Showing 26–50 of 200 documents
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Alfonso J. Rodríguez‐Morales, Aula Abbara, Francine Ntoumi, Nathan Kapata, Peter Mwaba, et al.
World Tuberculosis (TB) Day, March 24th, 2023, will commemorate the day in 1882 when Professor Robert Koch announced his discovery of Mycobacterium tuberculosis (Mtb) when TB ravaged Europe. Over a century later, in 1993, the World Health Organization (WHO) declared TB a global h…
Dara, Masoud, Gozalov, Ogtay, World Health Organization. Regional Office for Europe
…e on the “Programmatic aspects of the implementation of new tuberculosis drugs and regimens” co-organized with the Laboratories, Diagnostics and Drug-resistance team of the Global TB Programme (GTB). The objective of the rGLC/Europe meeting and following workshop were to discuss …
Moo Sang Chong, Kyutaeg Lee
… Among the cases that showed resistance to one or more anti-tuberculosis drugs, 55 patients (33.1%) were resistant to isoniazid (INH) at the time of initial referral, and the rates for the development of resistant anti-tuberculosis drugs were ethambutol (EMB) (26.6%), rifampicin …
Iryna Makoida, Мykola Ostrovskyy, Iryna Kostitska, Оlga Molodovets, Olga Melnyk-Sheremeta, et al.
<bold>Background:</bold> The coexistence of the:tuberculosis(TB) and diabetes mellitus(DM) epidemic, however, complicates the clinical course of both conditions, which negatively impact the quality of life for patient. <bold>Purpose of the study:</bold> to analyze the impact of c…
Kartik Chadhar
Tuberculosis (TB), despite extensive global efforts for elimination, continues to pose significant public health challenges, particularly in high-burden countries like India. This review explored the isolation of active (open) TB cases as a critical strategy to curb transmission …
David Kajoba Mumena, Geoffrey Kwenda, Caroline Ngugi, Andrew Nyerere
Drug-Resistant Tuberculosis (DR-TB) causes high mortality and morbidity rates globally. DR-TB and COVID-19 pandemic are posing a major risk to global public health and economic security, and are jeopardizing efforts in the control, prevention and elimination of TB globally. Mycob…
Abdelgawad, Noha
Tuberculosis (TB) is the primary cause of death from a single infectious agent worldwide. During the coronavirus disease (COVID-19) pandemic, TB briefly fell to second place, but it has now regained its position as the top infectious killer. It is caused by Mycobacterium tubercul…
Medina
With 5,000 new active cases each year, tuberculosis in Chile remains as the most important communicable disease in the country. Since the type of control programs are linked to the epidemiologic situation as far as infection, morbidity and mortality are concerned, an effective su…
Diana Vakhrusheva, Kseniya Belousova, Tatyana Umpeleva, Natalya Eremeeva
…sults of drug susceptibility testing (DST) of Mycobacterium tuberculosis (Mtb) isolated from the sputum of the patient at the preoperative stage of treatment and from its surgical material. <b>Aim:</b> Analysis of the results of DST of Mtb isolated from surgical and respiratory m…
Puspa Acharya, N. K. Bhattarai, Bhuban Raj Kunwar, Khem R. Sharma, Vijay Kumar Khanal, et al.
Abstract Background Drug-resistant tuberculosis poses a significant threat to global TB control efforts, potentially reversing progress made in reducing TB-related morbidity and mortality. This study aims to identify risk factors for multidrug-resistant TB [MDR-TB] in Province 3,…
Harun Patel, Iqrar Ahmad, Harsha Jadhav, Rahul Pawara, Anand B. Mundada, et al.
…is the 9th leading cause of death worldwide above HIV/AIDS. Tuberculosis (TB) management remains challenging due to the emergence of drug-resistant tuberculosis such as MDR-TB and XDR-TB. To improvise therapeutic results for MDR/XDR-TB, 89 nations had started utilizing bedaquilin…
Preeti Sharma, Jinendra Singh Chauhan, Birjesh Singh
…dosing, incomplete treatment course, and the ability of the tuberculosis bacilli to tolerate and survive current first-line and second-line anti-TB drugs, in either their latent state or active state, has resulted in an increased prevalence of multidrug-resistant (MDR), extensive…
Assefa Hamato Kebede, Hassen Mamo Idris
Abstract Background : Tuberculosis (TB) is one of the oldest diseases known and the spread of drug-resistant TB poses significant challenges in TB control and eradication program globally, and also the distribution varies geographically worldwide and within the countries. Lack of…
Gaurav Sharma, Bharti Malhotra, P. J. John, Shipra Bhargava
…ain purpose of this study is the detection of Mycobacterium tuberculosis (MTB) and its drug resistance profile by molecular methods in pediatric patients suspected of pleural tuberculosis. Children ≤ 15 years of age suspected of pleuritis were enrolled in this study. Total 176 pl…
David Kajoba Mumena, Geoffrey Kwenda, Caroline Ngugi, Andrew Nyerere
Drug-resistant tuberculosis is a threat to the control of tuberculosis globally, it develops mainly due to mutations in target genes of (MTB). Mutations in the rpoB gene confer resistance to rifampicin (RIF). The most frequent mutations conferring resistance to RIF include; Ser53…
Pratik Kumar, Amardeepak Toppo, Roshan Lal, Sagarika Pradhan, Puneet Bhardwaj
…nd: There is an increasing incidence of multidrug-resistant tuberculosis (TB)/preextensively drug-resistant TB (XDR TB) and XDR TB globally. Therefore, rapid diagnostic tests with good sensitivity and specificity are need of hour. Truenat Mycobacterium tuberculosis (MTB) is one s…
Girija Shankar Udgata, Srikanta Dash -
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (MTB), one of the top 10 causes of death worldwide (ranking above HIV/AIDS). About a quarter of the world's population is infected with TB and thus at risk of developing TB disease. The Global TB Repo…
Parissa Farnia, Poopak Farnia, Jalaledin Ghanavi, Saeid Besharati, Ali Akbar Velayati
…model of latency in same clinical isolates of Mycobacterium tuberculosis (MTB). Methods: MTB strains were isolated from clinically and laboratory-confirmed cases of tuberculosis (TB). The TB isolates were subjected to the Xpert MTB/rifampin test and then, further susceptibility t…
World Health Organization. Regional Office for Europe
… to the burden of multidrug- and extensively drug-resistant tuberculosis (M/XDR-TB), all 53 Member States in the WHO European Region endorsed the Consolidated Action Plan to Prevent and Combat Multidrug- and Extensively Drug-resistant Tuberculosis in the WHO European Region 2011–…
World Health Organization. Regional Office for Europe
…est proportion of multidrug- and extensively drug-resistant tuberculosis (M/XDR-TB) patients in the world. The Consolidated Action Plan to Prevent and Combat Multidrug- and Extensively Drug-Resistant Tuberculosis in the WHO European Region, 2011–2015 was developed in 2011 and in …
Dr Hariharan
Background: Tuberculosis (TB) is a chronic infectious disease that has afflicted mankind for 5000 years. It has caused more deaths in adults than any other infectious disease The emergence of multidrug-resistant (MDR) TB has introduced challenging, but surmountable, complexities …
Thanaphon Yisankhun, Saran Sujinpram, Phimruethai Chongkratok, Sattawat Sanmai, Vatcharapong Sungketkit, et al.
… hospital was confirmed with pre-extensively drug-resistant tuberculosis (pre-XDR-TB) after a delay of over 30 days following an abnormal chest X-ray (CXR). We investigated to verify the outbreak and diagnosis, describe its characteristics, review the HCW TB screening program, an…
Xi-Ling Huang, Aliaksandr Skrahin, Pu-Xuan Lu, Sofia Alexandru, Valeriu Crudu, et al.
Abstract Multidrug-resistant tuberculosis (mdrtb) refers to TB infection resistant to at least two most powerful anti-TB drugs, isoniazid and rifampincin. It has been estimated that globally 3.5% (which can be much higher in some regions) of newly diagnosed TB patients, and 20.5%…
Dmytro Butov, Tetiana Butova, N. A. Rudova, Nadiya Sapelnik, Olena Borysova, et al.
… the treatment outcome of patients with multidrug-resistant tuberculosis (TB) and Beijing lineage 2 (BL2) of MTB. <b>Methods:</b> This is a prospective, cohort study of all patients with culture-confirmed pulmonary TB and MTB resistance to at least isoniazid and rifampicin. Bacte…
Supriya Dhakne
Introduction: Multidrug‑resistant tuberculosis (MDR‑TB) has created a significant health problem in most of the countries, and it is an obstacle to effective TB control. Aims and Objectives: The study aims to study the prevalence of MDR‑TB among new cases, retreatment cases and t…