Showing 126–150 of 200 documents
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Godfred Yawson Scott, Abdullahi Tunde Aborode, Ridwan Olamilekan Adesola, Klinogo Benson, Isaac Omulepu, et al.
…n. The review also discussed the integration of these novel diagnostics with digital health technologies and mobile health (mHealth) platforms. This review highlighted the potential of non-invasive diagnostic approaches and discussed the need for continued research, development, …
Ankur Gupta‐Wright
…oes undiagnosed, reflecting a failure in the approach to TB diagnostics. HIV-associated TB is often under the clinical radar, and this paper describes strategies to improve TB diagnostics to expedite treatment, reduce the amount of undiagnosed disease and ultimately reduce mortal…
Prabhdeep Kaur, Sumedha Sharma, Sudhanshu Abhishek, Ashutosh N. Aggarwal, Khushpreet Kaur, et al.
ABSTRACT Background Tuberculous pleuritis (TBP), the extra-pulmonary manifestation of tuberculosis, is the second most common after TB lymphadenitis. Histopathology using biopsy samples is the most sensitive diagnostic procedure for TBP, however the biopsy acquisition is invasive…
Klaus Reither, MD, PhD
…including the new VISITECT CD4 Advanced Disease Test (Omega Diagnostics, UK) as part of the WHO-recommended advanced HIV Disease care package in the context of community-based HIV/TB campaigns. Due to the coinciding pandemics and the overlapping symptoms of TB and COVID-19, it i…
Büşra Köse, Frieder Schaumburg
Seasonal increase of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), influenza virus A/B (Flu A/B), and respiratory syncytial virus (RSV) require rapid diagnostic test methods for the management of respiratory tract infections. In this study, we compared the diagnos…
Zaoxiu Hu, Yonghe Zhao, Yanlong Yang, Zhenghai Shen, Yunchao Huang
Abstract Objective: Recent studies indicated sputum miRNAs may provide a promising approach for non-small cell lung cancer (NSCLC) diagnosis. But some results were still inconsistent. So, we performed meta-analysis to evaluate the diagnostic role of sputum miRNAs for the detectio…
Zhifeng Liu, Yang Yang, Qingfeng Wang, Lei Wang, Wenjuan Nie, et al.
Abstract Purpose: To determine the diagnostic accuracy of a nanopore sequencing assay for testing of bronchoalveolar lavage fluid (BALF) samples or sputum samples from suspected PTB patients and compare the results to results obtained for MGIT and Xpert assays. Methods: Cases with…
Anaesthesia Technician and Private Practitioner, India, Berlin Francis
… the gap between conventional culture methods and molecular diagnostics, MGIT enhances diagnostic accuracy and supports global TB control strategies. This article explores the role of MGIT systems in tuberculosis detection, examines their contribution in integrating culture-based…
Upasana Das, Kalyani Prava Gauda, Indrani Mohanty, Atanu Kumar Bal, Sasmita Hotta
Introduction: Infection with tuberculosis is a worldwide health concern. Nearly every organ in the body can be affected by Extrapulmonary Tuberculosis (EPTB). A simple diagnosis of Pulmonary Tuberculosis (PTB) can be made using radiography and a positive sputum test. On the other…
Md Mahbub Ullah, Haris Riaz Khan, Aroosha Imran, Noman Ahmed, Kifayat Ullah, et al.
…view aimed to critically evaluate recent advancements in TB diagnostics, focusing on the integration of mass spectrometry, artificial intelligence, and genomics in comparison to conventional and molecular methods, and to assess their clinical applicability and limitations. Method…
Siavash Valafar
…revalence and co-occurrence, and their utility in molecular diagnostics. The genes commonly associated with INH resistance, katG, inhA, fabG1 , and the intergenic region oxyR’ - ahpC were considered in this review. In total, 52 articles were included describing 5,632 INH R clinic…
Qinghua Ma
Objective To investigate the diagnostic values of multi-slice spiral CT multi-directional recombination technique and simulated endoscopy for bronchial tuberculosis. Methods Eighty patients with suspected bronchial tuberculosis admitted to our hospital from September, 2018 to Sep…
World Health Organization
…ted guidelines on tuberculosis, Module 3: diagnosis – rapid diagnostics for tuberculosis detection. The publication presents evidence-to-decision tables developed to support WHO recommendations on the use of rapid diagnostic technologies for tuberculosis and drug-resistant tuberc…
Anura David, Lyndel Singh, Manuel Pedro da Silva, Keneilwe Peloakgosi-Shikwambani, Zanele Nsingwane, et al.
Abstract Background Despite advances in molecular diagnostics, only 48% of newly diagnosed tuberculosis (TB) cases were confirmed using nucleic acid amplification tests (NAATs) in 2023. The BD MAX TM MDR-TB (MAX MDR-TB) assay, a moderate complexity NAAT, detects Mycobacterium tub…
Jinyoung Bae, Sung‐Bae Park, Ji-Hoi Kim, Mi Ran Kang, Kyung Eun Lee, et al.
…ys, namely TB/NTM PCR (Biocore), MolecuTech Real MTB-ID (YD Diagnostics), and REBA Myco-ID (YD Diagnostics), were evaluated with a total of 92 respiratory specimens (22 AFB smear positives and 67 AFB smear negatives). The sensitivity and specificity of TB/NTM PCR were 100% and 75…
World Health Organization
This web annex accompanies the third edition of the WHO consolidated guidelines on tuberculosis, Module 3: Diagnosis, and presents the evidence synthesis and analyses that informed recommendations on rapid diagnostic technologies for tuberculosis (TB) and drug-resistant TB detect…
Safaa El Kassimi, Rkia Eddabra, Bouchra Belkadi, Abdelkarim Filali‐Maltouf, Hassan Ait Benhassou
…F Ultra, and Xpert MTB/XDR (Cepheid) have revolutionized TB diagnostics by offering automated, rapid detection with high sensitivity and specificity, especially in resource-limited settings. High-throughput platforms like COBAS MTB and MTB-RIF/INH (Roche) and line probe assays su…
Ranjit Suva, Gaurang Khadiya, Kinjal D. Rami, Urvashi S Modh, Firoz Ghanchi, et al.
…ate the clinical implications of using CBNAAT in routine TB diagnostics.
Jingwen Ai, Xian Zhou, Teng Xu, Minling Yang, Yuanyuan Chen, et al.
Rapid and simple-to-use diagnostic methods for tuberculosis are urgently needed. Recent development has unveiled the diagnostic power of the CRISPR system in the detection of viral infections. However, its potential use in detecting the <i>Mycobacterium tuberculosis</i> complex (…
Maria Naseer, Salahuddin Balooch, Umar Amin, Muhammad Amin, Muhammad Usman Ghani Khan, et al.
Objective: To assess the diagnostic accuracy of high resolution computed tomography (HRCT) of chest in diagnosing sputum smear positive and negative pulmonary tuberculosis (PTB). Study Design: Cross-sectional study. Setting: Tertiary Care Hospital, Kharian Cantt. Period: Oct 2021…
Jingwen Ai, Xian Zhou, Teng Xu, Minling Yang, Yuanyuan Chen, et al.
Rapid and simple-to-use diagnostic methods for tuberculosis are urgently needed. Recent development has unveiled the diagnostic power of the CRISPR system in the detection of viral infections. However, its potential use in detecting the <i>Mycobacterium tuberculosis</i> complex (…
Hoa Le, Quoc-Khanh Tran-Le, Khoa Nguyen-Dang, Ngoc Duong-Minh, Vu Le-Thuong
With an estimated global incidence of 360 cases per 100,000 annually, pleural effusion is a substantial health burden. In TB-endemic, resource-limited settings, timely diagnosis remains challenging. When pleural fluid analysis and clinico-radiologic evaluation are nondiagnostic, …
Yoyos Dias Ismiarto, Ahmad Ramdan, Doddy Putra Pratama Sudjana, AMA Rahim, Abdul Kadir Hadar
Introduction Spinal tuberculosis is an extra-pulmonary tuberculosis infection caused by Mycobacterium tuberculosis (MTB) which affects the vertebrae. Culture test is the «gold standard» diagnostic method, but it takes a long time. PCR is a method of a shorter time than the cultur…
Wen P, Wang SX, Ma XM, Chen HY, Ma ZX, et al.
Peng Wen,1,&ast; Shang Xue Wang,1,&ast; Xiao Man Ma,1 Hong Yan Chen,1 Zeng Xia Ma,1 Yun Zeng Zhang,2 Min Wei1 1Department of Respiratory Medicine, Public Health Clinical Center Affiliated to Shandong University, Jinan, People’s Republic of China; 2Department of Thoracic S…
Laura Olbrich
Tuberculosis (TB) remains a major cause for morbidity and mortality in children, and the very young and immunocompromised are especially at high risk. A major hurdle is a timely diagnosis, as microbiological confirmation – regarded as the reference standard – remains uncommon and…