Showing 51–75 of 196 documents
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Sophie Forsyth, Tolulope Subuloluwa, Myat Lwin, Jessica Henderson Daniel
<h3>Introduction</h3> 2018 BHIVA Tuberculosis (TB) guidelines recommend testing people living with HIV (PLWH) from countries with high and medium TB incidence for LTBI and from low-incidence countries if they have additional TB risk factors. We had not yet introduced this in our …
James O’Connell, Eoghan de Barra, Cora McNally, Samuel McConkey
Aim Knowledge of latent tuberculosis infection (LTBI) screening and treatment practices are lacking in Ireland, where LTBI is not programmatically surveyed or managed. The aim of this research was to describe current clinical practice when screening and treating patients for LTBI…
Ling Chen, Lifan Zhang, Leidan Zhang, Liyuan Zheng, Jia Tang, et al.
…hain of anti-TB drugs, and insufficient understanding of TB treatment guidelines. China has always been regarded as a region with high TB burden. Therefore, conditional TB prophylaxis has been recommended in national guidelines for HIV-infected patients since 2006, with emphasis …
Simon Tiberi, Giovanni Battista Migliori, Jeremiah Chakaya, Tereza Kaesava, Seif Al-Abri, et al.
…nd-tb.Google Scholar) to: scale up access to prevention and treatment; build a multisectorial accountability; ensure sufficient and sustainable financing including research; promote an end to stigma and discrimination, and promote an equitable, rights-based and people-centered TB…
Qiaoling Ruan, Jingyu Zhou, Shufeng Weng, Lingyun Shao, Wenhong Zhang
…leading cause of death among infectious diseases worldwide. Latent tuberculosis infections (LTBI) contribute to the global burden of TB disease. TB preventive treatment (TPT) is a key intervention to achieve the End TB Strategy targets. The World Health Organization recommends LT…
Bárbara Manuella Cardoso Sodré Alves, Melina Mafra Toledo, Ivan Ricardo Zimmermann, Wildo Navegantes de Araújo, Noêmia Urruth Leão Tavares
Background The treatment strategy for latent tuberculosis (TB) infection (LTBI) aims to promote a reduction in the number of cases that develop into TB and, consequently, a reduction in the transmission of pathogenic bacteria. Objectives The objective was to know the safety, effe…
Saurabh Dawra, Nipun Verma
…ients are immunosuppressed and are predisposed to flares of latent or incident infections.[1] Post-LT patients in India, a high burden country for tuberculosis(TB)[2] and liver disease-related immune dysfunction, are predisposed to acquire tubercular infections.[3] While treatmen…
Daniel Yi Liang Tan, Young-Hoon Kim, Zeeshaan Hasan, Anthony Bewley, Sarah Mehrtens, et al.
… autoimmune dermatological conditions as an option if other treatments are unsuccessful or contraindicated. However, one major side-effect of biologics is immunosuppression, which may lead to the reactivation of latent tuberculosis (TB) in patients. The British Association of Der…
Ajit Lalvani, Clementine Fraser, Manish Pareek
…at M.tb infection, even at very low bacterial burdens as in Latent tuberculosis infection (LTBI), evokes a strong Cell-mediated immunity response to M.tb antigens. LTBI was previously thought to represent a uniform state. However, as research progresses it has become clear that L…
University of Colorado, Denver
…eloping fetus. Additionally, women considering rifampin for treatment of LTBI face additional risks with an unintended pregnancy, making the reliability of contraception even more important for these women. The results of this study can directly inform counseling on a national an…
Deborah Kirkham
<h3>Introduction</h3> National tuberculosis (TB) HIV guidelines published in 2018<sup>1</sup> recommend latent TB testing with interferon gamma-release assay (IGRA) in at-risk populations. <h3>Methods</h3> The HIV department liaised with the TB department to develop a referral pr…
Matthew Burman, Dominik Zenner, Andrew Copas, Lara Goscé, Hassan Haghparast‐Bidgoli, et al.
<h3>Introduction</h3> The control of latent tuberculosis infection (LTBI) is a key priority in national and global strategies to eliminate tuberculosis (TB). We tested whether a novel community model of care delivered by general practitioners (family physicians) and community pha…
Thomas B Nutman, M.D.
…the lungs and can spread elsewhere in the body. People with latent TB have the bacteria that lie dormant but can become active and cause disease. These people are offered treatment to prevent development of active TB. Worldwide, a lot of people with LTBI also have a parasitic wor…
Lynn Sosa, Lloyd N. Friedman
This chapter discusses the guidance on options for treatment recommended by established national and international organizations. Generally, practitioners should follow the guidelines specified by the organization that represents the geographical location of the treatment facilit…
Anjana Dogra, Sheetal Agarwal
… Health Organisation (WHO) recommendations and updated NTEP guidelines on the diagnosis, treatment and prevention of TB in children. Literature was identified from WHO reports, national programme guidelines and recent peer-reviewed studies focusing on molecular diagnostics, drug-…
Kaisheng Su, Ximeng Li, Zhenyu Jiang, Yifang Mei
…tor inhibitors (TNFi) has brought disruptive changes to the treatment of rheumatic diseases (RDs). The application of biological therapy represents a milestone in the tremendous progress of precision medicine. Due to the rapid advances in RD's etiology, it has been wildly reporte…
A-Dong Shen, Master
The management of latent Mycobacterium tuberculosis infection is a new priority action for the WHO End Tuberculosis (TB) Strategy. However, national guidelines on latent tuberculosis infection testing and treatment have not yet been developed in children of China. Here, we presen…
Marshall Ahearn, Carla Piedrahita, Deborah Bissette, L. Beth Gadkowski, Jussi Saukkonen, et al.
AbstractBackgroundTreatment of latent tuberculosis infection (LTBI) is a key component in U.S. tuberculosis control, assisted by recent improvements in LTBI diagnostics and therapeutic regimens. Effectiveness of LTBI therapy, however, is limited by patients’ willingness to both i…
Rebecca F. Baggaley, Christopher Martin, Helen Eborall, Marjan Gohar, Kashif Aziz, et al.
…ive patients attending clinic, 7% had active TB and 92% had latent TB infection. 55% of active TB, 99% of latent TB, 61% of HBV, 35% of HIV and 83% of HCV infections were new diagnoses. There were high rates of linkage to care for those newly diagnosed. 98% of new latent TB patie…
Ying He, Yan Deng, Hai Yi
…t reduced compared with those before the first chemotherapy treatment, and there was partial necrosis in zone II. A puncture biopsy of the left neck mass (Figure 1) demonstrated necrotizing granulomatous inflammation in lymphoid tissue, immunohistochemical staining was negative f…
Vladimir Milanov, Nikolay Yanev, Natalia Gabrovska, Denitsa Dimitrova, Elizabeta Bachiyska, et al.
Isoniazid (H; INH) is an important first-line drug for the treatment of active tuberculosis (TB) and latent TB infection because of its potent early bactericidal activity against Мycobacterium tuberculosis. Currently, TB resistant to INH, alone or in combination with other drugs,…
Simon Christie, Jessica Potter
…er a quarter of the world’s population is estimated to have latent tuberculosis infection (LTBI), with 5–10% expected to develop active TB. Hepatotoxicity is a well described side-effect of anti-tuberculosis medication, often leading to disruptions in treatment. Currently, NICE g…
Rebecca F. Baggaley, Carolin Vegvari, Christian Akem Dimala, Marc Lipman, Robert F. Miller, et al.
…ims of the related manuscript: “Health economic analyses of latent tuberculosis infection screening and preventive treatment among people living with HIV in lower tuberculosis incidence settings: a systematic review”.In a systematic review, the related study assessed cost-effecti…
Hannah Tan, Arlene Dy-Co
…is remains to be a major cause of morbidity in children and treatment of latent tuberculosis is important to prevent children from developing active tuberculosis. This study aimed to compare the effectiveness, safety, compliance, and cost of the currently available Latent Tubercu…
Grant Theron, PhD, Balthazar Nyombi, PhD, Kidist Bobosha, PhD, Carol Holm-Hansen, PhD
…illion persons live with active TB. While the prevalence of latent TB is very high, only disease, and not latent infection, is treated in most high burdened countries. A rapid triage test for detection of active TB, which can identify symptomatic individuals who require confirma…