Showing 26–50 of 81 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Trim Lajqi, Natascha Köstlin‐Gille, Christian Gille
… innate immune cells to exhibit rapid action with increased efficacy against subsequent infections. Here we will discuss the role of TRIM and its implications for infectious diseases in childhood. The Concept of Trained Innate Memory Although lacking an adaptive immune system, pl…
Professor Helen McShane, Professor Paul Moss
…linical challenge trial primarily to evaluate the safety of BCG challenge administered by the aerosol inhaled route in healthy, BCG naive UK adults. The trial will also look to evaluate and compare the amount of BCG recovered from the lungs and from the skin, following challenge …
Helen McShane, Gregory Hussey
This study is designed to evaluate the safety of the TB vaccine MVA85A in healthy children and infants in South Africa. A single vaccination with MVA85A has been shown to be safe and highly immunogenic in a wide range of subjects in previous clinical trials. In this trial,we will…
Wenping Gong, Ashok Aspatwar, Jianping Xie, Hao Li
…24, demands urgent innovation [1]. The limited and variable efficacy (0-80%) of the Bacille Calmette-Guérin (BCG) vaccine in adults, a challenge starkly highlighted during the COVID-19 pandemic, underscores the critical need for novel prophylactic and therapeutic strategies [2][3…
Julio HR Croda, PhD
…ncarceration (on average 3 years), primary prophylaxis with BCG revaccination may be a cost-effective alternative associated with mass screening for control of the disease. Recently, in a phase 2 clinical trial, the BCG vaccine was shown to be 45% effective in preventing sustaine…
M B Mouton, R M Horowitz, V M Limbert, L Bachnak, L A Morici, et al.
…ldwide. Intradermally administered Bacille Calmette-Guerin (BCG) is the only licensed Tb vaccine; however, BCG has limited efficacy in adults and vaccination site reactions. Additional issues include exclusion of immunocompromised/pregnant individuals, waning protection with age,…
Abiola Oduwole, JP Mwankon, Joseph Okebe, EB Esu, Moriam Chibuzor, et al.
Background: The Bacille Calmette-Guérin (BCG) vaccine, given as a single dose, offers variable protection against Tuberculosis (TB). It is plausible that repeat doses could improve the effectiveness of the BCG vaccine in settings where the population remain at risk of the disease…
Y. Su, Yin Cao, R L Wang, E J Dong, Weihong Zhao, et al.
Currently, Bacille Calmette-Guerin(BCG) is still the only admitted vaccine to prevent tuberculosis around the world. The target population is infants and children, but its protective efficacy is limited. As more and more studies have shown that re-vaccination with BCG protects ag…
Mohamed E. El Zowalaty, Hossam M. Ashour
…emely drug-resistant Mtb. In addition, the only approved TB vaccine is the current vaccine Bacille Calmette-Guérin (BCG), which provides partial and variable protection. Currently, there are at least 16 candidate vaccines in various stages of clinical development in the global TB…
Jorge Barrios‐Payán, Cristian Alfredo Segura-Cerda, Dulce Mata‐Espinosa, Helle Bielefeldt‐Ohmann, Rogélio Hernández‐Pando, et al.
…cination with Mycobacterium bovis Bacillus Calmette-Guerin (BCG) is effective in controlling severe forms of TB in childhood, with limited efficacy in preventing lung disease in adults, which is further reduced by infection with Beijing strains.We previously showed that a standar…
Mark Hatherill
…oject is to demonstrate safety, immunogenicity and improved efficacy of the new live attenuated M. tuberculosis vaccine called MTBVAC in a Phase 3 efficacy trial in HIV-uninfected infants born to HIV-infected and HIV-uninfected mothers as compared to standard of care BCG vaccinat…
Penny M. Heaton, Jeffrey S. Barrett
…scribes some of the institute's work on candidate drugs and vaccines against tuberculosis, the leading infectious diseases killer in the world. The Bill & Melinda Gates Medical Research Institute (Gates MRI) is a nonprofit biotechnology organization focused on diseases that dispr…
Ratih Pujilestari, Andriansjah Rukmana, Anis Karuniawati, M Usman, S Ismail, et al.
… Mycobacterium tuberculosis (Mtb). Bacille Calmette-Guérin (BCG) is the only licensed vaccine against TB, and it is effective in children but not in adults. The Vaccine Research Team, Department of Microbiology FKUI has developed a DNA-based TB vaccine candidate pcDNA3.1-rpfB. Th…
Xiaofang Zhao, Caihong Guo, Lianwen Wang, Zhijun Liu
…merge in the absence of systematic interventions. While the BCG vaccine provides substantial protection against infantile TB, its efficacy against pulmonary TB in adults varies significantly. Currently, six candidate vaccines aimed at preventing or delaying the progression from L…
Solomon Jauro, Erica C. Larson, Janelle L. Gleim, Brendon M. Wahlberg, Mark A. Rodgers, et al.
…in people living with HIV (PLWH). Bacillus Calmette-Guérin (BCG), the only approved TB vaccine, is effective in infants, but its efficacy in adolescents and adults is limited. Here, we investigated the immune responses elicited by BCG administered via intravenous (IV) or intrader…
S.H. Choi, Jiyun Park, Jung Joo Hong, Sung Jae Shin, Ju Mi Lee
The Bacillus Calmette-Guérin (BCG) vaccine, the only licensed vaccine against tuberculosis (TB), has played a crucial role in mitigating severe manifestations of the disease, particularly in children. However, its effectiveness against pulmonary TB in adults remains variable, lar…
GSK Clinical Trials
…s who are PPD-positive either via previous vaccination with BCG and/or conversion to PPD positivity through exposure to Mycobacterium tuberculosis. The BCG vaccine has been widely available for several decades. It is easy and cheap to produce, and when given to neonates or young…
Peter Kim, Soumya Swaminathan
…ew drugs in the clinical development pipeline, multiple new vaccine candidates, an array of new diagnostics and multiple clinical trials characterizing the efficacy and effectiveness of these new tools. For chemoprophylaxis and treatment, several new regimens have proven successf…
James M. Trauer, Andrew Kawai, Anna K. Coussens, Manjula Datta, Bridget M Williams, et al.
Abstract Background The variable efficacy observed in studies of BCG vaccination is incompletely explained by currently accepted hypotheses, such as latitudinal gradient in non-tuberculous mycobacteria exposure. We investigated heterogeneity in BCG vaccination in the context of p…
Dereck Tait, MD
…is clinical trial will evaluate safety, immunogenicity, and efficacy (prevention of Mtb infection as measured by IGRA conversions) of H56:IC31 in remotely BCG vaccinated adolescents. This clinical trial will evaluate safety, immunogenicity, and prevention of Mtb infection, (meas…
Zhuang Li, Yilu Zhao, Ling Yang, Linsheng Li, Zhaoyang Ye, et al.
…vent and control TB, the existing Bacillus Calmette–Guérin (BCG) vaccine exhibits limited protective efficacy in adult pulmonary TB. Therefore, developing a novel TB vaccine is an urgent need. This study designed a novel multi-epitope vaccine (MEV) to combat MTB infection, utiliz…
Beatrice Napoli
…days, it comprises the use of the Bacillus Calmette-Guérin (BCG) vaccine, developed one century ago but still the first-line weapon against TB. Despite evident challenges, that include variability in efficacy, vaccination with BCG has been proven to significantly reduce the incid…
Mark Hatherill, MD
… Infection with Mycobacterium tuberculosis of AERAS-404 and BCG Revaccination in Healthy Adolescents This Phase II, randomized, 3-arm, placebo controlled, partially blinded, clinical trial will be conducted in 990 healthy, HIV-uninfected, QFT-GIT negative, previously BCG vaccina…
Feng Shan, Andrew Simonson, Joshua D. Bromley, Michael C. Chao, Doaa Megahed, et al.
Abstract Description Background The limited efficacy of the BCG vaccine for adult pulmonary Tuberculosis (TB), as well as rising drug resistance, underscores the need for new vaccines and treatments. Concomitant immunity provides strong protection against M. tuberculosis (Mtb) re…
Korompis, Marcellus
…sease and drug resistance is greatest. The only licensed TB vaccine, Bacillus Calmette–Guérin (BCG), offers limited and inconsistent protection against adult pulmonary disease, necessitating the development of more effective vaccination strategies. This thesis explores subunit va…