Showing 101–125 of 200 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Sunday Olakunle Olarewaju, Sunday Charles Adeyemo, Ayomide Timilehin Kayode, Janet Oluwaseyi Ayinmodu, Olushina Ololade Oladeji, et al.
ABSTRACT Tuberculosis (TB), an infectious disease caused by Mycobacterium tuberculosis is still one of the leading public health problems, despite advances in the effort to reduce its incidence, morbidity, and mortality. Studies have shown that the prevalence of depression correl…
Kuppli Sai Sushma, Devi Madhavi Bhimarasetty, Siva Kumar Lotheti
…sent study was taken up to assess the treatment outcomes of Tuberculosis among TB-HIV co-infected patients and certain factors related to the poorer outcome of the treatment. An Observational Longitudinal study conducted at an ART centre, attached to King George Hospital in Visak…
Malika Gabdullina, Saya Gazezova, Gulzhan Ayapova, Manar Smagul, Roberta Horth, et al.
… study among all people newly diagnosed with drug-sensitive tuberculosis over 18 years old who initiated treatment from 2018-2021 in Almaty. We abstracted data from the national tuberculosis electronic database. Unfavorable treatment outcomes were sorted as follows: ineffective t…
Diah Ayu Kamila, Hartati Eko Wardani, Tika Dwi Tama, Anindya Hapsari, Rara Warih Gayatri
… that contribute the most mortality of TB in the world. The tuberculosis treatment success rate in Indonesia is 86% meanwhile is still far from the target coverage of the TB treatment success rate (90%). This study conducted to determine the determinant factors of successful TB t…
Malaisamy Muniyandi, Karikalan Nagarajan
With the currently recommended 6-month antituberculosis therapy (ATT), 85% of people with drugsensitive tuberculosis could be cured.1 However, this regimen still requires four medications and a minimum of 6 months of therapy. Long duration of treatment and drug-related toxicity l…
Tao Huang, Qing Chen, Guihui Wu, Shenjie Tang
…ed medical basis across three key aspects: drug-susceptible tuberculosis (DS-TB), drug-resistant tuberculosis (DR-TB), and treatment and care. This article offers an interpretation of the guideline from the perspectives of its recommendations, evidence-based medical basis, core u…
Jianghua Yang, Jian Sun, Wenjie Wang, Jing Ding, Yusheng Cheng, et al.
Abstract Background Duration of antituberculosis therapy (ATT) for managing female genital tuberculosis (FGTB) is controversial with the intermittent regimen no more advocated. We therefore conducted a prospective, real-world research to compare 6 months and 9 months of ATT. Meth…
Susan Shin-Jung Lee, MD, PhD
Tuberculosis remains an important global health problem, and the world is currently not on track to end the TB epidemic by 2030. With the concerted efforts of the government and medical community, the incidence of TB in Taiwan has gradually decreased, however, Taiwan remains an e…
Beijing Chest Hospital
… shorter-course BLMZ regimen can treat Rifampicin-Resistant Tuberculosis (RR-TB) in Chinese participants aged 12 years and older. The main questions it aims to answer are: What is the proportion of participants with a favorable outcome at 18 months after starting the BLMZ regime…
Nathan Hicks
Tuberculosis (TB) disease, caused by Mycobacterium tuberculosis (Mtb) infection, affects millions of people across the world annually. The best tool for controlling TB in individual patients and preventing transmission in populations is combination antibiotic therapy. Six months …
Christian Noel Dide-Agossou
…tment regimens for both drug-susceptible and drug-resistant tuberculosis (TB) are urgently needed. The key roadblock in TB regimen development is lack of valid surrogate pharmacodynamic markers for TB relapse. A recently-proposed assay called the ribosomal RNA (rRNA) synthesis (R…
Dominic Wang, Kara M. Ruicci
…Sputum samples revealed the presence of drug-susceptible M. tuberculosis and treatment guidelines were reviewed. The patient demonstrated response to first-line therapy, rifampin and isoniazid, and was subsequently discharged with follow-up chest x-ray. Tuberculosis is further di…
Chunyan Fan, Xiaoli Ye, Chengpeng Wang, Yuqing Wu, Bin Tong, et al.
…nd safety of vitamin D (VD) supplementation among pulmonary tuberculosis (PTB) adults receiving standard anti-tuberculosis (TB) therapy. This systematic review and meta-analysis were conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analys…
Christian Noel Dide-Agossou
…tment regimens for both drug-susceptible and drug-resistant tuberculosis (TB) are urgently needed. The key roadblock in TB regimen development is lack of valid surrogate pharmacodynamic markers for TB relapse. A recently-proposed assay called the ribosomal RNA (rRNA) synthesis (R…
Simran Sharma, Rohit Ajitsingh Macharekar, Tirumalai R. Raghunand
…antibiotics to penetrate and effectively kill Mycobacterium tuberculosis (M. tb), the causative organism of human tuberculosis (TB).Additionally, intrinsic resistance mechanisms that either degrade or modify antibiotics further reduce the effectiveness of anti-TB drugs. To overco…
Muhammad Ramadhan, Alidina Nur Afifah, Muhammad Fachri, Farsida Farsida
Background: Tuberculosis (TB) is a global health issue, with over 10 million cases worldwide, and Indonesia ranks as the second-highest country with TB cases. The comorbidity of diabetes mellitus (DM) increases the risk of TB, especially in elderly patients. TB patients with DM a…
A. Sontakke, P. Murarka, Rachana A Sontakke
…an 12 years who had completed their treatment for pulmonary tuberculosis were assessed over a follow-up period of six months. Patients were evaluated at three intervals: after treatment completion (within 2 weeks), after three months and after six months, using chest X-rays, six …
Mainak Mukherjee, Susmita Kundu, Rivu Basu
<b>Introduction:</b> Pulmonary Tuberculosis in majority of cases is reactivation TB, which is mostly due to drop in immunity. Substance use compromises immunity and promote secondary TB in substance dependents. <b>Objective:</b> To study the effect of Substance dependence on Pulm…
M.G. Mustapha, Garba Mohammed Ashir, AI Rabasa, Asmaa Farouk, Hassan Abdullahi Elechi, et al.
Tuberculosis (TB) is an important infectious disease of public health concern. The effects of TB on children in terms of morbidity and mortality is more than that of adults. These may not be unconnected with the differences in characteristics and peculiarities of the disease in c…
John Metcalfe, MD, PhD, MPH
…th standard of care (SOC) regimen for drug-susceptible (DS) tuberculosis (TB). This study compared a 3-month rifapentine (RPT)/clofazimine (CFZ)-containing regimen with a CFZ loading dose with the 6-month standard of care (SOC) for drug-susceptible (DS) tuberculosis (TB). Rando…
J Daniel, M R Marll, N Mofokeng, T Ngwanto, N Glover, et al.
Abstract Rationale Post-tuberculosis lung disease (PTLD) has been increasingly recognized as a significant global health challenge, with nearly half of tuberculosis (TB) survivors having impaired lung function despite microbiologic cure. Previous studies have identified an associ…
Suraj B. Sable, Wen Li, Allison Kline, Sakthivel Govindaraj, Vijayakumar Velu, et al.
…ategy in combating both drug-susceptible and drug-resistant tuberculosis (TB). Current evaluations, however, show limited success in animal models and clinical settings, emphasizing the need for more effective HDT candidates. With few druggable targets validated within granulomas…
Alexandra V. Solovyeva, Grigory Volchenkov, O. Ponomarenko, Tatiana A. Kuznezova, Tatiana R. Somova, et al.
ABSTRACT Introduction Rates of drug-resistant tuberculosis (TB) are increasing worldwide. TB preventive treatment (TPT) for contacts of active TB patients is essential to halt infection progression and transmission. While newer TPT regimens for drug-sensitive strains are expandin…
Othman Zeyad O Alhekail, Navneet Singh, Elisabeth Hansen, James C. Johnston, Victoria J. Cook, et al.
Abstract Background Tuberculosis (TB) remains a significant global health threat. Upon diagnosis, patients with pulmonary TB are required to undergo specific isolation precautions to prevent further disease transmission. Current practice typically mandates isolation for at least …
Chabala, Chishala
Children with HIV are highly susceptible to tuberculosis (TB) and often require concurrent antiretroviral treatment (ART) and antituberculosis therapy. However, rifamycins, the key drugs for TB treatment, significantly interact with many ART classes, necessitating adjustments to …