Showing 26–50 of 52 documents
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Igor Mokrousov, Anna Vyazovaya, Neliya Vasilieva, Regina Mudarisova, Natalia Solovieva, et al.
…erm treatment. To gain molecular insight into Mycobacterium tuberculosis variation during long-term observation and treatment of chronic tuberculosis (TB) patients. The retrospective study enrolled nine tuberculosis patients who had multiple episodes of receiving anti-TB chemothe…
С. Н. Жданова, М. К. Винокурова, И. Г. Кондратов, Н. Е. Евдокимова, V. V. Sinkov, et al.
…he Republic of Sakha (Yakutia) since 2020, the incidence of tuberculosis (TB) has become lower than the Russian average against the background of an increase in the proportion of multidrug-resistant (MDR) strains of Mycobacterium tuberculosis, including among new cases. Objec tiv…
E. S. Ovsyankinа, Л. В. Панова, E. A. Krushinskaya, М. А. Багиров
…rt-curse chemotherapy regimens for treatment of MDR/pre-XDR tuberculosis in combination with surgery in older children and adolescents. Subjects and Methods. 51 patients with MDR/pre-XDR respiratory tuberculosis aged 13-17 years were enrolled in a prospective open study (2017-202…
Rizvan Abdullaev, A. M. Tikhonov, V. A. Shorokhova, О. Г. Комиссарова
…stry during chemotherapy of patients with MDR/XDR pulmonary tuberculosis receiving the short-course regimen containing bedaquiline, pretomanid, and linezolid (B-Pa-L). Subjects and Methods . 18 patients with MDR/pre-XDR/XDR pulmonary tuberculosis were enrolled into the study. The…
А. I. Gayda, A. V. Abramchenko, M. I. Romanova, T. V. Toichkina, V. S. Burykhin, et al.
…nts with multiple/pre-extensive drug resistant (MDR/preXDR) tuberculosis who interrupted treatment at different time points. Subjects and Methods. 800 patients with MDR/preXDR tuberculosis were enrolled in the study, they were from all regions of the Russian Federation and they s…
Soumya Renji, Rekha Solomon, Deepali Wankhade, Soonu Udani, Vrajesh Udani
…children admitted in our PICU with bacteriologically proven tuberculosis (smear, culture, poly-merase chain reaction, genotypic testing or Pyrosequencing) between January, 2007 and December, 2019 were retrieved. Drug resistance was classified as per World Health Organization defi…
ntroduction. Culture research and testing of Mycobacterium tuberculosis (MBT) for drug susceptibility in the Russian Federation is carried out with uneven qual-ity, which distorts the idea of primary drug resistance (DR). Aim. To study the primary DR of MBT to the main combinatio…
М.В. Ураксина, E. P. Еremenko, Е. А. Бородулина, B. Borodulin
The main problem in the treatment of tuberculosis (TB) patients is the increase in drug resistance of M.tuberculosis, which is not always detected at the start of chemotherapy, which leads to inadequate and lengthy treatment. Research objective . Analysis of the treatment of newl…
Tatiana Umpeleva, Kseniya Belousova, Ludmila Golubeva, Nataliya I. Eremeeva, Diana Vakhrusheva
…ackground:</b> The Beijing B0/W148 is a clone variant of M. tuberculosis (MTB) that is often detected in tuberculosis patients in Russia. It has stronger association with multidrug resistance and possesses unique pathogenic properties. <b>Objectives:</b> To identify the spectrum …
Y. I. Feshchenko, М. С. Опанасенко, О. V. Теreshkovych, S. М. Shalahai, О.И. Белогорцева, et al.
Tuberculosis (TB) in children is a complex of medical, biological and social problem of both international and national importance for many countries of the world and remains one of the main causes of death in the world. Surgical treatment can improve the results of treatment of …
Igor Mokrousov, V. V. Sinkov, П. А. Хромова, Alena Gerasimova, Ekaterina Chernyaeva, et al.
The <i>Mycobacterium tuberculosis</i> Mlva cluster 1071-32 belongs to the early ancient sublineage of the Beijing genotype. We have recently demonstrated its association with pre-XDR/XDR, increase in prevalence in parts of Russia (Northwest, Center, Siberia) and sporadic isolatio…
Fábio Rocha Formiga, Giovanna Gabriela Pedroza Rodrigues, Luanna de Ângelis Correia de Sousa, Douglas Dourado Oliveira, Ronaldo Nascimento de Oliveira, et al.
… of new bioactive compounds is a promising strategy against tuberculosis (TB), a disease caused mainly by Mycobacterium tuberculosis (Mtb). This approach becomes even more relevant given the increase in resistance to traditional drugs. Triazole derivatives emerge as relevant cand…
João Paulo de Lucena Laet, Lílian Maria Lapa Montenegro, Ana Lúcia Figueiredo Porto, Fábio Rocha Formiga, Ronaldo Nascimento de Oliveira, et al.
Tuberculosis (TB) is a chronic infectious disease that represents one of the greatest global public health challenges, especially in light of the increasing prevalence of resistant strains. Triazole-class molecules have been widely studied as promising candidates for new therapeu…
Yogesh Yadav, JYOTI CHOUDHARY, MOHAMMED NASIR KHAN
Objective: This study aimed to identify drug-resistant tuberculosis cases and treatment results. Because it is one of the few studies that have looked at the results of TB treatment among children in the nation, this one was noteworthy. Methods: Drug-resistant cases of paediatric…
R. V. Tarasov, E. V. Krаsnikovа, Л. Н. Лепеха, S. S. Sаdovnikovа, М. А. Багиров
…ment of the patient with disseminated destructive pulmonary tuberculosis with preXDR. The treatment included staged surgery using the original method of anterior mediastinum plasty with a mesh implant. The treatment resulted in the following outcomes: stabilization of the tubercu…
Beauty Makamure, Dan Ward, Tsitsi Bandason, Martha Chipinduro, Collins Timire, et al.
Background: Drug-resistant tuberculosis (DR-TB) is a major public health issue in Zimbabwe. Whole-genome-sequencing (WGS) is recommended for studying drug-resistant mutations, lineages, prevalence, and transmission patterns. However, there are limited data on drug-resistant confe…
…ound of anti-tuberculo-sis chemotherapy, a clinical cure of tuberculosis of the sole lung was achieved with the formation of metatu-berculous fibrotic focal changes without destruction. All patients were persistently abacillated. Conclusion. The proposed multi-stage therapeutic s…
Suneel Bhooshan, P. K. Khatri
…nd alcohol consumption was associated in 31.2% and 25.8% of tuberculosis cases. In our study mono resistance in isoniazid was 14.20% which was higher than mono rifampicin resistance of 9.20%. Our findings suggest high resistance to isoniazid alone is alarming as these strains may…
Akinduti Paul Akinniyi, Ajanaku Christiana Oluwatoyin, Oluwaseun Ejilude, Olumuyiwa Emmanuel Olukayode, Ofem Oluchi Gladys, et al.
… by the clonally diverse multi-drug resistant Mycobacterium tuberculosis complex (MDR-Mtbc) is alarming due to increasing resistance to available antimicrobials which further exacerbates the disease burden. The constituted chemical compounds (chemotypes) in Ocimum sanctum essenti…
Tatiana Minogina, Leonid Lavrenchuk, Diana Vakhrusheva, Sergey Skornyakov
…l complications and difficulties in detecting Mycobacterium tuberculosis (Mtb) in bone tissue. Molecular diagnostics have improved pathogen detection; however, cases with concomitant HIV andHCV infections remain problematic. These conditions, marked by immunosuppression, systemic…
Alexandra Isakova, Yu. D. Mikhailova, M. A. Sviridenko, Anastasia Khakhalina, Ksenia Galkina, et al.
… testing the drug susceptibility of clinical isolates of M. tuberculosis (MTB) to fluoroquinolones and injectable drugs using molecular genetic tests and phenotypic methods. We demonstrated the diagnostic capabilities of the hybridization technologies «TB-TEST and GenoType MTBDRs…
Arash Ghodousi, Alamdar Hussain Rizvi, Aiman Baloch, Abdul Ghafoor, Faisal Masood Khanzada, et al.
…s: Seventy three sequential isolates from 31 drug-resistant-tuberculosis patients on bedaquiline-containing regimens were retrospectively tested for bedaquiline resistance by MIC testing in 7H11 medium, and for all isolates showing an increased MIC compared to the baseline isolat…
Sahjid Mukhida, Chanda Vyawahare
Dear Editor, The global burden of tuberculosis (TB) is not hidden from everyone. Every year, national and international annual reports show the prevalence, disease burden, and mortality of TB nationally and Worldwide.[1] However, there is a lack of adequate knowledge and understa…
MEH Mohamed, MM Mukhtar, ME Hamad, AA Daffalla
… diagnosis, and management outcomes of Multi Drug Resistant-Tuberculosis (MDR-TB) in Sudan.This study aimed to assess MDR-TB diagnosis, management, treatment outcomes and predictors of treatment in Abu-Anga TB Reference Hospital in Sudan between the period 2015 -2021.A retrospect…
Natalya Eremeeva, Tatyana Umpeleva, Diana Vakhrusheva, Sergey Skornyakov, Leonid Lavrenchuk
The problem of resistance of <i>Mtb</i> to antibiotics is a global threat to humanity. Along with drug resistance, <i>Mtb</i> can also develop resistance to other biocides (e.g. disinfectants), but this phenomenon is currently not well understood and became the goal of this …