Showing 51–75 of 200 documents
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Heather J. Zar, Mark P. Nicol
Pediatric tuberculosis is a global concern, with children estimated to account for 10% to 15% of the overall case load, representing almost 1 million cases annually. However, modeling estimates indicate that only 30% of childhood tuberculosis cases are diagnosed and notified.1 Di…
Sushil Kumar Kabra
Diagnosis of Tuberculosis in children is challenging. Major challenge is because of difficulty in obtaining representative airway samples and paucibacillary nature of illness. Significant improvement occurred over past few years. However, the sensitivity and specificity of labora…
Yalçın Kara
Tuberculosis is an infectious disease caused by the Mycobacterium tuberculosis bacteria with high mortality and morbidity. Especially, delay in diagnosis and treatment of childhood tuberculosis causes an increase in adult tuberculosis. According to the World Health Organization, …
Laura Moretó Planas, MD
Tuberculosis (TB) diagnosis in children is challenging in low and middle-income countries where access to TB culture and X-ray is limited. More than half cases of childhood TB remain undiagnosed every year. A delay in TB diagnosis can lead to an increase in preventable morbidity …
Min Yu, Qi-Jun Jiang, Yuqing He, Fei Zhao, Tang-Ming Jin, et al.
Clinical manifestations of pediatric pulmonary tuberculosis (PTB) are atypical, making diagnosis challenging. This study aims to analyze the clinical characteristics of PTB to provide constructive suggestions for the diagnosis of PTB. A retrospective analysis was conducted on ped…
M.J. Cavaco, Sofia Giusti Alves, L. Mateus, André Nunes, Ricardo Cordeiro, et al.
<b>Introduction:</b> Early diagnosis of tuberculosis (TB) is essential to achieve cure and to reduce disease transmission. Total diagnostic delay (TDD) can be divided in patient delay (PD - from symptoms onset to seeking a health care facility) and health system delay (HSD - from…
Alexandra R Linn, Andrew P. Steenhoff
…ground The WHO currently estimates that at least a third of pediatric and adolescent tuberculosis cases go untreated or incompletely treated each year. Many cases are detected but lost to follow-up due to underreporting to national or private surveillance systems. Methods We cond…
Srabani Banerjee, Melissa Severn
Tuberculosis (TB) is one of the top 10 causes of death, worldwide. Worldwide 10 million people developed TB in 2017, (i.e.,133 cases per 100,000).– However, only 6.4 million cases were reported to WHO, indicating that 36% of cases were undiagnosed or not reported. According to a …
Patricia Comella-del-Barrio, José Luis Izquierdo-García, Ramón Campos‐Olivas, Clara M. Santiveri, Jesús Ruı́z-Cabello, et al.
Children’s paucibacillary tuberculosis (TB) and their difficulty to expectorate leads to low diagnostic sensitivity. Most TB in children are diagnosed by clinical scoring systems limited by the TB clinical presentation. Pediatric TB diagnosis research should be focused on new bio…
Ahang Hasan Mawlood
Background and objective: M. tuberculosis is one of the main causes of morbidity and mortality in many countries and is considered a priority global health problem. Although it is a curable disease, every year about nine million people develop active disease, and two million die …
Spinal tuberculosis in pediatric patients is frequently associated with multiple vertebral lesions and could be complicated by kyphosis. The diagnosis should be confirmed by culturing or molecular–genetic study of the pathological tissues that are harvested from the zone of bone …
Jyoti Sharma, Sanjeev Chaudhary, Sandesh Guleria, Vipan Garg, Anju Bala
…AAT) positivity in presumptive pulmonary and extrapulmonary tuberculosis (EPTB) in pediatric patients.Materials and methods: It was a descriptive observational study done in pediatric presumptive pulmonary tuberculosis (PTB) and EPTB patients in a tertiary care institute of north…
Zainab Farooq, Hamza Sajid, Noor Un Nisa Irshad, Sakan Binte Imran
To the Editor, Pediatric TB is a significant global public health issue, with accurate diagnosis being a primary barrier to finding and treating afflicted children. According to WHO Global Tuberculosis Report 2024, an estimated 10.8 million people were diagnosed with TB worldwide…
Shu‐Han Yu
As a new immunoassay, T-SPOT.TB has been widely used in the diagnosis of tuberculosis in children.A large number of clinical trials show that it has better sensitivity and specificity simultaneously, compared with other diagnostic methods for tuberculosis in children.This article…
M.D. Zvereva, Sunita Kanash, S.I. Petrova, В. А. Евсеев, Elena Malyarova, et al.
Diagnosis of tuberculosis in children is challenging because of variable clinical symptoms and no specific signs. We report a case of tuberculous osteomyelitis of the ribs, which demonstrates difficulties associated with the diagnosis of generalized tuberculosis in an 8-year-old …
Suba Guruprasad, Mukesh Sanklecha, Rama Yelikar
To study the usefulness of Xpert TB/Rif in diagnosis of childhood tuberculosis in India. Prospective study was including children from 1 month to 18 years of age with clinical suspicion of tuberculosis. All cases were classified as pulmonary and extra pulmonary tuberculosis based…
A Mosses, D Philbert, F Ngadaya, D Solomon, F Msafiri, et al.
Abstract Rationale Tuberculosis (TB) is a significant public health problem in sub-Saharan Africa, affecting individuals of all ages, including children. Tanzania, one of the countries with a high TB burden, faces persistent challenges in the timely diagnosis and treatment of ped…
Yiheyis Genetu, Bethelhem Belay, Workeabeba Abebe
Background: Approximately 81% of all childhood tuberculosis cases occur among 22 high-burden countries and Ethiopia ranks eighth among these high burden countries. The GeneXpert Mycobacterium tuberculosis DNA and resistance to rifampicin (MTB/RIF) test can detect pediatric tuberc…
AW Mesman, María José Morán Soto, Julia Coit, Róger Calderón, Juan Aliaga, et al.
Abstract Background Rapid and accurate diagnosis of childhood tuberculosis (TB) is challenging because children are often unable to produce the sputum sample required for conventional tests. Stool is an alternative sample type that is easy to collect from children, and studies in…
The COVID-19 pandemic has affected the diagnosis and treatment of pediatric tuberculosis (TB), which can pose a public health burden if not properly treated. This study aims to find out the risk factors for pediatric TB. The design of this study was cross-sectional, using TB surv…
NanoPin Technologies, Inc.
…stigate the accuracy of the NanoDetect-TB kit in diagnosing tuberculosis (TB) using frozen serum and plasma samples collected from individuals suspected to have TB disease. The main question\[s\] it aims to answer are: * How does this investigational device compare to the gold …
Muhammad Abbud Widitaputra, Retno Asih Setyoningrum, Agus Harianto
Tuberculosis, caused by Mycobacterium tuberculosis, is transmitted through the release of bacteria into the air via respiratory activities, such as breathing and coughing. Untreated latent tuberculosis can act as a reservoir for future infections. Remote regions like Masalembu en…
Andreia Leite, Pollyanna Mafra Soares, Jêniffer Costa Dos Santos, Carla Nunes
Abstract Background Delays in diagnosing tuberculosis lead to longer infectious periods, posing a challenge in tuberculosis control. This is particularly relevant in high incidence areas (critical). Thus, the objectives of this work were to characterize tuberculosis diagnosis del…
Joelma Clotilde Costa Da Silva, Emília Marcelina Dos Santos, Dionisio Mendes, Raquel Duarte
<b>Introduction:</b> Delay in tuberculosis diagnosis implies a delay in its treatment and perpetuation of the transmission chain. This delay may be due to the patient, but it may also be due to the health system. <b>Objectives:</b> This study aimed to identify factors associated …
Zahra Hasan, Sadia Shakoor, Rumina Hasan
…ountries (LMICs) with a high burden of infectious diseases. Tuberculosis (TB), a major source of morbidity and mortality worldwide, was further exacerbated by the COVID-19 pandemic, resulting in up to 1.5 million deaths in 2020 [[1]WHOGlobal tuberculosis report 2021. World Health…