Showing 126–150 of 200 documents
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Wenhong Zhang, PhD
The purpose of this study is to assess the efficacy, safety and tolerability of a combination of bedaquiline, linezolid, cycloserine, clofazimine and pyrazinamide treatments guided by PZA sensitivity for 24 to 36 weeks in subjects with fluoroquinolone-resistant MDR-TB . The TB-T…
Shaojun Zhang, Yang Yan, Wenwen Sun, Zhong-Shun Zhang, Heping Xiao, et al.
…s and safety of bedaquiline-containing and bedaquiline-free regimens for treatment of patients with refractory rifampicin-resistant/multidrug-resistant tuberculosis (RR/MDR-TB). Methods: Patients with refractory RR/MDR-TB receiving bedaquiline-containing regimens (bedaquiline gro…
Natalia Yatskevich, Henadz Hurevich, Varvara Solodovnikova, E Garsevanidze, Nathalie Lachenal, et al.
… 2022 was 18-20 months. The efficacy of treatment with such regimens is low, with the WHO’s Global TB Report suggesting that efficacy was around 73% in Belarus in 2018. The development of effective short regimens for RR-TB treatment is urgent. In Belarus, six-month long treatment…
Sophia B. Georghiou, Margaretha de Vos, Kavindhran Velen, Paolo Miotto, Rebecca E. Colman, et al.
…ber of novel and repurposed anti-tuberculosis compounds and regimens, there remains a large number of drugs for which no rapid and accurate molecular diagnostic option exists. The lack of rapid drug susceptibility testing for linezolid, bedaquiline, clofazimine, the nitroimidazol…
Camilo A. Ruiz-Bedoya, Filipa Mota, Elizabeth W. Tucker, Farina J. Mahmud, Clara Erice, et al.
…atment in animals receiving high- or standard-dose rifampin regimens (Fig. 3). Whole-brain PET and immunolabeling demonstrated spatially compartmentalized inflammation, vascular leak and rifampin exposures (Fig. 4). Longitudinal imaging in the same animals showed a 40% decrease i…
Silviа Borisova, Н. Б. Бородина
…tered concurrently with antiretroviral therapy in treatment regimens for patients with such comorbidities as HIV infection and multiple drug resistant and extensively drug resistant tuberculosis. Subjects and Methods. Effectiveness and safety of chemotherapy regimens containing b…
Beijing Chest Hospital
The goal of this clinical trial is to compare the efficacy and safety of a Contezolid and Delamanid-Containing short regimen to standard longer regimen in Rifampicin-resistant pulmonary tuberculosis (RR-TB). The main questions it aims to answer are: * Is the efficacy of short re…
Soumya Swaminathan, MD, PR Narayanan, PhD
…icacy of two different once daily anti-retroviral treatment regimens along with anti-tuberculosis treatment in patients with HIV-1 and tuberculosis - Randomized Controlled Clinical Trial Phase: Phase III trial Population: 180 HIV-1 positive patients with tuberculosis Number of…
Philipp du Cros, MBBS, Khamraev A Karimovich, MD
…veral countries in West Africa started implementing similar regimens with similar outcomes. Evidence of effectiveness of this shortened regimen among regions with high second line drug use and resistance is still limited. The investigators propose an observational study under pr…
liu yidian
…tohydroxamic acid (AHA) capsules combined with short-course regimens (BDLLfxC or BDCZ) in patients with multidrug-resistant tuberculosis (MDR-TB). The primary objectives are to assess the safety and tolerability of AHA combined with short-course regimens, and to determine the re…
Н.В. Чумоватов, О. Г. Комиссарова, N. Chernykh, А. Э. Эргешов
…nitiated interruptions. In recent years, the use of shorter regimens for the treatment of multidrug-resistant tuberculosis has been actively discussed around the world. The first use of shorter chemotherapy regimens was conducted in three regions of the Russian Federation in 2019…
А. V. Kukurika
…ively drug-resistant tuberculosis (MDR/XDR-TB) chemotherapy regimens. Material and methods. An analysis of 19 publications devoted to the economic evaluation of the treatment of active MDR/XDR-TB was carried out. The literature search was performed in the electronic databases Pub…
М. Ф. Губкина, Yu. Yu. Khokhlovа, I. Yu. Petrаkovа, N. V. Yukhimenko
…istant tuberculosis treated by individual chemotherapy (CT) regimens. Subjects and methods : Totally, 89 children (2-12 years old) with respiratory tuberculosis, they all were exposed to multiple and extensive drug resistant tuberculosis. Patients were divided into three groups: …
Disha S. Patel, Chetankumar Acharya
Background: Tuberculosis is major cause of death in India. Analysis of heart rate variability is one of the most popular methods of autonomic nervous system evaluation. Shorter MDR-TB regimen drugs affect both central nervous system as well as peripheral nervous system. Existing …
Anthony Harries, Kudakwashe C Takarinda
BACKGROUND: Rifapentine-based regimens have potent antimycobacterial activity that may allow for a shorter course in patients with drug-susceptible pulmonary tuberculosis.METHODS: In an open-label, phase 3, randomized, controlled trial involving persons with newly diagnosed pulmo…
Gavin Koh
BACKGROUND: Rifapentine-based regimens have potent antimycobacterial activity that may allow for a shorter course in patients with drug-susceptible pulmonary tuberculosis.METHODS: In an open-label, phase 3, randomized, controlled trial involving persons with newly diagnosed pulmo…
Gustavo Velásquez, MD, MPH, Patrick Phillips, PhD, Susan Dorman, MD
…domized to SOC or one of five durations of the experimental regimens while those classified into the higher-risk group will be randomized to receive either SOC or a single fixed duration of the experimental regimen. The lower and higher-risk groups will have the following arms: …
Boubacar Diallo, Alhassane Diallo, Oumou Hawa Diallo, Alpha Oumar Barry, Aboubacar Sidiki Magassouba, et al.
… with shorter oral bedaquiline-containing versus injectable regimens in Guinea. Materials and Methods: We enrolled patients with RR-TB who were treated with an MDR-TB treatment regimen from June 2016 to June 2022 in three tuberculosis (TB) centers in Guinea. The primary outcome w…
Vivian Lofranco, Vincent M. Balanag, Lawrence O. Raymond, Noel G. Macalalad, A V Golubkov, et al.
Background: The Philippines has a burden of drug-resistant tuberculosis (DR-TB). One of the key challenges in the programmatic management of DR-TB (PMDT) is the high rate of loss to follow-up (38% in the 2010 cohort). An urgent need for a shorter, more tolerable, less expensive t…
Courtney M. Yuen, Ana Karina Millones, Jerome T. Galea, Daniela Puma, Judith Jiménez, et al.
…pants were asked to vote for preferred preventive treatment regimens and discuss the reasons behind their choices. Coding followed a deductive approach based on prior research, with data-driven codes added. Results In total, 7 (44%) participants voted for 3 months isoniazid and r…
Alina Malic, Adriana Niguleanu, Tatyana Osipov
Treatment of tuberculosis (TB) includes various therapeutic regimens with a combination of at least four drugs. Adherence to the treatment regimen is crucial for efficacy outcomes based on the achievement of appropriate drug levels. Drug-resistant () strains are mainly favored by…
Piamlarp Sangsayunh, Thanyanuch Sanchat, Charoen Chuchottaworn, Krisana Cheewakul, Sirijit Rattanawai
…eated with BPaL regimen, while the remainder received BPaLM regimens. RESULTS: Among the 28 patients, 23 (82.1 %) successfully completed the treatment with favorable outcomes. However, one patient from the BpaL regimen died due to severe destroy lung lesion, and four patients fro…
PrasantaKumar Das, SomtirthaB Ganguly
Background: Shorter multidrug-resistant (MDR) regimen has proved to be very effective in some of the developing nations such as Bangladesh and several African countries. Various shortcomings in the execution of long-term MDR regimen have prompted for adapting the shorter regimen …
Zeeshan Saleem, Imran Ullah, Muhammad Sarim Bin Farooq Awan, Jamal Tauqir, Faisal Younis, et al.
Background: Drug-resistant tuberculosis (DR-TB) is the major cause of mortality worldwide. Our objectives were to determine the distribution of DR-TB by sex, age groups, occupation, province, division, district, type of disease, type of drug resistance, treatment regimen and outc…
Malik Zohaib Ali, Taru S. Dutt, Amanda Walz, Camron Pearce, Richard Lee, et al.
…fficacy as BPaS regimen. Therefore, we tested BPaL and BPaS regimens in Balb/c (TB resistant) and C3HeB/FeJ (TB susceptible) mice infected with low-dose Mtb, and evaluated bacterial burden using colony-forming units (CFUs). Compared to untreated mice, CFUs in lungs of BPaL and BP…