Showing 26–50 of 196 documents
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Kendra Brett, Camille Dulong, Melissa Severn
…eing pulmonary TB.,Individuals with TB are categorized into latent TB infection (LTBI) and active TB disease., LTBI refers to an individual who has the M. tuberculosis infection in which the bacteria are alive but are not currently causing active TB disease. Active TB disease occ…
Sana Sharrack, Caroline Zollinger-Read
…ent the case of a 75-year-old male with no risk factors for latent tuberculosis (TB), who was diagnosed with rheumatoid arthritis and appropriately escalated to adalimumab after failing two csDMARDs. His pre-biologic screen revealed a negative IGRA and normal chest X-Ray. He resp…
…on. Currently, there are no comprehensive clinical practice guidelines providing recommendations for the screening, diagnosis, treatment, and prevention of TB in RD patients. To address this issue, the Collaborative Group for TB Prevention and Control in Patients with RD in China…
Andrey S Borisov, MD, MPH, Robert Belknap, MD, Robert Belknap, MD
…al trial. The trial is conducted in patients diagnosed with latent tuberculosis infection (LTBI) who are recommended for treatment. The primary objective is to evaluate adherence to a three-month (12-dose) regimen of weekly rifapentine and isoniazid (3RPT/INH) given by directly o…
Delia Goletti, Seif Al-Abri, Giovanni Battista Migliori, Cecilia S. Lindestam Arlehamn, Pranabashis Haldar, et al.
… bacillus, Mycobacterium tuberculosis. Despite effective TB treatment being available for over 65 years, TB today causes 1.3 million deaths yearly, mostly in low- and middle-income countries. Drug-resistant TB is the leading cause of death owing to antimicrobial resistant disease…
Clare Bristow, Uli Schwab
…an Immunodeficiency Virus (HIV) are at an increased risk of latent Tuberculosis (TB) reactivation. HIV TB concurrent infection increases mortality and reduces patient quality of life. Screening for latent TB allows treatment to commence, preventing reactivation. In accordance wit…
Per Bjorkman, MD, PhD
…cts maternal and child health, can be used to construct new guidelines for management of TB in women of fertile age. This may contribute to reductions in adverse pregnancy outcomes, including maternal and infant deaths. Objective The overall objective of this project is to inves…
Nyanda E Ntinginya, MD, MSc., Ph.D, Nyasatu Chamba, MD., Irene Andia- Biraro, MD., Ph.D., Davis Kibirige, MD, Ph.D.
… expected to rise substantially as DM prevalence increases. Treatment of Latent TB Infection (LTBI) in this population will likely have a significant clinical benefit. Similar to HIV-infected individuals, those with DM might benefit from therapy to prevent the development of TB d…
Sema Aytac
…with the TB patients and determine whether or not they have latent TB infection and treat them and to detect the active cases among the contacts. In the current guidelines, the importance of screening all the contacts of the patients with pulmonary TB and applying a protective tr…
Eva Maria Guix-Comellas, Professor
…sis in children and young people receiving antituberculosis treatment (non-intervention group); and Phase 2: quasi-experimental, longitudinal, prospective study (intervention group). The results of the two phases will be compared. The study was carried out in the outpatient tube…
Tulane University
…kely TB) and in age-matched controls grouped by presence of latent TB infection (LTBI), with cfDNA measured serially in time among TB cases receiving antibiotic therapy. We will also validate standard ranges of quantitative cfDNA established for clinical subgroups of children wit…
Kendra Brett, Camille Dulong, Melissa Severn
…ion of TB bacteria.Individuals with TB are categorized into latent TB infection (LTBI) and active TB disease., LTBI refers to an individual who has the M. tuberculosis infection in which the bacteria are alive but are not currently causing active TB disease. Persons with LTBI do …
Richard E. Chaisson, MD, Susan Swindells, MBBS
… At the time the study was designed, the standard course of treatment for TB was 6 to 9 months of isoniazid (INH).This study compared the safety and effectiveness of a 4-week regimen of rifapentine (RPT) plus INH versus a standard 9-month regimen of INH in HIV-infected people who…
Christoph Lange, MD, PhD
…ct aims to improve the individual patient management and TB treatment outcomes, especially for patients with drug-resistant TB and/or co-morbidities. The study will be conducted in a co-operation between the Marius Nasta Institute, Division of Infectious Diseases \& Tropical Medi…
Sachin Atre
…o years after diagnosis of the index case.[3] TB preventive treatment (TPT) is recommended for all groups who may have the latent TB infection. These include children below and >5 years of age, adolescents, and adult household contacts. TPT remains a vital component of the active…
David Pride, Maria Gennaro, Michael Lauzardo, Niaz Banaei, Nahed Ismail, et al.
…tb) becomes ill. Therefore two TB-related conditions exist: latent TB infection (LTBI) and TB disease. People with latent TB infection are not ill and do not present TB symptoms or have TB disease. The only sign of TB infection is a positive reaction to the tuberculin skin test …
Karishma Saran, Tiziana Masini, Isaac Chikwanha, Gregory Paton, Rosalind Scourse, et al.
…e a subset of 23 key policies in diagnosis, models of care, treatment, prevention, and drug regulation to provide a snapshot of national TB policy adoption and implementation. We examine progress since an analogous 2015 survey of 23 of the same countries. Results At the time of t…
Francesca Montagnani, PhD, MD
…Australia) in the diagnosis of tuberculosis (TB - active or latent) in pediatric subjects (0 and 17 year)s recently exposed to infection (indicated as "contacts") or with clinical suspicion of active TB, and to compare the results obtained with those of the TuberculinSkin Test (T…
Zolelwa Sifumba
…d by mycobacteria that are resistant to standard first-line treatment, typically isoniazid and rifampicin (Seung et al., 2015). In 2023, MDR-TB caused an estimated 150,000 deaths globally, and over half of the global number of patients with MDR-TB were based in five countries: In…
David S.C. Hui, Chi Chiu Leung
…ion highlights the importance for developing more effective treatment modalities in order to reduce morbidity and mortality. In this contemporary concise review, articles related to these common respiratory infections and TB published recently in Respirology and selected articles…
Yamile Zabana Abdo, R de Francisco, Iago Rodríguez–Lago, María Chaparro, Fernando Gomollón, et al.
…n of a patient in the INFEII registry, (2) the incidence of latent TB; and (3) compliance with national and European recommendations. Methods A longitudinal prospective study of incident cases with IBD, initiated in October 2016 and with a planned follow-up of 5 years. In Septemb…
Cynthia Bin Eng Chee, David S.C. Hui
…bration, we present an opinion on advances in diagnosis and treatment of these common respiratory infections. Influenza and CAP continue to be important. The availability of pneumococcal vaccines and multiplex polymerase chain reactions (PCR) has led to a decreasing incidence of …
Luke Stickler, Emily N. Drwiega, Diane McKelvey, Tommy Windt, Scott Borgetti, et al.
…study investigated TB screening incidence, detection, & treatment (tx) practices of PWH in custody within the Illinois Department of Corrections (IDOC).Table 1:DemographicsTable 1 depicts subject demographics such as gender, age, HIV RNA and CD4 information, and risk factors …
Valentina Aksenova, Nadezda Klevno, Alexey Kazakov, А. Д. Пахлавонова
…to WHO, the effectiveness of currently available preventive treatment schemes for people of the risk groups is from 60 to 90%. However, up to date, preventive treatment guidelines have not been developed for people who have been in contact with patients with MDR-TB. Objective of …
Pranay Sinha, Karen R. Jacobson, C. Robert Horsburgh, Benjamin P. Linas, Carlos Acuña-Villaorduña
Abstract Background Treatment for latent tuberculosis infection (LTBI) with rifampin and isoniazid is very effective but carries significant hepatotoxicity risks, increasing with age. Further, since the risk of progression to tuberculosis (TB) disease declines with increasing tim…