized. This study aims to test the hypothesis that the radiographic severity of lung injury and burden of fibrocavitary disease at the time of PTB diagnosis will be associated wit…
Ying Li, Zhenzhou Feng, Linlin Song, S. Feng, Z. Wenhong
…cin has been conditionally recommended for drug-susceptible tuberculosis (DS-TB). However, concerns have arisen regarding the pill burden and safety of high-dose daily rifapentine. A randomized controlled trial with an adaptive seamless design (Optimizing RIfapentine-based regime…
M Dávid, Idah Orowe, Anthony Karanja, Hillary Kipruto
Background: Drug-resistant tuberculosis (DR-TB) is a form of antimicrobial resistance that is difficult and costly to treat. It is caused by TB bacteria that are resistant to at least one of the first-line existing TB medications, resulting in fewer treatment options and increasi…
Amit Barua, Joseph Hubble, Kathryn H. Yoo, Michael Lacassagne, John P. Areno, et al.
Recurrence of Pulmonary tuberculosis (TB) after successful completion of supervised treatment may be due to relapse or reinfection. Recurrence is common with an incidence rate of 2.26 per 100 person years over a mean follow up of 2.3 years. However, it is uncommon for an immunoco…
Yvette A. De Reus, Lies ter Beek, Tjip S. van der Werf, Onno W. Akkerman
<b>Background:</b> Malnutrition is common in patients with tuberculosis (TB) and leads to negative changes in body composition, i.e. loss of muscle mass and a decrease in physical function.<sup>1,2</sup> <b>Aims and Objectives:</b> Since it is unclear how body composition and str…