Showing 1–25 of 49 documents
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Yassir Adam Shuaib
The Sudan is a high tuberculosis (TB) burden country (i.e. 77 per 100,000 population). Specifically, the eastern part of the country is endemic with high incidence rates of TB reaching up to 275 per 100,000 population during the past decade. Prevalence of Mycobacterium tuberculos…
Hanouf Niyazi
…ons of current and new drug regimens and the response of M. tuberculosis to treatment are complicated and time consuming. Other issues include the need for accurate and early detection, drug resistance screening and follow-up measures to ensure treatment completion as intended. T…
Nicholas Winters
La tuberculose est l'une des plus anciennes maladies infectieuses documentées et reste à ce jour un fardeau important pour la santé mondiale. On estime qu'un quart de la population mondiale vit avec une infection tuberculeuse et qu'environ 5 à 10 % d'entre eux développeront une t…
Nicholaus P. Mnyambwa
Tuberculosis remains one of the world’s deadliest infectious diseases in resource-limited settings, including Tanzania. Diagnostic challenges and minimal information on resistant tuberculosis complicate building effective management strategies. The current study employed whole ge…
Hlengiwe N. Mtetwa
… of infectious diseases. This is particularly important for tuberculosis (TB) and multidrug-resistant tuberculosis (MDR-TB), due to increasing globally infections and the associated economic burdens. TB and MDR-TB infections are high in several countries, with South Africa contri…
Dylan C. Farr
…gly important in solving several serious healthcare issues. Tuberculosis (TB) is among one of the world’s most serious health threats, especially in developing countries, and although treatment is available, current methods take 6 – 24 months. Prolonged treatment times often resu…
C Ashmi
BACKGROUND: Globally extra pulmonary tuberculosis (EPTB) accounts for 25% of all tuberculosis cases. The Gene Xpert MTB/RIF assay is a newly developed, automated diagnostic molecular test recommended by WHO for diagnosing EPTB. In the current situation determination of MDR status…
Peter M. Mbelele
Rifampicin or multidrug-resistant tuberculosis (RR/MDR-TB) accounts for considerable morbidity and mortality. Differences among Mycobacterium tuberculosis complex (MTBC) species may predict drug-resistance or treatment success. This thesis aimed at identifying MTBC at species lev…
Anita Svadzian
Tuberculosis (TB) is the second leading infectious disease killer worldwide after COVID-19; accounting for more than a quarter of the global TB burden, India shoulders the greatest TB burden in the world. High-quality care in TB includes early and accurate diagnosis, followed by …
Talent C. Dlamini
Background: The tuberculosis (TB) epidemic remains a major global health problem, noting that the Swaziland government had declared the disease a national emergency. Hence the study was aimed to determine the prevalence of TB in Swaziland and further to ascertain whether the circ…
Frederick Haraka
… early treatment are key in achieving global targets to end tuberculosis (TB). Between 2000 and 2017, nearly 54 million deaths were averted due to timely diagnosis and treatment initiation. Xpert MTB/RIF (“Xpert”¸Cepheid, Sunnyvale, CA, US) is a molecular diagnostic test with int…
Vallejo Janeta, Alexander Paolo
Mycobacterium tuberculosis is the principal causative agent of pulmonary tuberculosis. It constitutes a serious public health problem worldwide, especially in developing countries (e.g., Ecuador) where control strategies are scarce or inefficient. Some strains of this pathogen ha…
Laurent Nshizirungu, Denish Olet, Doreen Amulen, Michael Oming, Paul Luwuna, et al.
Background: Multidrug-resistant tuberculosis (MDR-TB) is a name given to tuberculosis agents when the bacteria are resistant to at least isoniazid and rifampicin, two of the most effective TB drugs. The study aimed to determine the prevalence and risk factors of MDR-TB among the …
Nonduduzo Magubane, Simangaliso Shangase
Introduction Multidrug-resistant tuberculosis (MDR-TB), which is TB resistant to critical anti-TB drugs such as isoniazid and rifampicin, presents a major challenge to tuberculosis treatment, leading to significant public health concerns. The study objective is to evaluate the pa…
Nadia Baartzes
Malaria and tuberculosis (TB) are infectious microbial diseases contributing to a major global health problem and remain a high priority.The problem is further compounded by the emergence of drug resistant strains of the respective causative agents. New therapies and drug design …
Mohau S. Makatsa
Tuberculosis (TB) remains the infectious disease causing the greatest global mortality, with an estimated 10 million incident cases of TB and 1.45 million deaths in 2018. Although there is a cure for TB, the success of the treatment is hampered by multidrug resistant TB and HIV i…
Ulanova (Igumnova), Viktorija
…e-size-fits-all approach to a more individualised strategy. Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (Mtb), which is transmitted between humans through the respiratory tract, most commonly affecting the lungs. TB is a major global public hea…
Ulanova (Igumnova), Viktorija
…e-size-fits-all approach to a more individualised strategy. Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (Mtb), which is transmitted between humans through the respiratory tract, most commonly affecting the lungs. TB is a major global public hea…
Winnie Nakiboneka
Background: Tuberculosis (TB) remains one of the world's leading causes of adult morbidity and mortality resulting in an estimated 8.8 million incident cases and 1.4 million deaths Up to 92% of the TB cases occur in low and middle-income countries with the sub-Saharan Africa regi…
Simon A. Larsson
Tuberculosis is one of the deadliest infectious diseases in the world. It is exacerbated by the rise of multi-drug resistant strains. Host-directed therapies are an innovative approach by targeting host pathways to enhance immunity and suppress bacterial replication. The work des…
Margaret W. M. Akinbileje
…s an exploration of a research study conducted on Pulmonary Tuberculosis (PTB) infection that has claimed many lives. The incidence of TB in Nigeria in 2016 was estimated to be 219 cases per 100,000 population, which accounts for about 4% of the TB incidence globally. Nigeria hol…
Le, Van Hong
Multidrug-resistant tuberculosis (MDR-TB) has been an emerging public health problem. MDR-TB is a fatal disease whilst treatment of MDR-TB is prolonged but less effective and toxic. Inter-individual variations in clinical presentation and treatment response have been reported in …
Wai Lai Chang
Tuberculosis (TB) remains the world’s second leading cause of death from a single infectious agent in 2022 after COVID-19[1]. The global number of people newly diagnosed with TB was over 10 million in 2022 [1]. There were an estimated 450 000 incident cases of MDR/RR-TB in 2021, …
Kumari Seema, Abhay Kumar, Manju Boipai, Ashok Sharma, Manoj Kumar
… area is mirrored by the functional state and efficiency of tuberculosis control programs running in the country. Material and Method: A total of 549 cases were recruited during the period from 2017 to 2019 and the data were analysed retrospectively. Both pulmonary and extra-pulm…
Ssv Jagadeeswara Rao Muvva
Tuberculosis infection remains a global health problem and the emergence of multidrugresistant TB (MDR-TB) adds further challenges in the battle to stop the spread of infection. Macrophages are the primary host cells to be infected with Mycobacterium tuberculosis (Mtb), and are t…