Showing 126–150 of 200 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Katherine A. Thomas, Choice Okoro, Thobani Ntshiqa, Verena Damovsky, D Goldberg, et al.
Abstract Background Several tuberculosis (TB) vaccines intended for adults and adolescents are in late-stage clinical trials, but there is limited research into how a new TB vaccine would be introduced. South Africa is at the forefront of TB vaccine research, with involvement in …
Yiran Liu, Patricia A. Darrah, Mario Roederer, JoAnne L. Flynn, Robert A. Seder, et al.
Abstract Background Identifying correlates of vaccine-induced protection against tuberculosis (TB) is essential for improved vaccine development and evaluation. Prior efforts have focused on antigen-specific CD4 T cell responses measured weeks following vacination, which have rep…
Hong Zhao, Wenyi Ye, Xia Yu, Yu Shi, Jifang Sheng
…of the current routine recommendation of vaccination, three vaccines were necessary for people to be protected against the Omicron variant.
Helen McShane, MD and PhD
This study is to assesss the safety and immunogenicity of vaccine based on Modified Vaccinia Ankara (MVA) expressing the 85A antigen (from Mycobacterium. tuberculosis). This vaccine is delivered intrdermally by a needle injection in healthy volunteers. 1. This is a phase I study…
Helen McShane, MD and PhD
This is a phase I study to test the immunogenicity of a recombinant vaccine based on Modified Vaccinia Ankara (MVA) expressing the antigen 85A (from Mycobacterium tuberculosis). This vaccine is delivered intradermally by a needle injection in healthy volunteers previously vaccina…
A. Sparrow
…as used in vitro models to test the immunogenicity of novel vaccines against TB and Dengue Fever. Initially murine dendritic cells were used to model the immunogenicity of novel vaccines candidates and an array of potential adjuvants. Three vaccine candidates, Spore FP1, YC NaMa …
Vladimir Yeremeev, Galina Shepelkova, И. В. Духовлинов, V. Ya. Gergert
Since 1924, BCG vaccine is used to protect children from the most severe forms of tuberculosis. At the same time, the protective effect of BCG in adults is variable. The potential for revaccination with live vaccine is further limited by the rapid spread of HIV infection. The ear…
Fan Jiang, Lingling Wang, Jie Wang, Peng Cheng, Jing Shen, et al.
…ics techniques in designing safe and effective tuberculosis vaccines.
Tom Sumner, Rebecca A. Clark, Christinah Mukandavire, Allison Portnoy, Chathika K. Weerasuriya, et al.
…d 300,000 cases and 55,000 deaths in 2021. New tuberculosis vaccines could play an important role in reducing this burden. Phase IIb trials have suggested efficacy of the M72/AS01 E vaccine candidate and BCG-revaccination. The potential population impact of these vaccines is unkn…
Gamaleya Research Institute of Epidemiology and Microbiology, Health Ministry of the Russian Federation
The study is aimed to evaluate the safety and immunogenicity of the medicinal product "GamTBvac" - a recombinant subunit vaccine against the tuberculosis. The study is designed as a comparative placebo-controlled study with a two-fold increase of an applied dose among healthy vol…
Hanieh Sadat Tabatabaei Yeganeh
…umented but it is likely because in their home country such vaccines are not routinely given. The number of babies who did not return for follow up was 483 (53%). These babies were followed by other centers or outside the country hence were not included in the study. The number o…
Joshua S. Woodworth, Helena Strand Clemmensen, Hannah Battey, Karin Dijkman, Thomas Lindenstrøm, et al.
…rin (BCG), it has been suggested to combine BCG and subunit vaccines for increased efficacy. Current subunit vaccines are almost exclusively designed as BCG boosters. The goal of this study was to design a subunit vaccine that does not share antigens with BCG and explore the adva…
Sam Abbott, Hannah Christensen, Ellen Brooks‐Pollock
…roaches using notification data. We estimated the number of vaccines needed to prevent a single notification, and the average annual additional notifications caused by ending the BCG schools’ scheme. Results We found a 1.9% annual decrease in TB incidence rates best matched notif…
Solomon T. Kwao, Francis T. Batsa, Samuel Na, Gaston M. Kuzamunu
Vaccination has been the only preventive mechanism of tuberculosis (TB) yet due to inconsistencies in the efficacy of the mostly used vaccine, Baccille Calmette-Guerin (BCG), re-vaccination has been deemed to be ineffective. In this work, we sought to assess the impact of age-vac…
P. V. Kulikov, С Д Жоголев, Р М Аминев, K. D. Zhogolev, А. А. Кузин, et al.
… of pneumococcal conjugate and non-conjugate polysaccharide vaccines for the prevention of community-acquired pneumonia in soldiers. Materials and methods . The incidence of communityacquired pneumonia of conscripts in the period from 2008 to 2017 was examined. PCR diagnosis of s…
Weiqi Hong, Lei Hong, Dandan Peng, Yuhe Huang, Cai He, et al.
…ovative severe acute respiratory coronavirus‐2 (SARS‐CoV‐2) vaccines that may successfully prevent various emerging emerged variants, particularly the Omicron variant and its subvariants, is necessary. Here, we designed a chimeric adenovirus‐vectored vaccine named Ad5‐Beta/Delta.…
Zachary P. Howard, Alexander Mohapatra, Weihao Zheng, J. Ernst
…protective CD4 T cell response remains the goal of most Mtb vaccines currently in testing. However, most Mtb T cell antigens do not exhibit antigenic variation, suggesting that T cell recognition does not drive selection of escape mutants. We utilized a set of antigens that do ex…
Ahmed Hussein Jasim, Amjed Hikmet Alhasnawi, Hassan Salim Aljumaily
<strong>Introduction: </strong>Tuberculosis is currently one of the planet's most serious healthy issues. Search the effect of BCG vaccine on tuberculin skin test results. <strong>Patients and methods</strong>: From January 2018 to January 2019, 1109 patients were enrolled in the…
Rebecca A. Clark, Allison Portnoy, Chathika K. Weerasuriya, Tom Sumner, Roel Bakker, et al.
…ed the benefits and costs of introducing novel tuberculosis vaccines in India overall. However, no studies have compared the potential impact of tuberculosis vaccines in regions within India with differing tuberculosis disease and infection prevalence. We used mathematical modell…
Celine Murekatete, Vinsam Owino Ouko
Introduction Tuberculosis (TB) remained a significant public health challenge globally, including in Gasabo District, Rwanda. Vaccination programs, particularly Bacille Calmette-Guérin (BCG) vaccination, played a crucial role in TB prevention. This study aimed to assess the impac…
Anne Margarita Dyrhol-Riise, PhD
…itors (COX-2i) can improve the immune system and strengthen vaccines responses. Hypothesis 1. A hyperactive COX-2/PGE2 signal system in active TB causes down-regulated immune responses that favour TB survival, but this can be abrogated by COX-2i. 2. TB-specific immunisation wit…
Kate L. Palphramand, Paul J. Anderson, Fiona Bellamy, Colin Birch, Dipesh Davé, et al.
…on do not have notable deleterious effects on either of the vaccines and that the protective effect of BCG is enhanced by booster vaccination. The protective effects afforded by both vaccines when given together, in terms of reduced disease burden or fecundity, should be determin…
Gavin Churchyard, PhD, Rasmus Mortensen, PhD
Tuberculosis (TB) is an infection caused by bacteria passed from one person to another through the air when an infected person for instance coughs, speaks, or sneezes. This study tests the safety and vaccine-induced immune response of a new preventive TB vaccine called H107e/CAF®…
Anna Kirshina, Galina Shepelkova, AS Khlebnikova, А. К. Маслов, А. И. Козлова, et al.
…viral infections motivated many researchers to develop mRNA vaccines against bacterial infections. The development of new anti-tuberculosis vaccine is an urgent task since the only approved BCG vaccine is not effective enough in terms of infection prevention, despite the fact tha…
Helen I McShane, MBBS, MRCP, BSc, PhD, Adrian VS Hill, MA, BM BCh, DPhil, DM
…the future design and modification of other T-cell inducing vaccines. Group 1 (Immune responses only) Previous human studies of MVA85A have described the immune response to vaccination at fixed timepoints but not in between. The investigators will vaccinate four volunteers and …