Showing 101–125 of 196 documents
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Trevor Hansel, FRCPath, PhD, Peter JM Openshaw, FRCP, PhD, FRSB, FMedSci, Robin Shattock, PhD
…will be managed as per GCP and local Information Governance guidelines. NUMBER OF SUBJECTS AND DOSING PART 1: Nasal ascending dose challenge with microbial constituents using MPLA, polyIC, polyICLC and resiquimod. This is divided into part A and part B. PART 1A (n=32): Increme…
Mariano Victor, Andrade Laíla, Oliveira Fernanda, Santos Monique, Pereira Martins Fernanda, et al.
…e, potent immunosuppressive therapy has become the standard treatment for inflammatory bowel disease (IBD) (1). However, the increasingly use of immunomodulators associated to biological therapy—especially the inhibitors of tumor necrosis factor alpha (TNF-α)—have considerably in…
Gèrard de Vries, Jossy van den Boogaard, Ibrahim Abubakar
…ation was unchanged in the 2021 update [[3]WHO consolidated guidelines on tuberculosisModule 2: screening - systematic screening for tuberculosis disease. World Health Organization, Geneva2021Google Scholar]. The specific details of the combination of tools to use in such screeni…
Sashi N Nair, Indira Brar, Gireeshkumar K.P.
…cribed in HIV infected patients. Developed countries, where guidelines on the treatment of PJP have been created have dramatically lower rates of latent and active TB than developing countries. PJP may obscure the diagnosis or delay the treatment of TB. Furthermore, treatment of …
Joyce W.Y. Mak, Joseph J.�Y. Sung
… of concerns for the use of these drugs in the East. First, latent infection is a major threat when using potent immunosuppressive agents. The high prevalence of subclinical or past infection of tuberculosis, viral hepatitis, and other latent infections poses potential danger of …
Ghassan Ilaiwy, Jessica Keim‐Malpass, Romella Tuppal, Alexander F. Ritua, Flordeliza R. Bassiag, et al.
…d a cost effectiveness analysis evaluating the expansion of latent TB testing and treatment among pediatric (5-14 years) household contacts of index TB patients in the Philippines. Methods : Using a Markov state transition model, eligible household contacts (HHCs) age 5-14 years …
S Pappas, Y Zhu, S Hegeman, D S Mohamed, N Kalra, et al.
…sts between Omalizumab and pulmonary disease, nor are there guidelines recommending TB screening before therapy [6]. A single report described a 32-year-old Filipino woman diagnosed with pulmonary and extrapulmonary TB after starting Omalizumab for CSU [7]. Mast cells play a para…
Arafa Djalal, Justin Côté-Daigneault
Inflammatory bowel disease (IBD) patients undergoing treatment with biological therapy are at increased risk of developing opportunistic infections such as tuberculosis (TB). Screening for latent tuberculosis is mandatory before initiating biological therapy such as Anti-TNF alph…
R. De Luca E Tuma, Amina Jama, Susan Dart, Verónica White, Christabelle Chen, et al.
…of MDR-TB in East London remain high. There are no existing guidelines for treating close contacts of newly diagnosed MDR-TB cases in low TB incidence countries. This study aims to analyze the rates of MDR-TB among close contacts of TB index cases with pulmonary MDR-TB in East Lo…
World Health Organization. Regional Office for Europe
…lding for consultants on the new WHO recommendation for the treatment of drug-resistant tuberculosis” on 15–18 June 2020. The objectives of the training session included capacity-building of the new and existing regional Green Light Committee for the WHO European Region (rGLC/Eur…
Maria Mironova, Irina Y. Gutierrez Puentes, Rajashree Anandakrishnan, Anil R. Balani
…or necrosis factor alpha (anti-TNF) medication used for the treatment of moderate-to-severe Crohn’s disease and ulcerative colitis. Tuberculosis (TB) has remained a serious side effect of anti-TNF therapy despite routine TB screening. We report a case of a young male who develope…
Farah Daas, Rafael Ruiz‐Gaviria, Bhakti Thummar, Naveera Khan, Sheena Ramdeen
…y (IGRA) is frequently ordered in hospitalized patients for latent tuberculosis (TB) screening. Health care workers must be cautioned that acute and critical illness exert a significant effect on IGRA performance, so delaying screening to the outpatient setting is preferred if fe…
Rebecca Berhanu, Karen R. Jacobson
…st benefit is observed in those with a positive result on a latent TB infection test, which is not ...References1. Samandari T, Agizew TB, Nyirenda S, et al. 6-month versus 36-month isoniazid preventive treatment for tuberculosis in adults with HIV infection in Botswana: a random…
Kendra Brett, Melissa Severn
It is not known if screening for latent tuberculosis infection (LTBI) is useful for reducing the risk of tuberculosis reactivation among people at risk (no evidence was found). In people with LTBI, providing treatment for the latent infection may be helpful for preventing the dev…
Adrienne E. Shapiro, Ayushi Gupta, Kristine F Lan, H. Nina Kim
…in the US is reactivation TB in non-US-born (nUSb) persons. Guidelines recommend screening persons born in high TB burden countries for latent TB infection (LTBI) and treating if positive. We evaluated the LTBI cascade in primary care among nUSb persons in a large academic medica…
World Health Organization
…perience since the publication of the 2021 consolidated HIV guidelines and aims to support progress towards ending AIDS as a public health threat by 2030. The document addresses the use of preferred and alternative antiretroviral regimens across different populations, including a…
Faiza Aiman Khan
…nd the world emphasize on its early detection and immediate treatment to reduce the transmission of infectious cases Primary Health care providers play an essential role in detecting and diagnosing suspected TB cases, and referring them for treatment, thus helping to prevent spre…
Carlo Foppiano Palacios, Amit C. Achhra, Lydia Barakat, Michael Virata, Richie Hao, et al.
…at increased risk of reactivation of tuberculosis (TB) from latent tuberculosis infection (LTBI). Current guidelines recommend all PWH be initially screened for LTBI with either interferon-gamma release assays (IGRA) or tuberculin skin testing (TST). Also, repeat screening is rec…
Suman Majumdar, Rina Triasih, Stephen M. Graham
…is by 2030 cannot be achieved without a strategy to address latent infection that is subclinical or quiescent.2Rangaka MX Cavalcante SC Marais BJ et al.Controlling the seedbeds of tuberculosis: diagnosis and treatment of tuberculosis infection.Lancet. 2015; 386: 2344-2353Summary …
Anita Uka, Frédéric Méchaï, Daniela Maria Cirillo, Lorenzo Guglielmetti, Yousra Kherabi, et al.
…imen selection, use of microbiological and molecular tests, treatment regimens for active and latent TB, monitoring practices, and adherence to international (WHO 2022, ERS/ECDC 2017 and IJTLD 2023) guidelines. Descriptive analyses were performed to summarize practices and identi…
Chris J Griffiths, DPhil, MB BS
…ance level. Secondary outcomes are rates of prophylaxis for latent TB infection (LTBI), BCG immunisation, smear negative (early) TB and costs. Analyses will be by intention to treat. To date, studies of screening for tuberculosis have used relatively weak designs. A randomised t…
Eka Kokhreidze, Zaza Avaliani, Nino Gabashvili, Maia Zamutashvili
The uptake of latent tuberculosis infection treatment (LTBI) is an important measure to prevent active tuberculosis (TB), but has not been well studied in low and middle-income countries (LMICs). The lifetime risk of developing active TB for people with LTBI is 10-15%. Within the…
Alberto L. García‐Basteiro, Helen E. Jenkins, Molebogeng X. Rangaka
…uggest that around 25% of the world's population could have latent tuberculosis infection,2Houben RMGJ Dodd PJ The global burden of latent tuberculosis infection: a re-estimation using mathematical modelling.PLoS Med. 2016; 13e1002152Crossref PubMed Scopus (933) Google Scholar 5–…
Dr Rajendra Tatu Nanavare
… cancer, especially in individuals with a history of cancer treatment and tobacco use. Through a detailed analysis of clinical cases, we explore the complexities associated with TB reactivation post-cancer therapy and the hurdles in timely diagnosing lung cancer in tobacco users.…
Ammara Masood, Yawen Xiang, Safiya Rose-Hartwell, Sujith Subesinghe
…t Background/Aims The 2018 British Society for Rheumatology guidelines mandate pre-treatment screening for infections (including tuberculosis [TB], viral hepatitis and HIV) in patients prior to treatment initiation with advanced therapies. It is increasingly common for patients t…